Adverse events following immunization of combined diphtheria, whole-cell pertussis, tetanus, and hepatitis B (DPwT/HB) vaccine

Main Article Content

Diana Mettadewi Jong
Alan R Tumbelaka
Abdul Latief

Abstract

Background Combined vaccine of diphtheria, whole-cell pertussis,
tetanus, and hepatitis B (DPwT/HB) will reduce the number of
injections to children and simplify the delivery logistics. The adverse
events following immunization (AEFI) of this vaccine have to be
concerned since the events may increase or decrease.
Objectives To evaluate AEFI of DPwT/HB vaccine in healthy in-
fants.
Methods A descriptive prospective study of AEFI of three doses
of DPwT/HB vaccine was performed on 74 healthy infants aged
two to six months at the Department of Child Health, Cipto
Mangunkusumo Hospital, from July 2000 to March 2001.
Results Out of 74 infants, 68 received two doses and 67 completed
the study with a total of 209 doses. Of 209 doses, adverse events
were reported following 126 doses (60.3%), consisted of systemic
(60.3%) and local reactions (9.5%). The three most frequent AEFI
iwere mild fever (44.5%), high fever (15.7%), irritability (31.5%).
Most AEFI were coincidental (51.1%), occurred after more than
72 hours (31.4%) and lasted less than 24 hours (17.7%). Sys-
temic reactions were mostly found in 4-month-old infants (33.3%),
while local reactions in 2-, 3-, and 5-month-old infants (25%),
respectively.
Conclusion Most AEFI were coincidental and resolved without
any complication

Article Details

How to Cite
1.
Jong D, Tumbelaka A, Latief A. Adverse events following immunization of combined diphtheria, whole-cell pertussis, tetanus, and hepatitis B (DPwT/HB) vaccine. PI [Internet]. 10Oct.2016 [cited 21Jul.2019];44(6):209-4. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/780
Section
Articles
Author Biographies

Diana Mettadewi Jong

Department of Child Health, Medical School University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Alan R Tumbelaka

Department of Child Health, Medical School University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Abdul Latief

Department of Child Health, Medical School University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Received 2016-10-03
Accepted 2016-10-03
Published 2016-10-10

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