Risk factors for mortality in children with Wilms tumor

  • Yuni Purwanti Department of Child Health, Gadjah Mada University Medical School/Dr. Sardjito Hospital Yogyakarta, Central Java
  • Sutaryo Sutaryo Department of Child Health, Gadjah Mada University Medical School/Dr. Sardjito Hospital Yogyakarta, Central Java
  • Sri Mulatsih Department of Child Health, Gadjah Mada University Medical School/Dr. Sardjito Hospital Yogyakarta, Central Java
  • Pungky Ardani Kusuma Department of Child Health, Gadjah Mada University Medical School/Dr. Sardjito Hospital Yogyakarta, Central Java
DOI: https://doi.org/10.14238/pi56.4.2016.226-9
Keywords: Wilms tumo, , risk factors for mortality, children

Abstract

Background Wilms tumor is the most common renal malignancy in children (95%) and one of the leading causes of death in children, with high mortality rates in developing countries. Identifying risk factors for mortality is important in order to provide early intervention to improve cure rates.


Objective To identify risk factors for mortality in children with Wilms tumor.


Methods We performed a case-control study of children (0-18 years of age) with Wilms tumor admitted to Dr. Sardjito Hospital between 2005 and 2012. The case group consisted of children who died of Wilms tumor, whereas the control group were children who survived. Data were collected from medical records. Statistical analyses using Chi-square and logistic regression tests were done to determine odds ratios and 95% CI of the potential risk factors for mortality from Wilms tumor.


Results Thirty-five children with Wilms tumor were admitted to Dr. Sardjito Hospital during the study period. Nine (26%) children died and 26 survived. Stage ≥III was a significant risk factor for mortality in chidren with Wilms tumor (OR 62.8; 95%CI 5.6 to 70.5). Age ≥2 years (OR 1.4; 95%CI 0.1 to 14.3) and male sex (OR 1.2; 95%CI 0.1 to 10.8) were not significant risk factors for mortality.


Conclusion Stage ≥III is a risk factor for mortality in children with Wilms tumor. 

References

1. Kellie SJ, Howard SC. Global child health priorities: what role for paediatric oncologists? Eur J Cancer. 2008;44:2388-96.
2. Ali K, Sutaryo S, Purwanto I, Mulatsih S, Supriyadi E, Widjajanto PH, et al. Yogyakarta Pediatric Cancer Registry: an international collaborative project of University Gadjah Mada, University of Saskatchewan, and the Saskatchewan Cancer Agency. Asian Pac J Cancer Prev. 2010;11:131-6.
3. Reinhard H, Furtwangler R, Graf N. Wilms tumor update. Urologe A. 2007;46:143-5.
4. Pastore G, Znaor A, Spreafico F, Graf N, Pritchard-Jones K, Steliarova-Foucher E. Malignant renal tumors incidence and survival in European children (1978-1997): report from the Automated Childhood Cancer Information System project. Eur J Cancer. 2006;42:2103-14.
5. Uba AF, Chirdan LB. Childhood Wilms tumor: prognostic factors in North Central Nigeria. West Afr J Med. 2007;26:222-5.
6. Abuidris DO, Elimam ME, Nugud FM, Elgaili EM, Ahmed ME, Arora RS. Wilms tumor in Sudan. Pediatr Blood Cancer. 2008;50:1135-7.
7. Pizzo PA, Poplack DG. Renal tumors. In: Fernandez C, Geller JI, Ehrlich PF, Hill DA, editors. Pediatric oncology. 6th ed. Philadelphia: Lippincott Williams and Wilkins; 2010. pp. 861-85.
8. Warmann SW, Furtwangler R, Blumenstock G, Armeanu S, Nourkami N, Leuschner I, et al. Tumor biology influences the prognosis of nephroblastoma patients with primary pulmonary metastases: results from SIOP 93-01/GPOH and SIOP 2001/GPOH. Ann Surg. 2011;254:155-62.
9. Narkbunnam N. Different approaches in management of Wilms tumor: pre or post operative chemotherapy. Siriraj Med J. 2009;61:274-89.
10. Ganesh S, Vennila JJ, Scholz H. An overview and perspectives of Wilms tumor. Int J Cancer Res. 2011;7:1-7.
11. Yang LL, Li MJ, Zheng ML, Xu S, Tang DX, Han YF. Prognostic factors and outcome of Wilms tumour in a tertiary children’s hospital, Cina. HK J Pediatr. 2009;14:108-14.
12. Corwin EJ. Kanker. In: Yudha EK, Wahyuningsih E, Yulianti D, Paryuni PE, editors. Patofisiologi. 3rd ed. Jakarta: Penerbit Buku Kedokteran EGC; 2009. p. 71-3.
13. Beniers AJ, Efferth T, Fuzesi L, Granzen B, Mertens R, Jakse G. p53 expression in Wilms tumor: a possible role as prognostic factor. Int J Oncol. 2001;18:133-9.
Published
2016-08-31
How to Cite
1.
Purwanti Y, Sutaryo S, Mulatsih S, Kusuma P. Risk factors for mortality in children with Wilms tumor. PI [Internet]. 31Aug.2016 [cited 22Nov.2024];56(4):226-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/770
Issue
Vol 56 No 4 (2016): July 2016
Section
Articles

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Received 2016-10-03
Accepted 2016-10-03
Published 2016-08-31