Comparison of absolute neutrophil count between premature and term infants
Keywords:
absolute neutrophil count, premature infant, term infant, neutropenia
Abstract
Background Neutrophils are very important in the body defenseagainst bacterial infection. Absolute neutrophil count (ANC) could
be used for the recognition of early-onset bacterial sepsis in
neonates.
Objective The aim of this study was to compare the value of ANC
between premature and term infants, to assess the prevalence of
early-onset neutropenia in premature infants and its relationship
with prematurity, and to find out the correlation between gesta-
tional age and ANC.
Methods A cross-sectional study was conducted during February
to May 2003. Subjects were newborn infants with gestational age
of less than 37 weeks who were born in Adam Malik and Pirngadi
Hospitals, Medan. Newborn infants with severe asphyxia (5-minute
Apgar score of less than 4), fever, seizure, and maternal
hypertension were excluded. Complete blood count was done by
means of automatic cell counter (Micros (R) , Germany). Term healthy
infants were used as control subjects.
Results ANC differed significantly between both groups (p=0.0001).
The prevalence of early-onset neutropenia in premature infants
was 9% (95%CI 0.065;0.21). Prematurity was related with the
incidence of neutropenia with a prevalence ratio of 1.1. There
was a weak positive correlation between gestational age and
ANC with an r-value of 0.49 (p=0.0001).
Conclusions ANC in premature infants differs from that in term
infants. The prevalence of early-onset neutropenia in premature
infants was 9% (95%CI 0.065;0.21). Prematurity is related with the
incidence of early-onset neutropenia in newborn infants. There is
a correlation between gestational age and ANC
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Late-onset neutropenia in very low birth weight infants.
Pediatrics 2000;106:1-7.
2. Engle WA, McGiure WA, Schreiner RL, Yu PL.
Neutrophil storage pool depletion in neonates with
sepsis and neutropenia. J Pediatr 1988;113:747-9.
3. Brazy JE, Grimm JK, Durham NC, Little VA. Neonatal
manifestations of severe maternal hypertension
occuring before the thirty-sixth week of pregnancy. J
Pediatr 1982;100:265-71.
4. Doron MW, Makhlouf RA, Katz VL, Lawson EE, Stiles
AD. Increased incidence of sepsis at birth in
neutropenic infants of mothers with preeclampsia. J
Pediatr 1994;125:452-8.
5. Madyono B, Moeslichan MZ, Sastroasmoro S, Budiman
I, Purwanto SH. Perkiraan besar sampel. In:
Sastroasmoro S, Ismael S, editors. Dasar-dasar
metodologi penelitian klinis. 1 st ed. Jakarta: Binarupa
Aksara; 1995. p. 187-212.
6. Manroe BL, Weinberg AG, Rosenfeld CR, Browne R.
The neonatal blood count in healthy and disease. Vol.
I. Reference values for neutrophilic cells. JOP
1979;95;89-98.
7. Mouzinho A, Rosenfeld CR, Sanchez PJ, Risser R. Revised
reference ranges for circulating neutrophils in very-low-birth-
weight neonates. Pediatrics 1994;94:76-82.
8. Xanthou M. Leucocyte blood picture in healthy full-
term and premature babies during neonatal period.
Arch Dis Child 1970;45:242-9.
9. Lakshman R, Finn A. Neutrophil disorders and their
management. J Clin Pathol 2001;54:7-19.
10. Gotoff SP. Infections of the neonatal infant. In:
Behrman RE, Kliegman RM, Jenson HB, editors.
Nelson textbook of pediatrics. 16 th ed. Philadelphia:
Saunders; 2000. p. 538-43.
11. Miller DR. Neutropenia. In: Miller DR, Behner RL,
Miller LP, editors. Blood diseases of infancy and child-
hood. 7 th ed. New York: Mosby; 1997. p. 562-76.
12. Stevens RF. Disorders of granulopoiesis and gronulocyte
function. In: Lilleyman JS, Hann IM, Blanchette VS,
editors. Pediatric hematology. 2 nd ed. London:
Churchill Livingstone; 2000. p. 331-8.
13. Behrman RE. Prematurity and intrauterine growth
retardation. In: Behrman RE, Kliegman RM, Jenson
HB, editors. Nelson textbook of pediatrics. 16 th ed. Phila-
delphia: Saunders; 2000. p. 477-85.
14. Levy O, Martin S, Eichenwald E, Ganz T, Valore E, Carroll SF,
et al. Impaired innate immunity in the newborn: newborn
neutrophil are deficient in bactericidal/permeability-increas-
ing protein. Pediatrics 1999;104:1327-33.
15. Gomella TL, Cunningham MD, Eyal FG, Zenk KE.
Neonatal sepsis. In: Gomella TL, Cunningham MD,
Eyal FG, Zenk KE, editors. Neonatology. 4 th ed.
Stamford: Appleton & Lange; 1999. p. 408-14.
Published
2016-10-10
How to Cite
1.
Faisal A, Tjipta G, Lubis B, Aldy D. Comparison of absolute neutrophil count between premature and term infants. PI [Internet]. 10Oct.2016 [cited 20Apr.2024];44(5):197-00. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/763
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Received 2016-10-02
Accepted 2016-10-02
Published 2016-10-10
Accepted 2016-10-02
Published 2016-10-10
