Adverse events following immunization (AEFI) reports of extended program immunization (EPI) in Indonesia during 1998-2002

Main Article Content

Nastiti Kaswandani
Sri Rezeki Hadinegoro
Rulina Suradi


Background The incidence of adverse events following immuni-
zation (AEFI) increased in correlation with the number of vaccine
doses. Meanwhile AEFI reports should be managed properly to
maintain the compliance and immunization coverage.
Objectives The aims of this study were to investigate the inci-
dence and profile of AEFI, its onset, severity, classification, and
Methods This study was a passive surveillance of AEFI reports
received by the National Committee on AEFI, Ministry of Health of
Indonesia, during 1998 to 2002.
Results Two hundreds and four AEFI cases were reported; 4 cases
as zero reports, 182 cases as individual reports, and 18 cluster
reports. The AEFI incidence was 0.44 per 1 million doses of vac-
cines. Vaccine reaction rate was 1 per 2.3 million vaccine doses.
The most common vaccines reported as the causes of AEFI were
DTP, Polio, and TT. Among 182 reported cases, local or mild AEFI
reactions were observed in 45, moderate in 49, and severe in 88.
Based on WHO field classification, this study reported that 84 cases
belonged to coincidence, 72 to vaccine reactions, 13 to program-
matic errors, 7 to injection reactions, and 6 to unclassified reac-
tions. Forty-seven patients died, 12 had some sequelae, and 123
completely recovered. Meanwhile, among the death cases, 70%
occurred coincidently, 17% due to vaccine reactions, and 6 were
Conclusions The incidence of AEFI in the extended program im-
munization (EPI) in Indonesia during the period of 1998-2002 were
182 cases, thus vaccine reaction rate was 1 per 2.3 million vac-
cine doses. The most common vaccine which caused AEFI was
DTP. Most AEFI with severe symptoms happened in 4-24 hours
after immunization.

Article Details

How to Cite
Kaswandani N, Hadinegoro S, Suradi R. Adverse events following immunization (AEFI) reports of extended program immunization (EPI) in Indonesia during 1998-2002. PI [Internet]. 10Oct.2016 [cited 21Jul.2019];44(4):153-. Available from:
Author Biographies

Nastiti Kaswandani

Department of Child Health, Medical School, University of Indonesia,
Cipto Mangunkusumo Hospital, Jakarta.

Sri Rezeki Hadinegoro

Department of Child Health, Medical School, University of Indonesia,
Cipto Mangunkusumo Hospital, Jakarta.

Rulina Suradi

Department of Child Health, Medical School, University of Indonesia,
Cipto Mangunkusumo Hospital, Jakarta.
Received 2016-09-30
Accepted 2016-09-30
Published 2016-10-10


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