Periventricular leucomalacia in premature infants in neonatal ward, Cipto Mangunkusumo Hospital: A preliminary study

  • Kemas Firman
  • Idham Amir
  • Nia Kurniati
  • Sudigdo Sastroasmoro
Keywords: premature infant, periventricular leucomalacia, prevalence, cranial ultrasound scan


Introduction Periventricular leucomalacia (PVL) is a major cause
of neurodevelopment delay in premature infants, so early detec-
tion of the preterm infant at high risk for the subsequent develop-
ment of this lesion is critical.
Objectives To determine the prevalence of PVL in premature in-
fants hospitalized in neonatal ward, Cipto Mangunkusumo Hospi-
tal using cranial ultrasound scans and define its characteristics
Methods Premature infants hospitalized in the neonatal ward from
January to July 2003 were included in this study. Clinical features
were retrieved from medical charts. Ultrasound scan was performed
once, after the age of 7 days and interpretations were read sepa-
rately by two consultants of the radiology division.
Results Fifty-one infants were included, 21 with <32-week gesta-
tion, 30 with >32-week gestation; birth weight range were 1000 to
2600 gram. Nineteen infants had cystic lesion and/or dilatation of
the ventricle from the cranial ultrasound scan. The prevalence of
PVL in gestational age (GA) of <32 weeks was 6/21 and that in GA
of >32 weeks was 13/30. Risk factors found in infants with PVL
were maternal infection, respiratory distress, sepsis and circula-
tory failure.
Conclusion The prevalence of PVL in preterm infants in Cipto
Mangunkusumo neonatal ward was higher than that was reported
in developed countries. Maternal infection, respiratory distress,
sepsis, and circulatory failure which were commonly found in these
infants were factors to be considered as risks for PVL

Author Biographies

Kemas Firman
Department of Child Health, Cipto Mangunkusumo Hospital,
Idham Amir
Department of Child Health, Cipto Mangunkusumo Hospital,
Nia Kurniati
Department of Child Health, Cipto Mangunkusumo Hospital,
Sudigdo Sastroasmoro
Department of Child Health, Cipto Mangunkusumo Hospital,


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How to Cite
Firman K, Amir I, Kurniati N, Sastroasmoro S. Periventricular leucomalacia in premature infants in neonatal ward, Cipto Mangunkusumo Hospital: A preliminary study. PI [Internet]. 10Oct.2016 [cited 12Aug.2022];44(3):122-. Available from:
Received 2016-09-30
Accepted 2016-09-30
Published 2016-10-10