Correlation between parasitemia and spleen size in patients with P. falciparum infection
Keywords:
parasitemia, splenomegaly, falciparum malaria
Abstract
Background Spleen is an important organ in immunity to malariainfection which is always affected in malaria patients. Enlargement
of the spleen is one of the main clinical symptoms of malaria. Level
of parasitemia is related to the risk of complications.
Objective To describe the correlation between parasitemia and
spleen size in patients with P.falciparum infection.
Methods One hundred and four patients including children and
adults with fever, pale, jaundice, diarrhea, and headache who vis-
ited public health centers in 5 villages in Mandailing Natal, North
Sumatera were enrolled in this study. The diagnosis of malaria
was based on blood smears stained by Giemsa method, while the
spleen size was measured using Hackett method. Correlation be-
tween parasitemia and spleen size was tested by Spearman rank
correlation.
Results Splenomegaly was found in 37 of 104 patients (35.6 %)
with the size of H1 in 10.6 %, H2 in 15.4 %, H3 in 9.6 %. The mean
parasite count between patients with and without splenomegaly
was different, and the difference was significant between patients
with spleen size of H0 and H3. The higher the parasitemia, the
bigger the spleen size was (r=0.291; p=0.03).
Conclusion There was a correlation between parasitemia and
spleen size in falciparum malarial infection
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PN, editor. Malaria: epidemiologi, patogenesis,
manifestasi klinis & penanganan. Jakarta: EGC;
1999. p. 151-64.
PN, editor. Malaria: epidemiologi, patogenesis,
manifestasi klinis & penanganan. Jakarta: EGC; 1999.
p. 166-83.
2. Rampengan TH, Laurentz IR. Penyakit infeksi tropis
pada anak. Jakarta: EGC; 1997. p. 185- 204.
3. Sri Purwaningsih. Diagnosis malaria. In: Harijanto
PN, editor. Malaria: epidemiologi, patogenesis,
manifestasi klinis & penanganan. Jakarta: EGC;
1999. p.185-93.
4. Bruce-Chwatt LJ. Essential Malariology. 2nd ed.
London: William Heinemann Medical Books Ltd;
1978. p. 72-8.
5. Langi J, Harijanto PN, Richie TL. Patogenesa malaria
berat. In: Harijanto PN, editor. Malaria: epidemiologi,
patogenesis, manifestasi klinis & penanganan. Jakarta:
EGC; 1999. p. 118-27.
6. Krogstad DJ. Plasmodium species (malaria). In:
Mandell GL, Bennet JE, Dolin R, editors. Principles
and practice of infectious diseases. New York: Churchill
Livingstone; 2000. p. 2817-30.
7. Nugroho A, Harijanto PN, Datau EA. Imunologi pada
malaria. In: Harijanto PN, editor. Malaria:
epidemiologi, patogenesis, manifestasi klinis &
penanganan. Jakarta: EGC; 1999. p. 129-49.
8. Sastroasmoro S. Dasar-dasar metodologi penelitian
klinis. Jakarta: Binarupa Aksara; 1995.
9. Rita Marleta, Harijani AM, Sustriayu N, Tjitra E. Penelitian
malaria di kecamatan Teluk Dalam Nias Sumatera Utara.
Cermin Dunia Kedokteran 1996;106:5-9.
10. Lubis NU. Gambaran penyakit malaria di bagian anak
Rumah Sakit Umum Langsa Aceh Timur. Cermin
Dunia Kedokteran 1994;94:14-5.
11. Albar H, Agustina IS, Hangewa P, Syamsiah I. Malaria
pada anak di RSU Ternate. Cermin Dunia Kedokteran
1994;96:28-30.
12. Rampengan T. Malaria. In: Soedarmo S, Garna H,
Hadinegoro S, editors. Buku ajar ilmu kesehatan anak
infeksi & penyakit tropis. 1 st ed. Jakarta: Balai Penerbit
FKUI; 2002. p. 442-71.
13. Jacobsen PH, Mckay V, N’jie R, Olaleye B,
D’Alessandro U, Zhang G, et al. Decreased antitoxic
activities among children with clinical episodes of
malaria. Infection and immunity 1998;66:1654-9.
14. Lubis CP. Sero epidemiologi malaria. Majalah
Kedokteran Nusantara 1990;3:135-46.
15. Annobil HS, Okeahialam TC, Jamjoom AG, Bassuni
WA. Malaria in children – experience from Asir region,
Saudi Arabia. Ann Saudi Med 1994;14:467-70.
16. Angulo I, Fresno M. Cytokines in the pathogenesis of
and protection against malaria. Clinical and diagnos-
tic laboratory immunology 2002;9:1145-52.
17. Genton B, Al-Yaman F, Alpers MP, Mokela D. Indica-
tors of fatal outcome in paediatric cerebral malaria: a
study of 134 comatose Papua New Guinean children.
Int J Epidemiol 1997;26:670-6.
18. Sutanto I, Pribadi W, Muljono R, Susanto L, Astuti H,
Rasidi R. Penelitian seroepidemiologi malaria di daerah
hipo dan mesoendemi Indonesia. In: Pribadi W,
Muljono R, Sutanto I, editors. Proceedings of Malaria
Symposium. Jakarta: FKUI; 1991. p. 25-36.
19. Taylor TE, Strickland GT. Infections of the blood
and reticuloendothelial system. In: Strickland GT,
editor. Hunter’s tropical medicine and emerging in-
fectious diseases. 8 th ed. Philadelphia: Saunders;
1999. p. 614-42.
20. Harijanto PN. Gejala klinik malaria. In: Harijanto
PN, editor. Malaria: epidemiologi, patogenesis,
manifestasi klinis & penanganan. Jakarta: EGC;
1999. p. 151-64.
Published
2016-10-10
How to Cite
1.
Lailani D, Lubis M, Lubis B, Pasaribu S. Correlation between parasitemia and spleen size in patients with P. falciparum infection. PI [Internet]. 10Oct.2016 [cited 24Apr.2024];44(3):111-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/747
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Received 2016-09-30
Accepted 2016-09-30
Published 2016-10-10
Accepted 2016-09-30
Published 2016-10-10
