Profile of alanine aminotransferase and hepatic iron accumulation in thalassemic patients with or without anti-hepatitis C virus

  • Purnamawati S P
  • Pamela Kartoyo
  • Imral Chair
  • Julfina Bisanto
  • Hanifah Oswari
Keywords: alanine aminotransferase, hepatic iron accumulation, transferrin saturation, anti hepatitis C virus, thalassemia

Abstract

Background Repeated blood transfusions in thalassemic patients
cause iron accumulation in tissues and might impair organ func-
tion. Other peril of blood transfusion is hepatitis C virus infection.
Objectives This study aimed to find out the proportion of increased
alanine aminotransferase (ALT), increased transferrin saturation
(TS), and positive anti hepatitis C virus (anti-HCV) among thalas-
semic patients and to get the profile of ALT among thalassemic
patients who have increased TS and positive anti-HCV.
Methods This cross-sectional descriptive study was conducted
on β- and β-HbE-thalassemic patients at the Thalassemia Outpa-
tient Clinic, Department of Child Health, Medical School, Univer-
sity of Indonesia–Cipto Mangunkusumo Hospital in May 2002.
Results Subjects were 57 homozygous β-thalassemic and 33 β-
HbE-thalassemic patients. No one had regular desferoxamine or
history of splenectomy. Proportions of increased ALT, TS, and posi-
tive anti-HCV were 76%, 78%, and 6%, respectively. Duration of
illness, total volume of packed red cell (PRC) transfusions, TS level,
and positive anti-HCV seemed to have role in the increased pro-
portion of subjects with increased ALT, whereas duration of illness
and total volume of PRC seemed to have role in the increased TS.
Conclusion Factors that seem to have a role in the increased
proportion of subjects who had increased ALT and TS were (1)
duration of illness, total volume of PRC transfusion, TS, and posi-
tive anti-HCV; 2) duration of illness and total volume of PRC trans-
fusion, respectively

Author Biographies

Purnamawati S P
Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta
Pamela Kartoyo
Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta
Imral Chair
Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta
Julfina Bisanto
Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta
Hanifah Oswari
Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta

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Published
2016-10-10
How to Cite
1.
P P, Kartoyo P, Chair I, Bisanto J, Oswari H. Profile of alanine aminotransferase and hepatic iron accumulation in thalassemic patients with or without anti-hepatitis C virus. PI [Internet]. 10Oct.2016 [cited 13Nov.2024];44(3):85-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/741
Section
Articles
Received 2016-09-29
Accepted 2016-09-29
Published 2016-10-10