Nephrologic abnormalities in neonatal asphyxia at Cipto Mangunkusumo Hospital, Jakarta
Keywords:
nephrologic abnormalities, neonatal asphyxia, oliguria, Apgar scores
Abstract
Introduction Neonatal asphyxia is still the leading cause of highmorbidity and mortality in developed countries, as well as in devel-
oping countries including Indonesia. As a response to asphyxia,
renal hypoxia occurs which is initially temporary, but if persisting,
can cause permanent damage to the cortex and medulla.
Objective The purpose of this study was to determine the
nephrologic abnormalities in neonatal asphyxia at Cipto
Mangunkusumo Hospital.
Methods This was a cross sectional descriptive study conducted
in the Division of Neonatology, Cipto Mangunkusumo Hospital from
August until November 2002. Neonates with congenital malforma-
tion were excluded.
Results The study showed that the incidence of nephrologic ab-
normalities in neonatal asphyxia based on Apgar scores at 1, 5,
and 10 minutes were 65/100, 26/33, and 5/6, respectively. The risk
of nephrologic abnormalities was not statistically different in se-
vere asphyxia compared to moderate asphyxia. Severe asphyxia
at 1 minute Apgar scores was correlated with the occurrence of
oliguria.
Conclusion In asphyxiated newborn, it is very important to inves-
tigate the possibility of nephrologic abnormalities
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berbagai organ tubuh akibat hipoksia dan iskemia
neonatus. In: Suradi R, Monintja HE, Amalia P,
Kusumowardhani D, editors. Penanganan mutakhir
bayi prematur: memenuhi kebutuhan bayi prematur
untuk menunjang peningkatan kualitas sumber daya
manusia. Naskah Lengkap Pendidikan Kedokteran
Berkelanjutan Ilmu Kesehatan Anak FKUI
XXXVIII. FKUI; 1997 April 7-8; Jakarta: Balai
Penerbit FKUI; 1997. p. 165-84.
2. Alisjahbana A, Hidayat S, Mintardaningsih, Primardi
A, Harliany E, Sofiatin Y, et al. Management of birth
asphyxia at home and health center. Paediatr Indones
1999;39:88-101.
3. Glucman PD, Tan W, Mallard C, Williamms CE. Patho-
physiology of perinatal asphyxia. In: Shankaran S, edi-
tor. Clinics in perinatology perinatal asphyxia. Phila-
delphia: Saunders; 1993. p. 305-26.
4. Indarso F. Dampak jangka panjang bayi asfiksia. Pro-
ceedings of the 11 th National Congress of Pediatrics;
1999 Jul 4-7; Jakarta, Indonesia. p. 547-57.
5. Dauber IM, Krauss AM, Symchych PS, Aula PAM. Re-
nal failure following perinatal anoxia. J Pediatr
1976;88:851-5.
6. Karlowicz MG, Adelman RA. Nonoliguric and oliguric
acute renal failure in asphyxiated term neonates.
Pediatr Nephrol 1995;9:718-22.
7. Snyder EY, Cloherty JP. Perinatal asphyxia. In: Cloherty
JP, Stark AR, editors. Manual of neonatal care. 4 th ed.
Philadelphia: Williams & Wilkins; 1998. p. 515-33.
8. Alatas H. Penilaian fungsi ginjal pada neonatus. In:
Marnoto W, Pusponegoro TS, Monintja HE, editors.
Masalah ginjal dan saluran kemih di bidang
perinatologi. Perinatologi tahun 2000. Jakarta: Balai
Penerbit FKUI; 1994. p. 7-14.
9. Carter BS, Nabb FM, Merenstein B. Prospective vali-
dation of a scoring system for predicting neonatal mor-
bidity after acute perinatal asphyxia. J Pediatr 1998;
132:619-23.
10. Mawardi H. Gangguan fungsi ginjal pada hipoksia neo-
natorum. MDK 1992;11:17-9.
11. Clark DA. Times of first void and first stool in 500
newborns. Pediatrics 1977; 60:457-9.
12. Kosnadi L. Nefrologi neonatal. In: Alatas H, Tambunan T,
Trihono PP, Pardede SO, editors. Buku ajar nefrologi anak.
2 nd ed. Jakarta: Balai Penerbit FKUI; 2002. p. 511-49.
13. Toth–Heyn P, Drukker A, Guignard JP. The stressed
neonatal kidney: from pathophysiology to clinical man-
agement of neonatal vasomotor nephropathy. Pediatr
Nephrol 2000;14:227-39.
14. Lubis EN. Pengaruh asfiksia neonatorum terhadap
fungsi ginjal [thesis]. Medan: Medical School, Univ of
Sumatera Utara; 2000.
15. Perlman JM, Tack ED, Martin T, Shackelford, Amon
E. Acute systemic organ injury in term infants after
asphyxia. Am J Dis Child 1989;143:617-20.
Published
2016-10-10
How to Cite
1.
Amir I, Manoe V, Tambunan T. Nephrologic abnormalities in neonatal asphyxia at Cipto Mangunkusumo Hospital, Jakarta. PI [Internet]. 10Oct.2016 [cited 22Nov.2024];44(2):66-2. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/739
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Received 2016-09-29
Accepted 2016-09-29
Published 2016-10-10
Accepted 2016-09-29
Published 2016-10-10
