Antibiotic profile in pediatric wards, Department of Child Health, Cipto Mangunkusumo Hospital
Keywords:
antibiotic, pediatric ward, hospitalized patients, single antibiotic, combined antibiotic
Abstract
Introduction The medical profession has currently come to a con-clusion that the major problem in the future is failure of treatment
due to antibiotic-resistant microorganisms.
Objective The aim of this study was to determine the profile of
antibiotics used in the Pediatric Wards of Department of Child Health,
Medical School, University of Indonesia, Cipto Mangunkusumo Hos-
pital, Jakarta.
Methods A descriptive retrospective study was conducted on all pa-
tients hospitalized in the Pediatric Wards of Department of Child Health,
Medical School, University of Indonesia, Cipto Mangunkusumo Hos-
pital during June–July 2001. Data were obtained from the medical
records of the patients.
Results Three hundreds and fifty-six hospitalized patients fulfilled
the inclusion criteria. The antibiotics were given to 48.7% of the
patients. The greatest user of antibiotics was the age group of 1-5
year-old, 50% of patients had been given single antibiotic and the
rest given combined antibiotics. The ICU used antibiotics most fre-
quently in contrast to the one-day care unit which used least. The
greatest use of single antibiotic was in the class 1-2 wards while
combined antibiotics were mostly used in the third class wards.
Single antibiotics used were cefotaxime (49.4%), amoxicillin
(20.7%), and ampicillin (11.55%). Combined antibiotics used were
ampicillin + chloramphenicol (34.5%), cotrimoxazole (21.8%),
cefotaxime + amikacin (5.7%), cefotaxime + cotrimoxazole (5.7%),
and cefotaxime + isoniazid + rifampicin + pyrazinamide (5.7%).
Conclusions The antibiotics most commonly used singly was
cefotaxime. The combination of antibiotic mostly used was ampi-
cillin + chloramphenicol
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Gaylord LM, editor. Clinical updates in pediatric infec-
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J, Modai J, et al. A non comparative multicenter
study of cefepime in the treatment of serious bac-
terial infections. J Antimicrobial Chemother
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12. Eggimen P. Cefepime monotherapy for the empiric
treatment of fever in granulocytopenia cancer patients.
J Antimicrobial Chemother 1993;32:151-63.
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serious bacterial infection. J Antimicrobial Chemother
1993;32:123-232.
14. Darmo Wardoyo. Demam tifoid. In: Sudarmo SSP,
Guna H, Hadinegoro SRS, editors. Infeksi dan penyakit
tropis. Buku ajar IKA FKUI RSCM. Jakarta: Balai
Penerbit FKUI; 2002. p. 367-75.
15. Suharso D, Hidayati SN. Infeksi susunan saraf pusat. In:
Soetomenggolo TS, Ismael, editors. Buku ajar neurologi
anak. Jakarta: Balai Penerbit IDAI; 1999. p. 339-81.
16. Leibovici L, Paul M, Poznanski O, Drucker M,
S a m r a Z , Ko n i g s b e r g e r H, P i t l i k S D.
Monotherapy versus betalactam aminoglycosides
combination treatment for Gram negative bac-
teria prospective observational study. J Antimi-
crobial Chemother 1997;41:1127-33.
17. Rahayoe N, Darmawan BS. Perkembangan mutakhir
penggunaan antibiotik untuk infeksi akut saluran nafas
pada anak. Proceedings of the Safari Ahli Respirologi
Anak; 2001 Sept 15-16; Jakarta, Indonesia. p. 45-50.
eration. In: Gilman AG, Limbral LE, Hordman JG,
editors. Goodman & Gilman’s the pharmacological
basis of therapeutics. 10 th ed. New York: McGraw-Hill;
2001. p. 1143-80.
2. Vossen JM. Proper use of antibiotics with particular
emphasis on their contribution to the emergence of
resistant bacteria. Presented at the Symposium on
Penanggulangan Penyakit Infeksi; 1990 Nov 25-29;
Jakarta, Indonesia.
3. Walson PD, Gefschman S, Koren G. Principles of drug
in infancy and children. Med Prog 1993;14:39-44.
4. Needlman RD. Growth and development. In:
Behrman, Kliegman, Arvin, editors. Nelson textbook
of pediatric. 16 th ed. Philadelphia: WB Saunders; 1998.
p. 30-3.
5. Latief A, Tumbelaka AR, Matondang CR, Chair I,
Bisanto S, Abdoerrachman MH, et al. Diagnosis band-
ing. In: Wahidiyat I, Sastroasmoro S, Matondang C,
editors. Diagnosis fisis pada anak. 2 nd ed. Jakarta:
Sagung Seto; 2000. p. 171-2.
6. Kovic SJN, Smith LG. Oral antibiotic therapeutics of
infectious diseases. In: Chunca BA, editor. Antibiotic
therapy part II. Med Clin North Am 2001;85:115-25.
7. Setiabudi R, Gan VHS. Antimikroba. In: Ganiswarna
SG, editor. Farmakologi dan terapi. 4 th ed. Jakarta: Gaya
Baru; 1995. p. 571-615.
8. Aronoff SC, Reed MD, Abrien L, Blumer JL. Compari-
son of the efficacy and safety of ceftriaxone to ampicil-
lin-chloramphenicol in the treatment of childhood men-
ingitis. J Antimicrobial Chemother 1984;13:143-51.
9. Klein JO. Antimicrobial agents. In: Feigin RP, Cherri
JD, editors. Infection disease of children. 3 th ed. Phila-
delphia: Saunders; 1992. p. 2179-98.
10. Correa AG. Update on cephalosporin in pediatric. In:
Gaylord LM, editor. Clinical updates in pediatric infec-
tious diseases IV. Philadelphia: Mosby; 2001. p. 1-8.
11. Mouton Y, Chidiac C, Humbert J, Leroy P, Veyssier
J, Modai J, et al. A non comparative multicenter
study of cefepime in the treatment of serious bac-
terial infections. J Antimicrobial Chemother
1993;32:54-64.
12. Eggimen P. Cefepime monotherapy for the empiric
treatment of fever in granulocytopenia cancer patients.
J Antimicrobial Chemother 1993;32:151-63.
13. Giamarella H. Low dosage cefepime as treatment for
serious bacterial infection. J Antimicrobial Chemother
1993;32:123-232.
14. Darmo Wardoyo. Demam tifoid. In: Sudarmo SSP,
Guna H, Hadinegoro SRS, editors. Infeksi dan penyakit
tropis. Buku ajar IKA FKUI RSCM. Jakarta: Balai
Penerbit FKUI; 2002. p. 367-75.
15. Suharso D, Hidayati SN. Infeksi susunan saraf pusat. In:
Soetomenggolo TS, Ismael, editors. Buku ajar neurologi
anak. Jakarta: Balai Penerbit IDAI; 1999. p. 339-81.
16. Leibovici L, Paul M, Poznanski O, Drucker M,
S a m r a Z , Ko n i g s b e r g e r H, P i t l i k S D.
Monotherapy versus betalactam aminoglycosides
combination treatment for Gram negative bac-
teria prospective observational study. J Antimi-
crobial Chemother 1997;41:1127-33.
17. Rahayoe N, Darmawan BS. Perkembangan mutakhir
penggunaan antibiotik untuk infeksi akut saluran nafas
pada anak. Proceedings of the Safari Ahli Respirologi
Anak; 2001 Sept 15-16; Jakarta, Indonesia. p. 45-50.
Published
2016-10-10
How to Cite
1.
Husni A, Abdoerrachman H, Akib A. Antibiotic profile in pediatric wards, Department of Child Health, Cipto Mangunkusumo Hospital. PI [Internet]. 10Oct.2016 [cited 19Apr.2024];44(2):46-0. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/734
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Received 2016-09-29
Accepted 2016-09-29
Published 2016-10-10
Accepted 2016-09-29
Published 2016-10-10
