The effectiveness of chloroquine compared to Fansidar in treating falciparum malaria
Keywords:
chloroquine, Fansidar, Plasmodium falciparum, drug resistance
Abstract
Background The most difficult problem in eradicating malaria isthe resistance of P. falciparum to drugs. Mandailing Natal has the
highest malaria incidence in North Sumatera.
Objective This study aimed to investigate the efficacy of chloro-
quine and Fansidar in treating falciparum malaria.
Methods A randomized double-blind study was done from April to
May 2001. Eighty-three patients with acute uncomplicated P.
falciparum malaria infection were randomized into two groups.
Group I (35 patients) received chloroquine and group II (48 pa-
tients) received Fansidar. Blood examinations were performed on
the 1 st , 2 nd , 7 th , and 28 th days.
Results The resistance of P. falciparum to drugs in the chloro-
quine group were found in 10 patients with R II and 1 patients with
R III, while in the Fansidar group, there were 14 patients with R II.
Conclusion The efficacy of chloroquine and Fansidar in treating
falciparum malaria was not significantly different
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R&D agenda. Geneva: Drugs for Neglected Diseases
Working Group; 2001 Sept.
2. Ministry of Health Republic of Indonesia. Profil
kesehatan Indonesia 2000. Jakarta: Departemen
Kesehatan RI; 2001. p. 37-46.
3. World Health Organization. Advances in malaria che-
motherapy. Report of a WHO Scientific Group. WHO
Technical Report Series 711. Geneva: The Institute;
1984. p. 7, 198-215.
4. World Health Organization. Drug resistance in malaria.
Report No: WHO/CDS/CSR/DRS/2001.4.
5. Tjitra E. Pengobatan malaria. Maj Kedok Indon
1996;46:24-32.
6. Pribadi W, Sungkar S. Malaria. Jakarta: Balai Penerbit
FKUI; 1994. p. 15-24.
7. Statistics of Sumatera Utara. Mandailing Natal dalam
angka. Medan: BPS Sumatera Utara; 2001.
8. Taylor TE, Strickland GT. Malaria. In: Strickland GT,
editor. Hunter’s tropical medicine and emerging infec-
tious diseases. Philadephia: W.B. Saunders Company;
2000. p. 614-43.
9. Ministry of Health Republic of Indonesia. Malaria: tes
resistensi untuk .falsiparum. Jakarta: Dit.Jen. PPM &
PLP; 1995.
10. Talogo RW. Statistik non-parametrik. In: Tjokronegoro
A, Sudarsono S, editors. Metodologi penelitian bidang
kedokteran. Jakarta: Balai Penerbit Fakultas Kedokteran
Universitas Indonesia; 1999. p. 155-66.
11. Panjaitan W, Simanjuntak J. Tes resistensi in vivo dan
in vitro mikro untuk .falsiparum terhadap beberapa jenis
obat di Sumatera Utara periode 1983-1986. Presented
at the Malaria Symposium, Medical School University
of Sumatera Utara; 1987 Aug 17; Medan, Indonesia.
12. Pribadi W, Dakung LS, Adjung SA. Infeksi plasmo-
dium falsiparum resisten terhadap klorokuin dari
beberapa daerah di Indonesia. Medika 1983;9:689-
93.
13. Tuti S, Arbani PR, Romzan A, Tjitra E, Rheny M.
Masalah P. falsiparum resisten terhadap klorokuin dan/
atau obat anti malaria lain di Kabupaten Banjar Negara
Jawa Tengah. Maj Kedok Indon 1994;6:377-83.
14. Mogi G, Rampengan TH. The effectiveness of sulphate
quinine compared to Fansidar in treating falciparum
malaria in children 6 months–7 years old. Paediat Indon
1991;31:104-10.
15. Ompusunggu S, Arbani PR, Marwoto HA, Tuti S,
Suwarni. Sensitivitas plasmodium falsiparum secara
in vitro terhadap beberapa macam obat di Sabang,
Aceh. Cermin Dunia Kedokteran 1989;54:19-21.
16. Malaria sudah resisten obat klorokuin. Harian
Republika 2002 Jan 18; p.19.
Published
2016-10-10
How to Cite
1.
Azlin E, Batubara I, Dalimunte W, Siregar C, Lubis B, Lubis M, Pasaribu S. The effectiveness of chloroquine compared to Fansidar in treating falciparum malaria. PI [Internet]. 10Oct.2016 [cited 23Dec.2024];44(1):17-0. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/727
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Received 2016-09-28
Accepted 2016-09-28
Published 2016-10-10
Accepted 2016-09-28
Published 2016-10-10
