Clinical and laboratory manifestations of childhood and adult-onset systemic lupus erythematosus in Cipto Mangunkusumo Hospital

Main Article Content

Syarif Faisal
Arwin Akib
Taralan Tambunan

Abstract

Background Childhood-onset SLE is more severe than the adult type.
Objective To compare the clinical and laboratory manifestations
of childhood- and adult-onset systemic lupus erythematosus (SLE).
Methods A retrospective study on child and adult SLE patients
was conducted in the Division of Pediatric Allergy and Immunol-
ogy, Department of Child Health and Department of Internal Medi-
cine, Medical School, University of Indonesia/CiptoMangunkusumo
Hospital (FKUI/RSCM) Jakarta.
Subjects One hundred and twenty-nine subjects met the study
criteria consisting on 54 childhood- onset (41.9%), 75 adult-onset
(58.1%), and 122 (94.6%) females and 7 (5.4%) males from Janu-
ary 1995 until December 2000.
Results Fever, arthralgia and vasculitis were the most frequent
signs found in both childhood-onset and adult-onset SLE. The liver,
spleen, lymph nodes, cardiovascular, gastrointestinal tract, and
eyes were the organs involved and significantly had a larger pro-
portion in the childhood-onset. Decrease of C3 was more frequently
found in the childhood-onset. Out of 17 childhood-onset patients
who died, 13 died at the age of 0-11 year-old. Two of the adult-
onset patients also died.
Conclusion Childhood-onset SLE had some different character-
istics compared to adult form

Article Details

How to Cite
1.
Faisal S, Akib A, Tambunan T. Clinical and laboratory manifestations of childhood and adult-onset systemic lupus erythematosus in Cipto Mangunkusumo Hospital. PI [Internet]. 10Oct.2016 [cited 21Jul.2019];43(6):199-04. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/692
Section
Articles
Author Biographies

Syarif Faisal

Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta.

Arwin Akib

Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta.

Taralan Tambunan

Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta.
Received 2016-09-24
Accepted 2016-09-24
Published 2016-10-10

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