Immunological basis of vaccination
Keywords:
Immunological basis, vaccination
Abstract
The basic mechanisms of body defencesagainst infectious diseases are both non-
specific and specific immune systems. Non-
specific immunity refers to mechanism of
protection that do not require specific recognition of
antigen, but that increase the protection afforded by
specific immune mechanisms. Non-specific immune
mechanisms include phagocytes, acute inflammatory
responses, type-1 interferon, and tumour necrosing
factor. Specific immunity consists of mechanisms of
protection that require specific recognition of antigen.
This immunity is highly specific, inducible,
discriminatory and unforgotten T lymphocyte-
dependent response. Normal specific immunity
operates under Major Histocompatibility Complex
restriction. It is the ability of this immune system to
refine its antigen recognition domains and establish
immunological memory that underlies the success of
active vaccination.
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RM, Jenson HB, editors. Nelson textbook of pediat-
rics. 16 th ed. Philadelphia: WB Saunders; 2000. p.
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Mc Graw-Hill Co; 1998.
3. Leitner WW, Ying H, Restifo NP. DNA and RNA-
based vaccines: principles, progress, and prospects.
Vaccine 1999;18:765-77.
4. Podda A. The adjuvanted influenza vaccines with novel
adjuvants: experience with the MF59-adjuvanted vac-
cine. Vaccine 2001;19:2673-80.
5. Singh M, O’Hagan D. Advances in vaccine adjuvants.
Nat Biotechnol 1999;17:1075-81.
6. Goldblatt D. Immunological principles of
vaccination.Vaccines: children & practice;3:44-5.
7. Romagnani S. The T-Cell subsets (Th-1 versus Th-2).
Ann Allergy Asthma Immunol 2000;85:9-18.
8. Gray D. Immunological memory. Annu Rev Immunol
1993;11:49-77.
9. Sallusto F, Lanzavecchia A. Exploring pathways for
memory cell generation. J Clin Invest 2001;108:805-6.
10. Sprent J, Surh CD. Generation and maintenace of memory
T cells. Curr Opinion Immunol 2001;13:248-54.
11. Goldsby RA, Kindt TJ, Osborne BA. Vaccines. Kuby im-
munology. 4 th Ed. New York:.WH Freeman and Co; 2000.
p. 449-65.
12. Rupert SJR, Chan CJ, Kuter BJ, Kaplan KM, Waters M,
Kutzler DP, et al. Childhood vaccination against variclla:
persistence of antibody, duration of protection and vac-
cine efficacy. J Ped 2001;139:297-304.
13. Weiner DB, Kennedy RC. Genetic vaccines. Sci Am
1999;281:50-7
14. De-Serres G, Shadmani R, Boulianne N, Duval B,
Rochette L, Douvil-Fradet L, et al. Effectiveness of a single
dose of cellular pertussis vaccine to prevent pertussis in
children primed with pertussis whole cell vaccine. Vac-
cine 2001;19:3004-8.
15. Guranathan S, Klinman DM, Seder RA. DNA vaccines:
Immunology, application and optimisation. Annu Rev
Immunol 2000;18:927-74.
16. Donelly JJ, Ulner JB, Shiver JW, Liu MA. DNA vaccines.
Annu Rev Immunol 1997;15:617-48.
Published
2016-09-26
How to Cite
1.
Harsono A. Immunological basis of vaccination. PI [Internet]. 26Sep.2016 [cited 25Apr.2024];43(5):151-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/684
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Received 2016-09-24
Accepted 2016-09-24
Published 2016-09-26
Accepted 2016-09-24
Published 2016-09-26
