Comparison of seroconversion rates between low-dose intradermal and recommended dose intramuscular hepatitis B vaccination in children
Keywords:
Hepatitis B vaccination, intradermal, intramuscular, seroconversion
Abstract
Introduction Massive hepatitis B vaccination is expensive. Re-sults of studies showed that reduced dosage given intradermally
to adults and intramuscularly to children were able to induce
seroconversion.
Objective To compare the anti-HBs seroconversion (seropositive
and seroprotective) rates between intradermal low-dose of 2 mg
(ID-2) and intramuscular recommended dose of 10 mg (IM-10)
vaccination against hepatitis B.
Methods In a randomized clinical trial, using the hepatitis B plasma
vaccine, elementary school children in Tanjung Enim subdistrict,
80-168 months of age, were randomly assigned to be given three
doses of either the ID-2 (n=59) or IM-10 (n=64) vaccinations at
one month intervals. Seropositive (anti HBs titer >2.1 mIU/l) and
seroprotective (anti HBs >10 mIU/l) rates as well as the seroposi-
tive and seroprotective geometric mean antibody titers (GMTs) were
compared one month after each inoculation. A p value of <0.1
was considered statistically significant.
Results One month after the third inoculation, there was no sig-
nificant difference in the seropositive rate (95% vs. 89%),
seroprotective rate (85% vs. 83%), seropositive GMTs (55.85 mIU/
l vs. 61.24mIU/l), and seroprotective GMTs (73.86 mIU/l vs. 72.49
mIU/l) between the ID-2 and the IM-10 groups (all with p>0.1)
Conclusion Reduced doses of the hepatitis B vaccine given in-
tradermally may offer protection against hepatitis B, thus it may be
useful for mass vaccination programs
References
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DP. Intradermal HBV vaccination: immunogenicity and
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titis B for accelerated prophyalxis. Pediatr Infect Dis
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cination: five years’ experience of primary vaccination.
Med J Austr 1993;158:372-8.
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Serovich J. Intradermal hepatitis B vaccination in a large
hospital employee population. Vaccine 1991;7:58-62.
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CH, Huntley AC, et al. Intradermal inoculation with
Heptavax B: immune response and histologic evalua-
tion of injection sites. JAMA 1989;262:2567-71.
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mance holds promise of cost savings. Hevac Bulletin
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dan pencegahan hepatitis B. 1 st ed. Jakarta: Yayasan
Penerbitan Ikatan Dokter Indonesia; 1998.
2. Hidayat B. Pemberian vaksin hepatitis B pada anak secara
universal. Proceedings of the Symposium on up date of
hepatitis B prevention in children; 1993 Aug; p.1-6.
3. Sulaiman A, Julitasari. Virus hepatitis A sampai E di
Indonesia. Jakarta: Yayasan Penerbit Ikatan Dokter
Indonesia; 1995.p.16-76.
4. Direktorat Jenderal PPM dan PLP Depkes RI. 2 nd ed.
Petunjuk teknis pelaksanaan imunisasi hepatitis B.
Jakarta: Departemen Kesehatan; 1996. p.1-20.
5. Redfield RR, Innis BL, Scott RM, Cannon HG,
Bancroft WH. Clinical evaluation of low-dose intrad-
ermally administered hepatitis B virus vaccine: a cost-
reduction strategy. JAMA 1985;254:3203-6.
6. Bryan JP, Sjogren MH, Perine PL, Legters LJ. Review
articles: low dose intramuscular vaccination against
hepatitis B. Clin Infect Dis 1992; 14: 697-707.
7. Wahl M, Hermodsson S. Intradermal, subcutaneous
or intramuscular administration of hepatitis B vaccine:
side effects, antibody response. Scand J Infect Dis
1987;19:617-21
8. Miller KD, Mulligan MW, Gibbs RD, Hutman TS, Francis
DP. Intradermal HBV vaccination: immunogenicity and
side effects in adults. Lancet 1983;2:1454-56.
9. Bryan JP, Sjogren M, Igbal M, Khattak AR, Nabi S,
Ahmed A, et al. Comparative trial of low-dose, intrad-
ermal recombinant and plasma derived hepatitis B vac-
cines. J Inf Dis 1990;162:789-793.
10. Leonardi S, Musumeci S, Sciacca A, Greco D, Romano
C. Reliability of intradermal vaccination against hepa-
titis B for accelerated prophyalxis. Pediatr Infect Dis
1990;336:520.
11. Thomson SC, Darlington R, Tallent DB, Forsyth JRL.
Effectiveness of low dose intradermal hepatitis B vac-
cination: five years’ experience of primary vaccination.
Med J Austr 1993;158:372-8.
12. Coleman PJ, Shaw FE, Hadler SC, Margolis HS,
Serovich J. Intradermal hepatitis B vaccination in a large
hospital employee population. Vaccine 1991;7:58-62.
13. Clark JA, Hollinger FB, Lewis E, Russell LA, Miller
CH, Huntley AC, et al. Intradermal inoculation with
Heptavax B: immune response and histologic evalua-
tion of injection sites. JAMA 1989;262:2567-71.
14. NN. Low-dose vaccine in children: impressive perfor-
mance holds promise of cost savings. Hevac Bulletin
1995;3:1-3
Published
2016-09-24
How to Cite
1.
Harsono S, Anwar Z, Pardede N. Comparison of seroconversion rates between low-dose intradermal and recommended dose intramuscular hepatitis B vaccination in children. PI [Internet]. 24Sep.2016 [cited 8Nov.2024];43(4):140-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/678
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Received 2016-09-23
Accepted 2016-09-23
Published 2016-09-24
Accepted 2016-09-23
Published 2016-09-24
