Inhibiting ability of benzathine penicillin G towards group A Streptococcus β -hemolyticus in 21 and 28 days after a single intramuscular injection

  • Bambang Madiyono
  • Mulyadi M Djer
  • Sudigdo Sastroasmoro
  • Amin Subandrio
  • Erni Erfan
Keywords: Acute rheumatic fever, benzathine penicillin, serum inhibitory concentration, serum bactericidal concentration

Abstract

Background The effectiveness of a single intramuscular
benzathine penicillin G as a secondary prevention of acute rheu-
matic fever after 28 days is still controversial. The latest study
showed that serum penicillin concentration was below protective
level in 4 weeks after a single intramuscular injection.
Objective This study was a preliminary study to compare the in-
hibiting ability of benzathine penicillin G towards group A Strepto-
coccus β -hemolyticus in 21 and 28 days after a single IM injection
by using Mueller-Hinton broth method.
Methods The inhibiting ability was measured by the serum in-
hibitory concentration and serum bactericidal concentration after
a single intramuscular injection of benzathine penicillin G 1.2 mil-
lion units.
Results The subjects were 28 patients, with mean age of 15.5
years (SD 3.4). The numbers of male and female were equal. Mean
serum inhibitory concentration in 21 days after a single injection
was 926.4 (SD 3080.1) and after 28 days was 1540.9 (SD 4275.1),
which was not significantly different (p=0.0662). Mean serum bac-
tericidal concentration in 21 days after IM injection was 1579.6
(SD 4265.7) and in 28 days was 2417 (SD 6849.4) and it was not
statistically different (p=0.2276).
Conclusion This study concluded that there was no significant
difference in the inhibiting ability of benzathine penicillin G to-
wards group A Streptococcus β -hemolyticus between 21 and 28
days after a single intramuscular injection

Author Biographies

Bambang Madiyono
Department of Child Health, Division of Cardiology, Medical School, University of Indonesia, Cipto Mangunkusumo Hospital
Mulyadi M Djer
Department of Child Health, Division of Cardiology, Medical School, University of Indonesia, Cipto Mangunkusumo Hospital
Sudigdo Sastroasmoro
Department of Child Health, Division of Cardiology, Medical School, University of Indonesia, Cipto Mangunkusumo Hospital
Amin Subandrio
Department of Child Health, Department of Microbiology, Medical School, University of Indonesia, Cipto Mangunkusumo Hospital
Erni Erfan
Biomedical Science
Post Graduate UI Student

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Published
2016-09-24
How to Cite
1.
Madiyono B, Djer M, Sastroasmoro S, Subandrio A, Erfan E. Inhibiting ability of benzathine penicillin G towards group A Streptococcus β -hemolyticus in 21 and 28 days after a single intramuscular injection. PI [Internet]. 24Sep.2016 [cited 22Nov.2024];43(4):136-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/677
Section
Articles
Received 2016-09-23
Accepted 2016-09-23
Published 2016-09-24