Inhibiting ability of benzathine penicillin G towards group A Streptococcus β -hemolyticus in 21 and 28 days after a single intramuscular injection
Keywords:
Acute rheumatic fever, benzathine penicillin, serum inhibitory concentration, serum bactericidal concentration
Abstract
Background The effectiveness of a single intramuscularbenzathine penicillin G as a secondary prevention of acute rheu-
matic fever after 28 days is still controversial. The latest study
showed that serum penicillin concentration was below protective
level in 4 weeks after a single intramuscular injection.
Objective This study was a preliminary study to compare the in-
hibiting ability of benzathine penicillin G towards group A Strepto-
coccus β -hemolyticus in 21 and 28 days after a single IM injection
by using Mueller-Hinton broth method.
Methods The inhibiting ability was measured by the serum in-
hibitory concentration and serum bactericidal concentration after
a single intramuscular injection of benzathine penicillin G 1.2 mil-
lion units.
Results The subjects were 28 patients, with mean age of 15.5
years (SD 3.4). The numbers of male and female were equal. Mean
serum inhibitory concentration in 21 days after a single injection
was 926.4 (SD 3080.1) and after 28 days was 1540.9 (SD 4275.1),
which was not significantly different (p=0.0662). Mean serum bac-
tericidal concentration in 21 days after IM injection was 1579.6
(SD 4265.7) and in 28 days was 2417 (SD 6849.4) and it was not
statistically different (p=0.2276).
Conclusion This study concluded that there was no significant
difference in the inhibiting ability of benzathine penicillin G to-
wards group A Streptococcus β -hemolyticus between 21 and 28
days after a single intramuscular injection
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2. Madiyono B. Tata laksana masalah kardiologi anak.
Sari Pediatri 1994;1:147-54.
3. Wahab AS. Demam reumatik akut. In: Sastroasmoro
S, Madiyono B, editors. Buku ajar kardiologi anak.
Jakarta: Binarupa Aksara; 1994. p. 279-316.
4. Stollerman GH, Irvington P, Rusoff JH. Prophylaxis
against group A streptococcus infection in rheumatic
fever patients. JAMA 1952;150:1571-5.
5. Ginsburg CM, McCracken GH, Zweighaft TC. Serum
penicillin concentration after intramuscular adminis-
tration of benzathine penicillin G in children. Pediat-
rics 1982;69: 452-4.
6. Lue HC, Wu MH, Hsieh KH. Rheumatic fever recurrences:
controlled study of 3-week versus 4-week benzathine peni-
cillin prevention program. J Pediatr 1986;108:299-304.
7. Padmavati S. Rheumatic fever and rheumatic heart dis-
ease in developing countries. Bulletin of the WHO
1978;56:543-50.
8. Kaplan EL, Berrios X, Speth J, Siefferman T, Guzman
B, Quesny F. Pharmacokinetics of benzathine penicil-
lin G: serum levels during the 28 days after intramus-
cular injection of 1.200.000 units. J Pediatr
1989;115:146-50.
9. Lorian V. Antibiotics in laboratory medicine. 2 nd ed.
Baltimore: William & Wilkins; 1986. p. 466-7.
10. WHO expert committee. Prevention of rheumatic fe-
ver, WHO Technical Report Series No. 342. Geneva:
World Health Organization; 1966.
Published
2016-09-24
How to Cite
1.
Madiyono B, Djer M, Sastroasmoro S, Subandrio A, Erfan E. Inhibiting ability of benzathine penicillin G towards group A Streptococcus β -hemolyticus in 21 and 28 days after a single intramuscular injection. PI [Internet]. 24Sep.2016 [cited 1May2024];43(4):136-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/677
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Received 2016-09-23
Accepted 2016-09-23
Published 2016-09-24
Accepted 2016-09-23
Published 2016-09-24
