The prevalence of hyaline membrane disease and the value of shake test and lamellar body concentration in preterm infants
Keywords:
shake test, lamellar body, HMD, preterm infant
Abstract
Background The morbidity and mortality of hyaline membrane dis-ease (HMD) are quite high due to delayed diagnosis and intervention.
Commonly, HMD occurs in preterm infants with surfactant deficiency
because of lung immaturity. Lung maturity test could be performed
using biochemical, biophysical, and amniotic fluid turbidity test.
Objective To find out HMD prevalence and the value of shake
test and lamellar body concentration in diagnosing HMD in preterm
infants.
Methods This was a cross-sectional study carried out at Hasan
Sadikin Hospital Bandung on preterm infants born during October-
December 2001. The shake test was performed using gastric fluid
and amniotic fluid while the lamellar body concentration was per-
formed using amniotic fluid.
Results During the 3-month period, 571 infants were born, of 64
(11.2%) preterm infants, only 41 (64%) fulfilled the inclusion crite-
ria; among those preterm infants, 14 (34%) suffered from respira-
tory distress and 7 suffered from HMD (prevalence 17%). All HMD
cases occurred in infants less than 32 weeks for gestational age.
In 7 preterm infants with HMD, the shake test of gastric fluid ob-
tained by lavage showed negative results in 3 and +1 in 4 infants;
while the shake test of amniotic fluid revealed negative result in 5
and +1 in 2 infants. Lamellar body concentration of amniotic fluid
was ≤18,000/ml in all HMD infants. Among three infants less than
32 weeks for gestational age who did not suffer from HMD, +1
shake test of gastric fluid was found in 2 infants and +2 in 1 infant;
while shake test of amniotic fluid showed negative result in 1 infant
and +1 in 2; the lamellar body concentration of amniotic fluid was
≤18,000/ml in 2 infants and >18,000/ml in 1 infant.
Conclusions We concluded that HMD occurred in 17% of preterm
infants. The shake test of gastric and amniotic fluids revealed nega-
tive or +1 results whereas lamellar body concentration had value
of less than or equal to 18,000/mL. More extensive studies are
warranted to assess the validity (sensitivity, specificity and predic-
tive values) of these measurements
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newborn: hyaline membrane disease. In: Cunningham
FG, MacDonald PC, Gant NF, Leveno KJ, Gilstrap LC,
Hankins GDV, et al, editors. Williams Obstetrics. 20 th
ed. London: Appleton & Lange; 1997. p. 967-71.
3. Smallwood R. Clinical Practice guidelines: care around
preterm birth. Australia: NHMRC; 2000. p. 12-8.
4. Walker M, Hull A. Preterm labor and birth. In:
Taeusch HW, Ballard RA, editors. Avery‘s diseases of
the newborn. 7 th ed. Philadelphia: WB Saunders;
1998. p. 144-51.
5. Hansen T, Corbet A. Disorders of the transition: hya-
line membrane disease. In: Taeusch HW, Ballard RA,
editors. Avery‘s diseases of the newborn. 7 th ed. Phila-
delphia: WB Saunders; 1998. p. 602-13.
6. Bancalari E, Bidegain M. Respiratory disorders of the
newborn: hyaline membrane disease. In: Taussig LM,
Landau LI, Le Souef PN, Morgan WJ, Martinez FD,
Sly PD, editors. Pediatric respiratory medicine. St.
Louis: A Times Mirror; 1999. p. 464-71.
7. Gross I. Respiratory system: developmental consider-
ation, respiratory distress syndrome. In: Mc Millan JA,
DeAngelis CD, Feigin RD, Warshaw JB, editors. Oski‘s
pediatrics principles and practice. 3 th ed. Philadelphia:
Lippincott Williams & Wilkins; 1999. p. 250-8.
8. Stoll BJ, Kliegman RM. The fetus and the neona-
tal infant. In: Behrman RE, Kliegman RM, Jenson
HB, editors. Nelson textbook of pediatrics. 16 th ed.
Philadelphia: WB Saunders; 2000. p. 451-3, 477-
85, 496-505.
9. Field NT, Gilbert WM. Current status of amniotic fluid
test of fetal maturity. In: Pitkin RM, Scott JR, editors.
Clinical obstetrics and gynecology. Lippincot: Raven
publishers; 1997. p. 366-86.
Published
2016-10-10
How to Cite
1.
DLH D, Usman A, Nataprawira M, Primadi A. The prevalence of hyaline membrane disease and the value of shake test and lamellar body concentration in preterm infants. PI [Internet]. 10Oct.2016 [cited 25Nov.2024];43(3):77-1. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/665
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Received 2016-09-23
Accepted 2016-09-23
Published 2016-10-10
Accepted 2016-09-23
Published 2016-10-10
