Neurological impairment of children with history of prematurity and neonatal hyperbilirubinemia

  • Ida Bagus Subanada
  • I Komang Kari
  • Abdul Hamid
Keywords: children, neurological impairment, premature, hyperbilirubinemia

Abstract

Background In premature infants, the incidence of hyperbiliru-
binemia is still high. Bilirubin encephalopathy can develop without
marked hyperbilirubinemia.
Objective To know the incidence of neurological impairment in
premature with hyperbilirubinemia and the association between
neurological impairment and serum unconjugated billirubin con-
centration.
Methods A retrospective study was conducted on 54 prematures
with history of hyperbilirubinemia and 54 without history of hyper-
bilirubinemia born between 1997 and 1998 and discharged from
Sanglah Hospital. Consecutive sampling was done. After univariate
analysis, multivariate analysis was used to identify the association
between serum unconjugated bilirubin concentration and neuro-
logical impairment at the adjusted age of 318 months.
Results There were statistically significant differences in mean of
age and neurological impairment between subjects with and with-
out hyperbilirubinemia (p<0.0001 and 0.026). In subjects with hy-
perbilirubinemia, univariate analysis showed significant differences
in means of serum unconjugated bilirubin concentration, gesta-
tional age, birth weight, and serum albumin concentration between
subject who had neurological impairment and who had no neuro-
logical impairment with p = 0.005; 0.001; 0.002; <0.0001, respec-
tively. Multivariate analysis found there were association between
neurological impairment and serum unconjugated bilirubin concen-
tration, gestational age, and serum albumin concentration with
p<0.0001; 0.004; and <0.0001, respectively.
Conclusion Neurological impairment in subject with hyperbiliru-
binemia was greater than subject without hyperbilirubinemia. Se-
rum unconjugated bilirubin concentration is one of three factors
that associated with neurological impairment

Author Biographies

Ida Bagus Subanada
Department of Child Health, Medical School, University of
Udayana, Sanglah Hospital, Denpasar.
I Komang Kari
Department of Child Health, Medical School, University of
Udayana, Sanglah Hospital, Denpasar.
Abdul Hamid
Department of Child Health, Medical School, University of
Udayana, Sanglah Hospital, Denpasar.

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Published
2016-10-10
How to Cite
1.
Subanada I, Kari I, Hamid A. Neurological impairment of children with history of prematurity and neonatal hyperbilirubinemia. PI [Internet]. 10Oct.2016 [cited 22May2024];43(2):59-5. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/660
Section
Articles
Received 2016-09-22
Accepted 2016-09-22
Published 2016-10-10