Airway reversibility in newly developed asthma in children
Keywords:
airway reversibility, asthma, cough, forced expiratory volume in 1 second (FEV1)
Abstract
Objective To determine factors influencing forced expiratory vol-ume in one second (FEV 1 ) reversibility in newly developed asthma
in children
Methods A cross sectional study was done on 52 patients aged 6-
14 years who were recruited from a longitudinal study of 161 newly
developed asthmatic children. Pre and post-bronchodilator FEV 1
were obtained to calculate the reversibility. Seven patients had to
perform peak expiratory volume (PEV) variability before recruited.
Some variables including sex, age, height, onset of asthma, fre-
quency of asthma attacks at the time of the test were analyzed to
evaluate their roles in the outcome of FEV 1 reversibility using paired
sample t-test, Pearson’s correlation coefficient, and multi regres-
sion analysis.
Results Mean pre- and post-bronchodilator FEV 1 were 1.14 (SD
0.24) and 1.31 (SD 0.28), respectively. FEV 1 reversibility ranged
between 6%-36%. Bivariate analyses demonstrated significant cor-
relation between either cough (p=0.031) or symptom-free (p=0.041)
and the airway reversibility. Multivariate analysis showed that cough
was an important factor influencing airway reversibility (p=0.0246).
Conclusion Cough is an important influencing factor of the air-
way reversibility
References
1. Behrman RE, Kliegman R, Arvin AM. Textbook of pedi-
atrics. Philadelphia: WB Saunders Co; 1996. p. 628-40.
2. Bierman CW, Pearlman DS. Asthma. In: Kendig EL,
Chernick V, editors. Disorders of respiratory tract in chil-
dren. Philadelphia: WB Saunders Co; 1990. p. 557-96.
3. Wenzel SE, Larsen GL. Assessment of lung function:
pulmonary function testing. In: Bierman, editor. Al-
lergy, asthma, and immunology from infancy to adult-
hood. 3 rd ed. Philadelphia: WB Saunders Co; 1996. p.
157-71.
4. Weiss ST. Asthma epidemiology: risk factors and natu-
ral history. In: Bierman, editor. Allergy, asthma, and
immunology from infancy to adulthood. 3 rd ed. Phila-
delphia: WB Saunders Co; 1996. p. 472-81.
5. Dinwiddie R. Diagnosis and management of pediatric
respiratory disease. New York: Churchill Livingatone
Inc; 1997. p. 167-93.
6. Kanner RE. Spirometry in children. Methodology for
obtaining optimal result for clinical and epidemiologic
studies. Am Rev Respir Dis 1983;127:720-4.
7. Pfaff JK, Morgan WJ. Pulmonary function in infants
and children. Pediatr Clin North. Am 1984;9:402-22.
8. Enright PL, Lebowitz, Cockroft DW. Physiologic mea-
sures: pulmonary function tests. Asthma outcome. Am
J Respir Crit Care Med 1994;149(2Pt2):9-18.
9. Haddad GG, Fontan JJP. Respiratory function and ap-
proach to respiratory disease. In: Nelson WE, editor.
Textbook of pediatrics. 15 th ed. Philadelphia: WB
Saunders Co; 1996. p. 1170-85.
10. Godfrey S. Functional differences between the lungs
of normal and asthmatic children. In: Tinkelman DG,
Falliers CJ, Naspitz CK, editors. Childhood asthma
pathophysiology and treatment. New York: Marcel
Dekker Inc; 1987. p. 1-20.
11. Shapiro GG, Bierman CW. Presentation of asthma in chil-
dren: differential diagnosis. In: Tinkelman DG, Falliers CJ,
Naspilz CK. Childhood asthma pathophysiology and treat-
ment. New York: Marcel Dekker Inc; 1987. p. 203-26.
12. Bone RG. Goals of asthma management. A step care
approach. Chest 1996;109:1056-65.
13. Pare PD, Lawson LM, Brooks LA. Pattern of response
to inhaled bronchodilators in asthmatic. Am Rev
Respir Dis 1983;127:680-5.
14. Selroos O. Lofroos AB, Pietinalho A, Riska H. Compari-
son of terbutaline and placebo from a pressurised me-
tered dose inhaler and a dry powder inhaler in a subgroup
of patients with asthma. Thorax 1994:49:1228-30.
15. Zureik M, Liard R, Segala C, Henry C, Korobaeff M,
Neukirch F. Peak expiratory flow rate variability in
population surveys. Does the number of assessments
matter? Chest 1995;107:418-23.
16. Gautrin D. Comparison between peak expiratory flow rates
(PEFR) and FEV 1 in the monitoring of asthmatic subjects
at an outpatient clinic. Chest 1994;106:1419-260.
17. Pearlman DS, Lemanske RF Jr. Asthma (bronchial
asthma): principles of diagnosis and treatment. In:
Bierman, editor. Allergy, asthma, and immunology from
infancy to adulthood. 3 rd ed. Philadelphia: WB
Saunders Co; 1996. p. 484-96.
18. McBride JT, Wohl ME. Pulmonary function tests.
Pediatr Clin North Am 1979;26:537-51.
19. Neijens HJ, Duiverman EJ, Kerrebijn KF. Bronchial re-
sponsiveness in children. Pediatr Clin North Am
1986;30:530-44.
atrics. Philadelphia: WB Saunders Co; 1996. p. 628-40.
2. Bierman CW, Pearlman DS. Asthma. In: Kendig EL,
Chernick V, editors. Disorders of respiratory tract in chil-
dren. Philadelphia: WB Saunders Co; 1990. p. 557-96.
3. Wenzel SE, Larsen GL. Assessment of lung function:
pulmonary function testing. In: Bierman, editor. Al-
lergy, asthma, and immunology from infancy to adult-
hood. 3 rd ed. Philadelphia: WB Saunders Co; 1996. p.
157-71.
4. Weiss ST. Asthma epidemiology: risk factors and natu-
ral history. In: Bierman, editor. Allergy, asthma, and
immunology from infancy to adulthood. 3 rd ed. Phila-
delphia: WB Saunders Co; 1996. p. 472-81.
5. Dinwiddie R. Diagnosis and management of pediatric
respiratory disease. New York: Churchill Livingatone
Inc; 1997. p. 167-93.
6. Kanner RE. Spirometry in children. Methodology for
obtaining optimal result for clinical and epidemiologic
studies. Am Rev Respir Dis 1983;127:720-4.
7. Pfaff JK, Morgan WJ. Pulmonary function in infants
and children. Pediatr Clin North. Am 1984;9:402-22.
8. Enright PL, Lebowitz, Cockroft DW. Physiologic mea-
sures: pulmonary function tests. Asthma outcome. Am
J Respir Crit Care Med 1994;149(2Pt2):9-18.
9. Haddad GG, Fontan JJP. Respiratory function and ap-
proach to respiratory disease. In: Nelson WE, editor.
Textbook of pediatrics. 15 th ed. Philadelphia: WB
Saunders Co; 1996. p. 1170-85.
10. Godfrey S. Functional differences between the lungs
of normal and asthmatic children. In: Tinkelman DG,
Falliers CJ, Naspitz CK, editors. Childhood asthma
pathophysiology and treatment. New York: Marcel
Dekker Inc; 1987. p. 1-20.
11. Shapiro GG, Bierman CW. Presentation of asthma in chil-
dren: differential diagnosis. In: Tinkelman DG, Falliers CJ,
Naspilz CK. Childhood asthma pathophysiology and treat-
ment. New York: Marcel Dekker Inc; 1987. p. 203-26.
12. Bone RG. Goals of asthma management. A step care
approach. Chest 1996;109:1056-65.
13. Pare PD, Lawson LM, Brooks LA. Pattern of response
to inhaled bronchodilators in asthmatic. Am Rev
Respir Dis 1983;127:680-5.
14. Selroos O. Lofroos AB, Pietinalho A, Riska H. Compari-
son of terbutaline and placebo from a pressurised me-
tered dose inhaler and a dry powder inhaler in a subgroup
of patients with asthma. Thorax 1994:49:1228-30.
15. Zureik M, Liard R, Segala C, Henry C, Korobaeff M,
Neukirch F. Peak expiratory flow rate variability in
population surveys. Does the number of assessments
matter? Chest 1995;107:418-23.
16. Gautrin D. Comparison between peak expiratory flow rates
(PEFR) and FEV 1 in the monitoring of asthmatic subjects
at an outpatient clinic. Chest 1994;106:1419-260.
17. Pearlman DS, Lemanske RF Jr. Asthma (bronchial
asthma): principles of diagnosis and treatment. In:
Bierman, editor. Allergy, asthma, and immunology from
infancy to adulthood. 3 rd ed. Philadelphia: WB
Saunders Co; 1996. p. 484-96.
18. McBride JT, Wohl ME. Pulmonary function tests.
Pediatr Clin North Am 1979;26:537-51.
19. Neijens HJ, Duiverman EJ, Kerrebijn KF. Bronchial re-
sponsiveness in children. Pediatr Clin North Am
1986;30:530-44.
Published
2016-09-24
How to Cite
1.
Harsono A, Kusumawardani S, MS M, Santosa G. Airway reversibility in newly developed asthma in children. PI [Internet]. 24Sep.2016 [cited 26Apr.2024];43(1):1-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/648
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Received 2016-09-21
Accepted 2016-09-21
Published 2016-09-24
Accepted 2016-09-21
Published 2016-09-24
