Correlation between gut pathogens and fecal calprotectin levels in young children with acute diarrhea

Main Article Content

Yanever Angela Lam
Sarah M. Warouw
Audrey M.I. Wahani
Jeanette I.C. Manoppo
Praevilia Margareth Salendu


Background In cases of acute diarrhea, it is difficult to distinguish
between bact erial and non-bacterial causes . Increased fecal
calprotectin (f-CP) level is a marker of neutrophil migration in the
intestinal lumen and is associated with intes tinal inflammation.
Previous studies reported an increase in f-CP levels in children
with acute diarrhea, which is caused by bacteria, but only few
have studied the relationship between intestinal pathogens with
f-CP levels in acute diarrhea.
Objective To assess for a correlation between gut pathogens and
fecal calprotectin levels in children with acute diarrhea.
Methods We conducted a cross-sectional study between July
to November 2012 on children aged 1-5 ye ars with acute
diarrhea, and underwent routine blood tests, stool microscopy,
f-CP tests, and stool cultures. We used a simple linear regression
and correlation analysis with a significance level of P< 0.05.
Results Forty-two children enrolled in this study. The mean age of
subjects was 2.27 (SD 134) years. Theirmeanf-CP level was 93.88
(SD 14.68) μg/g. On microscopic stool examination, 26 patients
( 61.9%) had positive leukocytes, 1 had Ancy lo stoma duodenale, 1
had Ascaris lumbricoides, and 2 had Blastocystis hominis. Positive
stool cultures were found in 14 children (33.3%) with acute
diarrhea. There was a significant positive correlation between gut
pathogens and f-CP levels (r=0.605; P< 0.0001).
Conclusion In young children with acute diarrhea, the average
f-CP levels are higher in those with positive intestinal pathogens.

Article Details

How to Cite
Lam Y, Warouw S, Wahani A, Manoppo J, Salendu P. Correlation between gut pathogens and fecal calprotectin levels in young children with acute diarrhea. PI [Internet]. 31Aug.2014 [cited 28Sep.2020];54(4):193-. Available from:
Received 2016-09-16
Accepted 2016-09-16
Published 2014-08-31


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