Main Article Content
between genetic and environmental factors. The possible effects
of immunization, as one of environmental factors, on atopy remain
a matter of controversy.
Objective We conducted an observational clinical epidemiology
to find out the protective effect of high vaccination coverage to
atopy in children.
Methods During January through March 2006, 150 of749 children
at Garuda, Padasuka, and Babakan Sari Primary Health Care in
Bandung were randomized from group with and without family
history of atopic disease. Atopy derived from skin prick test and
total serum lgE was evaluated. Atopy was defined as a positive
skin test to any of the eight allergens tested. The immunizations
were recorded from Kartu Menuju Sehat (KMS). Statistical analyses
included Chi square to compare prevalence, independent T-test
and Mann-Whitney to compare mean.
Results Atopy was found in 28.2% of284 subjects, of which 32.4%
with and 23.9% without a family history of atopic disease. The
median of total serum lgE level was higher in children with family
history of atopic disease and in atopy children. Children were
grouped according to total dose of basic immunizations (0-17 and
2: 18) based on Program Pengembangan Imunisasi (PPI). There was
nonsignificant association between total doses of immunization
and atopy. Even though no statistically significant, the cumulative
immunization doses were inversely related to the median of total
serum IgE level.
Conclusions The immunization coverage has not decreased atopy
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