Correlation between serum albumin and creatinine levels in children with nephrotic syndrome
Keywords:
idiopathic nephrotic syndrome, hypoalbuminemia, serum creatinine, glomerular filtration rate
Abstract
Background Nephrotic syndrome is a glomerular disordercharacterized by massive proteinuria, hypoalbuminemia, edema,
and hyperlipidemia. Hypoalbuminemia in nephrotic syndrome
leads to hypovolemia, a decrease in renal perfusion and glomerular
filtration rate. Serum creatinine level reflects the glomerular
filtration rate.
Objective The aim of this study was to determine the correlation
between serum albumin and creatinine levels in children with
nephrotic syndrome.
Methods A cross-sectional study was carried out on children with
idiopathic nephrotic syndrome, aged between 1 to 14 years old,
admitted to Pediatric Department in Hasan Sadikin Hospital
from January 2001 to September 2007. We used data from
patients' medical records to obtain serum albumin and creatinine
levels during nephrotic stage. Statistical analysis using Pearson
correlation test was performed to establish the correlation between
serum albumin and creatinine levels. The type of correlation was
determined by regression analysis.
Results Subjects were 113 children, consisted of 81 boys (72%)
with mean of age 6.8 (SD 3.3) years. Mean of serum albumin and
creatinine levels were 1.4 (SD 0.4) g/dL and 0.7 (SD 0.4) mg/
dL, respectively. Analysis using Pearson correlation test showed
a moderate (r=-0.478) significant correlation (P<O.Ol) between
serum albumin and creatinine levels in children with nephrotic
syndrome. Regression analysis suggested a negative linear
relationship between serum albumin level as the independent
variable (X) and serum creatinine level as the dependent variable
(Y) by using equation Y = 1.328-0.460X.
Conclusion In patients with nephrotic syndrome there is a
moderate negative correlation between serum albumin and
creatinine levels.
References
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histopatology from clinical and laboratory characteristics at
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syndrome. In: Barrat TM, Avner ED, Harmon WE, editors.
Pediatric nephrology. 4th ed. Baltimore: Lippincott Williams
& Wilkins, 1999; p. 731-47.
2. Vogt BA, Avner ED. Nephrotic syndrome. In: Behrman
RE, Kliegman RM, Jenson HB, editors. Nelson textbook
of pediatrics. 17th ed. Philadelphia: WB Saunders, 2004; p.
1753-7.
3. Vogt BA, Avner ED. Acute renal failure. In: Behrman RE,
Kliegman RM, Jenson HB, editors. Nelson textbook of
pediatrics. 17th ed. Philadelphia: WB Saunders, 2004; p.
1767-71.
4. Koomans HA. Patophysiology of acute renal failure in
idiopathic nephrotic syndrome. Nephrol Dial Transplant.
2001;16:221-4.
5. Berg U, Bohlin AB. Renal hemodynamics in minimal change
nephrotic syndrome in childhood. Int J Pediatr Nephrol.
1982;3: 187-92.
6. Lowenborg EKM, Berg UB. Influence of serum albumin
on renal function in nephrotic syndrome. Pediatr Nephrol.
1999;13:19-25.
7. Guasch A, Myers BD. Determinants of glomerular hypo-
filtration in nephrotic patients with minimal change
nephropathy. JAm Soc Nephrol. 1994;4: 1571-81.
8. Holt RCL, Connell JE, Addison GM. Reference data for
paediatric nephrology. In: Nicholas JA, Postlethwaite RJ,
editors. Clinical paediatric nephrology. Jrd ed. New York:
Oxford, 2003; p. 493-509.
9. Yared A, Ichikawa I. Glomerular circulation and function.
In: Barrat TM, Avner ED, Harmon WE, editors. Pediatric
nephrology. 4th ed. Baltimore: Lippincott Williams & Wilkins,
1999; p. 39-55.
10. Machin D, Campbell MJ. Statistical tables for the design
of clinical trials. London: Blackwell scientific publication;
1987.
11. Haycock G. The child with idiopathic nephrotic syndrome.
In: Nicholas JA, Postlethwaite RJ, editors. Clinical paediatric
nephrology. Jrd ed. New York: Oxford, 2003; p. 341-66.
12. Kher KK. Evaluation of renal functions. In: Kher KK, Makker
SP, editors. Clinical pediatric nephrology. New York: McGraw-
Hill Inc, 1992; p. 3-21.
13. Zar JH. Biostatistical analysis. 4th ed. New Jersey: Prentice
Hall; 1999.
14. Nash MA, Edelmann CM, Bernstein J, Barnett HL. The
nephrotic syndrome. In: Edelmann CM, Bernstein J, Meadow
RS, Spitzer A, Travis LB, editors. Pediatric kidney disease. 2nd
ed. Boston: Little Brown and Company, 1992; p. 1247-66.
15. ISKDC. Nephrotic syndrome in children: Prediction of
histopatology from clinical and laboratory characteristics at
time of diagnosis. Kidney Int. 1978; 13:159-65.
Published
2016-09-15
How to Cite
1.
Sapartini G, Rachmadi D, Garna H. Correlation between serum albumin and creatinine levels in children with nephrotic syndrome. PI [Internet]. 15Sep.2016 [cited 27Apr.2024];48(6):354-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/629
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Received 2016-09-14
Accepted 2016-09-14
Published 2016-09-15
Accepted 2016-09-14
Published 2016-09-15
