Association between serum vitamin D level and tuberculosis in children
Keywords:
tuberculosis, vitamin D, children
Abstract
Background A possible association between vitamin 0 andtuberculosis has been described. In adult, vitamin 0 is considered
to have a role in protecting tuberculosis. On the other hand,
tuberculosis infection can decrease serum vitamin 0 level.
Objective To find out the difference between serum vitamin 0
level in children with and without tuberculosis, and to find the
association of serum vitamin 0 level with tuberculosis.
Methods A cross sectional study was conducted in Cibabat Hospital,
Ban dung from July to October 2007. We selected children :S 14
years, diagnosed as tuberculosis, and had positive response after
two month treatment; for control we selected randomly siblings
or neighbors who didn't have tuberculosis. We excluded children
with liver abnormalities and immunocompromized children.
Mann-Whitney test and OR method with 95% confidence interval
was used to analyze the data.
Results Thirty-nine children with tuberculosis (21 boys, 18 girls)
and 39 children without tuberculosis (19 boys, 20 girls) as were
enrolled. Mean serum vitamin 0 level of children with and without
TB were 4 7 (SO 25) pmol/L and 125 (SO 3 7) pmol/L, respectively
(P=O.OOl). All children without tuberculosis had normal vitamin
0 level while of those with tuberculosis, 14 children had normal
level and 25 children were deficient (corrected OR: 139, 95%CI
8 to 238).
Conclusion Serum vitamin 0 level is low in children with
tuberculosis.
References
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D, Paillard F, et al. Vitamin D metabolism by alveolar immune
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clinical manifestation. Eur Respir J. 1994;7:1103-10.
13. Hmama Z, Nandan D, Sky LS, Kruston KL, Velt PH,
Reiner NE. 1a,25-dihydroxyvitamin D3 -induced myeloid
cell differentistion is regulsted by a vitamin d receptor -
phosphatidylinositol3-kinase signaling complex. J Exp Med.
1999;190: 1583-94.
14. Sly LM, Lopez M, Nauseef WM, Reiner NE. 1a,25-
dihydroxyvitamin d3-induced monocyte antimycobacterial
activity is regulated by phosphatidylinositol 3-kinase and
mediated by the nadph-dependent phagocyte oxidase. J Biol
Chem. 2001;276:35482-93.
15. UKK Respirologi PP IDAI. Pedoman nasional tuberkulosis
anak. Jakarta: IDAI; 2007.
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1,25(0H)2D3 production by T lymphocytes and alveolar
macrophages recovered by lavage from normocalcemic
patients with tuberculosis. J Clin Invest. 1990;85: 1588-93.
17. Davies PDO, Grange JM. Factors affecting susceptibility and
resistance to tuberculosis. Thorax.2001 ;56 Suppl 2:ii23-9.
18. Jablonski NG, Chaplin G. The evolution of human skin
coloration. J Human Evolution. 2000;39:57 -106.
19. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, et
al. Vitamin D3-triggered antimicrobial response-another
pleintopic effect beyond mineral and bone metabolism. J Am
Soc Nephrol. 2007; 17:2949-53.
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BP. Vitamin D receptor fok1 polymorphism and blood
lead concentration in children. Environ Health Perspect.
2003; 13:1665-9.
World Health Organization; 2007.
2. World Health Organization. Tuberculosis in Indonesia.
Geneva: World Health Organization; 2007.
3. Mandalakas AM, Starke JR. Tuberculosis and non
tuberculosis mycobacterial disease. In: Chernick V, Boat
TF, Wilmott RW, Bush A, editors. Kendig's disorders of
the respiratory tract in children, 7'h edition. Philadelphia:
Saunders, 2006; p. 507-29.
4. Young J, O'Connor ME. Risk factors associated with latent
tuberculosis infection in Mexican American children.
Pediatrics. 2005;115:e647-53.
5. Tocque K, Bellis MA, Beeching NJ, Davies PDQ. A
case-control study of lifestyle risk factors associated with
tuberculosis in Liverpool, North-West England. Eur Respir
J. 2001;18:959-64.
6. Rhodes SG, Terry LA, Hope J, Hewinson RG, Vordermeier
HM. 1 ,25-dihydroxyvitamin D3 and development of
tuberculosis in Cattle. Clin Diag Lab Immunol. 2003;
10:1129-35.
7. Cadranel JL, Hance AJ, Milleron B, Paillard F. Vitamin
D metabolism in tuberculosis. Am Rev Respir Dis.
1988; 138:984-9.
8. Villamor E, Kupka R, Fawzi W Vitamins. In: Walker WA,
Watkins JB, Duggan C, editors. Nutrition in pediatrics basic
science and clinical application, Jrd edition. Hamilton: BC
Decker Inc, 2003; p. 111-33.
9. Shaw NJ, Pal BR. Vitamin D deficiency in UK Asian
families: activating a new concern. Arch Dis Child.
2002;86: 14 7-9.
10. McKenna MJ. Differences in vitamin D status between
countries in young adults and the elderly. Am J Med.
1992;93:69-77.
11. Omerod LP, Charlett A, Gilham C, Darbyshire JH, Watson
JM. Geographical distribution of tuberculosis notification in
national surveys of England and Wales in 1988 and 1993:
report of the public health laboratory service/British Thoracic
Society/Department of Health Collaborative Group. Thorax.
1998;53: 176-81.
12. CadranelJL, Garabedian M, Milleron B, Guillozzo H, Valeyre
D, Paillard F, et al. Vitamin D metabolism by alveolar immune
cells in tuberculosis: correlation with calcium metabolism and
clinical manifestation. Eur Respir J. 1994;7:1103-10.
13. Hmama Z, Nandan D, Sky LS, Kruston KL, Velt PH,
Reiner NE. 1a,25-dihydroxyvitamin D3 -induced myeloid
cell differentistion is regulsted by a vitamin d receptor -
phosphatidylinositol3-kinase signaling complex. J Exp Med.
1999;190: 1583-94.
14. Sly LM, Lopez M, Nauseef WM, Reiner NE. 1a,25-
dihydroxyvitamin d3-induced monocyte antimycobacterial
activity is regulated by phosphatidylinositol 3-kinase and
mediated by the nadph-dependent phagocyte oxidase. J Biol
Chem. 2001;276:35482-93.
15. UKK Respirologi PP IDAI. Pedoman nasional tuberkulosis
anak. Jakarta: IDAI; 2007.
16. Cadranel JL, Garabedian M, Milleron B, Hance AJ.
1,25(0H)2D3 production by T lymphocytes and alveolar
macrophages recovered by lavage from normocalcemic
patients with tuberculosis. J Clin Invest. 1990;85: 1588-93.
17. Davies PDO, Grange JM. Factors affecting susceptibility and
resistance to tuberculosis. Thorax.2001 ;56 Suppl 2:ii23-9.
18. Jablonski NG, Chaplin G. The evolution of human skin
coloration. J Human Evolution. 2000;39:57 -106.
19. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, et
al. Vitamin D3-triggered antimicrobial response-another
pleintopic effect beyond mineral and bone metabolism. J Am
Soc Nephrol. 2007; 17:2949-53.
20. Haynes EN, KalkwarfHJ, Hornung R, Wenstrup R, Lanphear
BP. Vitamin D receptor fok1 polymorphism and blood
lead concentration in children. Environ Health Perspect.
2003; 13:1665-9.
Published
2016-09-15
How to Cite
1.
Syafii A, Sukadi A, Setiabudiawan B. Association between serum vitamin D level and tuberculosis in children. PI [Internet]. 15Sep.2016 [cited 23Dec.2024];48(6):350-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/628
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Received 2016-09-14
Accepted 2016-09-14
Published 2016-09-15
Accepted 2016-09-14
Published 2016-09-15
