Association between serum vitamin D level and tuberculosis in children
Keywords:
tuberculosis, vitamin D, children
Abstract
Background A possible association between vitamin 0 andtuberculosis has been described. In adult, vitamin 0 is considered
to have a role in protecting tuberculosis. On the other hand,
tuberculosis infection can decrease serum vitamin 0 level.
Objective To find out the difference between serum vitamin 0
level in children with and without tuberculosis, and to find the
association of serum vitamin 0 level with tuberculosis.
Methods A cross sectional study was conducted in Cibabat Hospital,
Ban dung from July to October 2007. We selected children :S 14
years, diagnosed as tuberculosis, and had positive response after
two month treatment; for control we selected randomly siblings
or neighbors who didn't have tuberculosis. We excluded children
with liver abnormalities and immunocompromized children.
Mann-Whitney test and OR method with 95% confidence interval
was used to analyze the data.
Results Thirty-nine children with tuberculosis (21 boys, 18 girls)
and 39 children without tuberculosis (19 boys, 20 girls) as were
enrolled. Mean serum vitamin 0 level of children with and without
TB were 4 7 (SO 25) pmol/L and 125 (SO 3 7) pmol/L, respectively
(P=O.OOl). All children without tuberculosis had normal vitamin
0 level while of those with tuberculosis, 14 children had normal
level and 25 children were deficient (corrected OR: 139, 95%CI
8 to 238).
Conclusion Serum vitamin 0 level is low in children with
tuberculosis.
References
1. World Health Organization. 2007 Tuberculosis facts. Geneva:
World Health Organization; 2007.
2. World Health Organization. Tuberculosis in Indonesia.
Geneva: World Health Organization; 2007.
3. Mandalakas AM, Starke JR. Tuberculosis and non
tuberculosis mycobacterial disease. In: Chernick V, Boat
TF, Wilmott RW, Bush A, editors. Kendig's disorders of
the respiratory tract in children, 7'h edition. Philadelphia:
Saunders, 2006; p. 507-29.
4. Young J, O'Connor ME. Risk factors associated with latent
tuberculosis infection in Mexican American children.
Pediatrics. 2005;115:e647-53.
5. Tocque K, Bellis MA, Beeching NJ, Davies PDQ. A
case-control study of lifestyle risk factors associated with
tuberculosis in Liverpool, North-West England. Eur Respir
J. 2001;18:959-64.
6. Rhodes SG, Terry LA, Hope J, Hewinson RG, Vordermeier
HM. 1 ,25-dihydroxyvitamin D3 and development of
tuberculosis in Cattle. Clin Diag Lab Immunol. 2003;
10:1129-35.
7. Cadranel JL, Hance AJ, Milleron B, Paillard F. Vitamin
D metabolism in tuberculosis. Am Rev Respir Dis.
1988; 138:984-9.
8. Villamor E, Kupka R, Fawzi W Vitamins. In: Walker WA,
Watkins JB, Duggan C, editors. Nutrition in pediatrics basic
science and clinical application, Jrd edition. Hamilton: BC
Decker Inc, 2003; p. 111-33.
9. Shaw NJ, Pal BR. Vitamin D deficiency in UK Asian
families: activating a new concern. Arch Dis Child.
2002;86: 14 7-9.
10. McKenna MJ. Differences in vitamin D status between
countries in young adults and the elderly. Am J Med.
1992;93:69-77.
11. Omerod LP, Charlett A, Gilham C, Darbyshire JH, Watson
JM. Geographical distribution of tuberculosis notification in
national surveys of England and Wales in 1988 and 1993:
report of the public health laboratory service/British Thoracic
Society/Department of Health Collaborative Group. Thorax.
1998;53: 176-81.
12. CadranelJL, Garabedian M, Milleron B, Guillozzo H, Valeyre
D, Paillard F, et al. Vitamin D metabolism by alveolar immune
cells in tuberculosis: correlation with calcium metabolism and
clinical manifestation. Eur Respir J. 1994;7:1103-10.
13. Hmama Z, Nandan D, Sky LS, Kruston KL, Velt PH,
Reiner NE. 1a,25-dihydroxyvitamin D3 -induced myeloid
cell differentistion is regulsted by a vitamin d receptor -
phosphatidylinositol3-kinase signaling complex. J Exp Med.
1999;190: 1583-94.
14. Sly LM, Lopez M, Nauseef WM, Reiner NE. 1a,25-
dihydroxyvitamin d3-induced monocyte antimycobacterial
activity is regulated by phosphatidylinositol 3-kinase and
mediated by the nadph-dependent phagocyte oxidase. J Biol
Chem. 2001;276:35482-93.
15. UKK Respirologi PP IDAI. Pedoman nasional tuberkulosis
anak. Jakarta: IDAI; 2007.
16. Cadranel JL, Garabedian M, Milleron B, Hance AJ.
1,25(0H)2D3 production by T lymphocytes and alveolar
macrophages recovered by lavage from normocalcemic
patients with tuberculosis. J Clin Invest. 1990;85: 1588-93.
17. Davies PDO, Grange JM. Factors affecting susceptibility and
resistance to tuberculosis. Thorax.2001 ;56 Suppl 2:ii23-9.
18. Jablonski NG, Chaplin G. The evolution of human skin
coloration. J Human Evolution. 2000;39:57 -106.
19. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, et
al. Vitamin D3-triggered antimicrobial response-another
pleintopic effect beyond mineral and bone metabolism. J Am
Soc Nephrol. 2007; 17:2949-53.
20. Haynes EN, KalkwarfHJ, Hornung R, Wenstrup R, Lanphear
BP. Vitamin D receptor fok1 polymorphism and blood
lead concentration in children. Environ Health Perspect.
2003; 13:1665-9.
World Health Organization; 2007.
2. World Health Organization. Tuberculosis in Indonesia.
Geneva: World Health Organization; 2007.
3. Mandalakas AM, Starke JR. Tuberculosis and non
tuberculosis mycobacterial disease. In: Chernick V, Boat
TF, Wilmott RW, Bush A, editors. Kendig's disorders of
the respiratory tract in children, 7'h edition. Philadelphia:
Saunders, 2006; p. 507-29.
4. Young J, O'Connor ME. Risk factors associated with latent
tuberculosis infection in Mexican American children.
Pediatrics. 2005;115:e647-53.
5. Tocque K, Bellis MA, Beeching NJ, Davies PDQ. A
case-control study of lifestyle risk factors associated with
tuberculosis in Liverpool, North-West England. Eur Respir
J. 2001;18:959-64.
6. Rhodes SG, Terry LA, Hope J, Hewinson RG, Vordermeier
HM. 1 ,25-dihydroxyvitamin D3 and development of
tuberculosis in Cattle. Clin Diag Lab Immunol. 2003;
10:1129-35.
7. Cadranel JL, Hance AJ, Milleron B, Paillard F. Vitamin
D metabolism in tuberculosis. Am Rev Respir Dis.
1988; 138:984-9.
8. Villamor E, Kupka R, Fawzi W Vitamins. In: Walker WA,
Watkins JB, Duggan C, editors. Nutrition in pediatrics basic
science and clinical application, Jrd edition. Hamilton: BC
Decker Inc, 2003; p. 111-33.
9. Shaw NJ, Pal BR. Vitamin D deficiency in UK Asian
families: activating a new concern. Arch Dis Child.
2002;86: 14 7-9.
10. McKenna MJ. Differences in vitamin D status between
countries in young adults and the elderly. Am J Med.
1992;93:69-77.
11. Omerod LP, Charlett A, Gilham C, Darbyshire JH, Watson
JM. Geographical distribution of tuberculosis notification in
national surveys of England and Wales in 1988 and 1993:
report of the public health laboratory service/British Thoracic
Society/Department of Health Collaborative Group. Thorax.
1998;53: 176-81.
12. CadranelJL, Garabedian M, Milleron B, Guillozzo H, Valeyre
D, Paillard F, et al. Vitamin D metabolism by alveolar immune
cells in tuberculosis: correlation with calcium metabolism and
clinical manifestation. Eur Respir J. 1994;7:1103-10.
13. Hmama Z, Nandan D, Sky LS, Kruston KL, Velt PH,
Reiner NE. 1a,25-dihydroxyvitamin D3 -induced myeloid
cell differentistion is regulsted by a vitamin d receptor -
phosphatidylinositol3-kinase signaling complex. J Exp Med.
1999;190: 1583-94.
14. Sly LM, Lopez M, Nauseef WM, Reiner NE. 1a,25-
dihydroxyvitamin d3-induced monocyte antimycobacterial
activity is regulated by phosphatidylinositol 3-kinase and
mediated by the nadph-dependent phagocyte oxidase. J Biol
Chem. 2001;276:35482-93.
15. UKK Respirologi PP IDAI. Pedoman nasional tuberkulosis
anak. Jakarta: IDAI; 2007.
16. Cadranel JL, Garabedian M, Milleron B, Hance AJ.
1,25(0H)2D3 production by T lymphocytes and alveolar
macrophages recovered by lavage from normocalcemic
patients with tuberculosis. J Clin Invest. 1990;85: 1588-93.
17. Davies PDO, Grange JM. Factors affecting susceptibility and
resistance to tuberculosis. Thorax.2001 ;56 Suppl 2:ii23-9.
18. Jablonski NG, Chaplin G. The evolution of human skin
coloration. J Human Evolution. 2000;39:57 -106.
19. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, et
al. Vitamin D3-triggered antimicrobial response-another
pleintopic effect beyond mineral and bone metabolism. J Am
Soc Nephrol. 2007; 17:2949-53.
20. Haynes EN, KalkwarfHJ, Hornung R, Wenstrup R, Lanphear
BP. Vitamin D receptor fok1 polymorphism and blood
lead concentration in children. Environ Health Perspect.
2003; 13:1665-9.
Published
2016-09-15
How to Cite
1.
Syafii A, Sukadi A, Setiabudiawan B. Association between serum vitamin D level and tuberculosis in children. PI [Internet]. 15Sep.2016 [cited 26Apr.2024];48(6):350-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/628
Section
Articles
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Received 2016-09-14
Accepted 2016-09-14
Published 2016-09-15
Accepted 2016-09-14
Published 2016-09-15
