Relapse episodes in childhood primary nephrotic syndrome treated by alternate or three consecutive daily dose prednisone therapy
Keywords:
primary nephrotic syndrome, prednisone, alternate days, three consecutive days, relapse
Abstract
Background Prednison is still the drug of choice for the treatmentof nephrotic syndrome, especially for those with minimal change.
Methods of treatment to optimize the effectiveness and efficacy
are still in discussion.
Objectives To evaluate the episode of relapsing minimal change
nephrotic syndrome patients who received prednisone therapy by
alternate or by three consecutive dose methods.
Methods We performed a retrospective cohort study using medical
records of the patients with primary nephrotic syndrome admitted
to Division of Nephrology, Sardjito Hospital, Yogyakarta from
January 1995 to January 2005. Subjects were divided into two
groups, the first group treated with alternate days while the
second group with three consecutive days prednisone program.
Evaluation had been done to compare both treatment program
(alternate days or consecutive days).
Results Relapse episodes after six month recovery periods with
alternate days treatment was 33% while those with consecutive
days was as high as 83% (P>O.Ol).
Conclusion Alternate dose group has a lower relapse event
compared to three consecutive dose group in children with
nephrotic syndrome.
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syndrome. J Pediatr Nephrol. 2003; 18:1122-7.
2. Constantinescu AP, Shah HB, Foote EF, Weiss LS. Predicting
first-year relapses in children with nephrotic syndrome.
Pediatrics. 2000; 105:492-5.
3. Agraharkar M, Gala G, Gangakhedkar AK, Kalia A, Mullo
LL, Talavera F, et al. Nephrotic syndrome. Available from:
http://emedicine. medscape.com/article/244631-overview.
4. Wirya, IGN Wila. Penelitian beberapa aspek klinis dan
patologi anatomis sindrom nefrotik primer pada anak di
Jakarta [dissertation]. Jakarta: University of Indonesia;
1992.
5. Wirya, IGN Wila. Penatalaksanaan sindrom nefrotik primer
pada anak. In: Rauf S, Albar H, Adoe TH, Hasanuddin A,
editors. Naskah Lengkap Simposium Nasional Nefrologi
Anak VII. Ujungpandang: Ikatan Dokter Anak Indonesia
Sulawesi Selatan. p. 21-46.
6. Damanik MP, Yoshikawa N. Histopathological features of
primary nephrotic syndrome in children. Paediatr lndones.
1998;38(1-2) :S20-8.
7. Hodson EM, Knight JF, Willis NS, Craig JC. Corticosteroid
therapy in nephrotic syndrome: A meta-analysis of randomized
controlled trials. Arch Dis Child. 2000;83: 45-51.
8. Stephan R, Eberhard R. The nephrotic syndrome. NEJM.
1997 ;338: 1202-11.
9. Soliday E, Grey S, Lande NB. Behavioral effects of
corticosteroids in steroid sensitive nephrotic syndrome.
Pediatrics. 1999;104:1-4.
Published
2016-09-15
How to Cite
1.
Sujatno D, Damanik M, Suryantoro P. Relapse episodes in childhood primary nephrotic syndrome treated by alternate or three consecutive daily dose prednisone therapy. PI [Internet]. 15Sep.2016 [cited 23Dec.2024];48(6):338-1. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/623
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Received 2016-09-14
Accepted 2016-09-14
Published 2016-09-15
Accepted 2016-09-14
Published 2016-09-15
