Diagnostic accuracy of septic markers for neonatal sepsis

Main Article Content

Thermiany AS
W Retayasa
M Kardana
IN Lila

Abstract

Background Neonatal sepsis is a major cause of morbidity and
mortality. A positive blood culture is the gold standard for
diagnosis of neonatal sepsis. The signs and symptoms suggesting
neonatal sepsis are non-specific. There is no rapid and reliable
laboratory test findings for confirmation of etiologic diagnosis.
Clinical signs, symptoms, and laboratory examinations are not
perceived as sensitive or specific for diagnosis of sepsis.
Objective The purpose of this study was to evaluate the accuracy
of the septic markers for diagnosis of neonatal sepsis.
Methods Blood culture was used as gold standard to compare
septic markers to diagnose neonatal sepsis. Sensitivity, specificity,
positive predictive value (PPV), negative predictive value (NPV),
positive and negative likelihood ratio (LR), and accuracy were
calculated.
Results We identified 130 cases suspected of neonatal sepsis during
September 2005 until March 2006. Four patients were excluded
because of major congenital anomalies. The mean age was 2.2 days
and 51.6% were boys. We found fifty six (44.4%) neonates have
positive blood culture. All of septic markers had sensitivity more
than 80%. Immature to Total Neutrophil ratio (Iff) ratio had the
highest sensitivity (96.4%) and C-Reactive Protein (CRP) had the
lowest sensitivity (80.4o/o). Combination among leukocyte count,
thrombocyte, and Iff ratio had the highest sensitivity (sensitivity
was 85. 7%, specificity was 97.1 o/o, positive predictive value was
95.9%, negative predictive value was 89.5%, accuracy was 94.4%,
and positive likelihood ratio was 30.0).
Conclusion Septic markers can be used in the diagnostic
evaluation of neonates with suspected sepsis.

Article Details

How to Cite
1.
AS T, Retayasa W, Kardana M, Lila I. Diagnostic accuracy of septic markers for neonatal sepsis. PI [Internet]. 15Sep.2016 [cited 27Sep.2020];48(5):299-05. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/610
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Articles
Author Biographies

Thermiany AS

Department of Child Health, Medical School, University of
Udayana, Sanglah Hospital, Denpasar, Indonesia.

W Retayasa

Medical School, University of Udayana, Sanglah Hospital,
Denpasar, Indonesia

M Kardana

Department of Child Health, Medical School, University of
Udayana, Sanglah Hospital, Denpasar, Indonesia.

IN Lila

Department of Clinical Laboratory, Medical School, University
of Udayana, Sanglah Hospital , Denpasar, lndonesia.
Received 2016-09-12
Accepted 2016-09-12
Published 2016-09-15

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