The relationship between contact to cat and the development of asthma in children
Keywords:
asthma, contact to cat, risk, protective, children.
Abstract
Background Data suggesting history of direct or indirect contactto cats are either protective, has no effect or increase risk of
sensitization and asthma development.
Objective To determine the relationship between childhood
contact to cat and the development of asthma in children.
Methods A case control study was conducted in Denpasar since
December 2006 until Juli 2008. In this study, subjects with
asthma (cases group) were selected for comparisons to a series of healthy subjects without asthma (controls group). Forty-seven
subjects (3-12 years) with asthma were recruited and matched
(age and sex) with 4 7 healthy and non asthma controls. Data were collected using two kinds of questionnaires, i.e: ISAAC, ATS 78, and Robertson modification questionnaire from Medical School, University of Indonesia, which had been validated to determine asthma and asthma risk factors questionnaire. Data were analyzed as univariate by using chi-square or Fisher's exact test, and multivariate analysis by stepwise logistic regression model.
Results Result of univariate analysis showed that there were seven significant risk factors of asthma. Using multivariate analysis, contact to cat was significant risk factor for asthma [OR: 4.5 (95% CI 1.3 to 16.0), P= 0.020]. Other significant risk factors were; contact to cockroach [OR: 11.7 (95% CI 2.6 to 51.6), P= 0.001], use of kapok mattress [OR: 6.4 (95% CI 1.4 to 29.0), P= 0.015], passive smoker [OR: 4.7 (95% CI 1.3 to 17.0), P= 0.018], and atopic history [OR: 9.2 (95% CI 2.3 to 36.7), P= 0.002].
Conclusions There was a relationship between childhood contact
to cat and the development of asthma in children. Risk factors that statistically significant were; contact to cockroach, use of kapok mattress, passive smoker, and history of allergy in study subject.
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nokturnal pada anak. Presented at the Indonesian Pediatric
Respiratory Meeting I: Focus on Asthma, Jakarta August
8-10, 2003.
3. Sundaru H. Apa yang perlu diketahui ten tang asma? Jakarta:
Departemen Kesehatan Republik Indonesia, 2002 [cited 2005
Mar 12]. Available from: URL: http: //www.depkes.RI
4. Supriyatno B, Darmawan BS, Yangtjik K, Kartasaamita CB,
Wasatoro D, Naning R, et al. Asma bronkial, tata laksana
jangka panjang. In: Pusponegoro HD, Hadinegoro SRS,
Firmanda D, Tridjaja BAAP, Pudjiadi AH, Kosim MS, eta!,
editors. Standar pelayanan medis kesehatan anak. 1st ed.
Jakarta: IDAI, 2004; p. 341.
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6. Platts-Mills TAE. Indoor allergens. In: Adkinson NF,
Yunginger JW, Busse WW, Bochner BS, Holgate ST, Simon
FER, editors. Middleton's allergy principles and practice. Vol
II. 6'" ed. Philadelphia: Mosby, 2003; p. 557-9.
7. Vailes LD, Li Y, Bao Y, DeGroot H, Aalb RC, Chapman MD.
Fine specificity ofB-cell epitopes on Felis domesticus allergen I
(Fe! d I): Effect of reduction and alkylation or deglycosylation
on Fe! d 1 structure and antibody binding. J Allergy Clin
Immunol. 1994;93:22-33.
8. Wallenbeck I, Einarsson R. Identification of danderspecific
allergens in cat dandruff extract. Ann Alergy. 1987 ;59(2): 131-4.
9. Gronlund H, Bergeman T, Sandstrom K, Alvelius G,
Reininger R, Verdino P, et al. Formation of disulfide bond and
heterodimers of the major cat allergen Fel d 1 equivalent to
the natural allergen by expression in Escherichia coli. J Bioi
Chern. 2003;278(41):40144-51.
10. Stewart GA, Robinson C. Allergen structure and function.
In: Adkinson NF, Yunginger JW, Busse WW, Bochner
BS, Holgate ST, Simon FER, editors. Middleton's allergy
principles and practice. Vol. II. 6th ed. Philadelphia: Mosby,
2003; p. 593-4.
11. Dornelas DAD, Birmbaum J, Magalon C, Magno! JP,
Lanteaume A, Charpin D, et a!. Fel d 1 levels in cat anal
glands. Clin Exp Allergy. 1996;26: 178-80.
12. van Milligen FJ, Vroom TM, Aalbers RC. Presence of Felis
domesticus allergen I in the eat's salivary and lacrimal glands.
Int Arch Allergy Appl Immunol. 1990;92(4):375-8.
Published
2009-12-31
How to Cite
1.
Budha M, Naning R, Wati K. The relationship between contact to cat and the development of asthma in children. PI [Internet]. 31Dec.2009 [cited 27Apr.2024];49(6):379-6. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/605
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Received 2016-09-12
Accepted 2016-09-12
Published 2009-12-31
Accepted 2016-09-12
Published 2009-12-31
