Correlation between cord blood bilirubin level and incidence of hyperbilirubinemia in term newborns
Keywords:
cord blood, hyperbilirubinemia, early detection, newborn, jaundice
Abstract
Background Discharging healthy term newborns from thehospital after delivery at increasingly earlier postnatal ages has
recently become a common practice due to medical, social, and
economic reasons, however it contributes to readmission because
of jaundice.
Objective To investigate the correlation between level of cord
blood bilirubin and development of hyperbilirubinemia among
healthy term newborns.
Methods Prospective observational study was performed on
88 healthy term newborns. Cord blood was collected for the
total bilirubin, conjugated bilirubin, unconjugated bilirubin
level measurement and blood group test. Measurements of total
bilirubin, conjugated bilirubin, and unconjugated bilirubin were
repeated on the 5th day with serum sampling, or as soon as the
newborn appeared to be jaundice.
Results Subjects were categorized into hyperbilirubinemia and
non-hyperbilirubinemia newborns. There was a correlation
between cord blood and the 5th day bilirubin level. By ROC
analysis, cord blood bilirubin level of 2:2.54 md/dL was determined to have high sensitivity (90.5%), specificity of 85%, and accuracy of 86.4%.
Conclusions There is a correlation between cord blood bilirubin
level and hyperbilirubinemia in healthy term newborns. Cord
blood bilirubin level at or greater than 2.54 mg/dL can predict
the development of hyperbilirubinemia.
References
1. Maisels MJ. Jaundice. In: MacDonald MG, Seshia MMK,
Mullett MD, editor. Avery's neonatology. 6'h edition.
Philadelphia: Lippincott Williams & Wilkins, 2005; p.768-846.
2. Rubaltelli F, Dani C. Neonatal jaundice. In: Kurjak A,
Chervenak FA, editor. Textbook of perinatal medicine. 2nd
edition. New York: Informa Healthcare, 2006; p. 58-68.
3. Bhutani VK, Gourley GR, Adler S, Kreamer B, Dalin C,
Johnson LH. Noninvasive measurement of total serum
bilirubin in a multiracial predischarge newborn population
to assess the risk of severe hyperbilirubinemia. Pediatrics.
2000;106:e17.
4. Arimbawa IM, Soetjiningsih, Kari IK. Adverse effects of
hyperbilirubinemia on the development of healthy term
infants. Paediatr Indones. 2006;4 7:51-6.
5. Ip S, Chung M, Kulig J, O'Brien R, Sege R, Glicken S, et a!.
An evidence-based review of important issues concerning
neonatal hyperbilirubinemia. Pediatrics. 2004; 114:e 130-53.
6. Seidman DS, Stevenson DK, Ergaz Z, Gale R. Hospital
readmission due to neonatal hyperbilirubinemia. Pediatrics.
1995;96:727-9.
7. Bernaldo AJN, Segre CAM. Bilirubin dosage in cord blood:
could it predict neonatal hyperbilirubinemia? Sao Paulo Med
J. 2004;122:99-103.
8. Martin E. Cord blood sampling-cord blood tests [homepage
on the internet]. c2008 [cited 2008 May 29]. Available from:
www.medicineonline.com/topics/C/2/cord-blood-sampling/
cord-blood-tests/info/html.
9. Madan A, MacMahon JR, Stevenson DK. Neonatal
hyperbilirubinemia. In: Taeusch HW, Ballard RA, Gleason
CA, editor. Avery's diseases of the newborn. 8'h ed.
Philadelphia: WB Saunders Co, 2005; p. 1226-53.
10. Madan A, Wong RJ, Stevenson OK. Clinical features and
management of unconjugated hyperbilirubinemia in term and
near term infants [homepage on the internet]. c2008 [cited
2008 May 29]. Available from: https://store.utdol.com/app/
index.asp. uptodate.
11. Nicolaides KH, Sebire NJ. Management of the red cell
isoimmunized pregnancies. In: Kurjak A, Chervenak FA,
editor. Textbook of perinatal medicine. 2nd edition. New
York: Informa Healthcare, 2006; p. 1454-64.
12. American Academy of Pediatrics Subcommittee on
Hyperbilirubinemia: Management of hyperbilirubinemia in
the newborn infant 35 or more weeks of gestation. Pediatrics.
2004; 114:297-316.
13. Rostami N, Mehrabi Y. Identifying the newborns at risk for
developing significant hyperbilirubinemia by measuring cord
bilirubin levels. J Arab Neonatal Forum. 2005;2:81-5.
14. Sun G, Wang YL, Liang JF, Du LZ. Predictive value of
umbilical cord blood bilirubin level for subsequent neonatal
jaundice. Zhonghua Er Ke Za Zhi. 2007;45:848-52.
15. Rataj J, Kornacka M, Korman E. Usefulness of measuring
bilirubin level in cord blood for predicting hyperbilirubinemia
in newborns. Ginekol Pol. 1994;65:276-80.
16. Knudsen A. Prediction of the development of neonatal
jaundice by increased umbilical cord blood bilirubin. Acta
Paediatr. 1989;78:217-21.
17. Rostami N, Mehrabi Y. Identifying the newborns at risk for
developing significant hyperbilirubinemia by measuring cord
bilirubin levels. J Arab Neonatal Forum. 2005;2:81-5.
18. Newman TB, Xiong B, Gonzales VM, Escobar GJ. Prediction
and prevention of extreme neonatal hyperbilirubinemia in
a mature health maintenance organization. Arch Pediatr
Ado !esc Med. 2000; 154:1140-7.
19. Maisels MJ, Kring EA. Length of stay, jaundice and hospital
readmission. Pediatrics 1998; 101:995-8.
Mullett MD, editor. Avery's neonatology. 6'h edition.
Philadelphia: Lippincott Williams & Wilkins, 2005; p.768-846.
2. Rubaltelli F, Dani C. Neonatal jaundice. In: Kurjak A,
Chervenak FA, editor. Textbook of perinatal medicine. 2nd
edition. New York: Informa Healthcare, 2006; p. 58-68.
3. Bhutani VK, Gourley GR, Adler S, Kreamer B, Dalin C,
Johnson LH. Noninvasive measurement of total serum
bilirubin in a multiracial predischarge newborn population
to assess the risk of severe hyperbilirubinemia. Pediatrics.
2000;106:e17.
4. Arimbawa IM, Soetjiningsih, Kari IK. Adverse effects of
hyperbilirubinemia on the development of healthy term
infants. Paediatr Indones. 2006;4 7:51-6.
5. Ip S, Chung M, Kulig J, O'Brien R, Sege R, Glicken S, et a!.
An evidence-based review of important issues concerning
neonatal hyperbilirubinemia. Pediatrics. 2004; 114:e 130-53.
6. Seidman DS, Stevenson DK, Ergaz Z, Gale R. Hospital
readmission due to neonatal hyperbilirubinemia. Pediatrics.
1995;96:727-9.
7. Bernaldo AJN, Segre CAM. Bilirubin dosage in cord blood:
could it predict neonatal hyperbilirubinemia? Sao Paulo Med
J. 2004;122:99-103.
8. Martin E. Cord blood sampling-cord blood tests [homepage
on the internet]. c2008 [cited 2008 May 29]. Available from:
www.medicineonline.com/topics/C/2/cord-blood-sampling/
cord-blood-tests/info/html.
9. Madan A, MacMahon JR, Stevenson DK. Neonatal
hyperbilirubinemia. In: Taeusch HW, Ballard RA, Gleason
CA, editor. Avery's diseases of the newborn. 8'h ed.
Philadelphia: WB Saunders Co, 2005; p. 1226-53.
10. Madan A, Wong RJ, Stevenson OK. Clinical features and
management of unconjugated hyperbilirubinemia in term and
near term infants [homepage on the internet]. c2008 [cited
2008 May 29]. Available from: https://store.utdol.com/app/
index.asp. uptodate.
11. Nicolaides KH, Sebire NJ. Management of the red cell
isoimmunized pregnancies. In: Kurjak A, Chervenak FA,
editor. Textbook of perinatal medicine. 2nd edition. New
York: Informa Healthcare, 2006; p. 1454-64.
12. American Academy of Pediatrics Subcommittee on
Hyperbilirubinemia: Management of hyperbilirubinemia in
the newborn infant 35 or more weeks of gestation. Pediatrics.
2004; 114:297-316.
13. Rostami N, Mehrabi Y. Identifying the newborns at risk for
developing significant hyperbilirubinemia by measuring cord
bilirubin levels. J Arab Neonatal Forum. 2005;2:81-5.
14. Sun G, Wang YL, Liang JF, Du LZ. Predictive value of
umbilical cord blood bilirubin level for subsequent neonatal
jaundice. Zhonghua Er Ke Za Zhi. 2007;45:848-52.
15. Rataj J, Kornacka M, Korman E. Usefulness of measuring
bilirubin level in cord blood for predicting hyperbilirubinemia
in newborns. Ginekol Pol. 1994;65:276-80.
16. Knudsen A. Prediction of the development of neonatal
jaundice by increased umbilical cord blood bilirubin. Acta
Paediatr. 1989;78:217-21.
17. Rostami N, Mehrabi Y. Identifying the newborns at risk for
developing significant hyperbilirubinemia by measuring cord
bilirubin levels. J Arab Neonatal Forum. 2005;2:81-5.
18. Newman TB, Xiong B, Gonzales VM, Escobar GJ. Prediction
and prevention of extreme neonatal hyperbilirubinemia in
a mature health maintenance organization. Arch Pediatr
Ado !esc Med. 2000; 154:1140-7.
19. Maisels MJ, Kring EA. Length of stay, jaundice and hospital
readmission. Pediatrics 1998; 101:995-8.
Published
2009-12-31
How to Cite
1.
Satrya R, Effendi S, Gumida D. Correlation between cord blood bilirubin level and incidence of hyperbilirubinemia in term newborns. PI [Internet]. 31Dec.2009 [cited 13Nov.2024];49(6):349-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/600
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Received 2016-09-12
Accepted 2016-09-12
Published 2009-12-31
Accepted 2016-09-12
Published 2009-12-31
