Assessment of health-related quality of life in children with cancer using PedsQLâ„¢ (a preliminary study)
Keywords:
quality of life, cancer, children.
Abstract
Background Cancer in children can adversely affect theirdevelopments and growth. The assessment of health-related
quality of life (HRQL) will justifY its physical and psychological
effects.
Methods Seventy-seven subjects who underwent therapy were
assessed using the PedsQLâ„¢, which consisted of parent-proxy
reports and or child-self reports. PedsQLâ„¢ is assessments of
physical, social, emotional and role functions. The control
group was students with the same number and age as the sample group.
Results Children with cancer had lower HRQL than normal
healthy children (odds ratio 3. 7). Children with cancer who came
from low socio-economic families had lower social functions and
girls had tendencies to have lower quality oflife. Fathers' education had strong influence in children's quality of life. Leukemic patients had better quality of life than those of lymphoma and solid organ tumor. Group with age of diagnosis at 6-9 year old had lower HRQL compared with younger or older groups. The longer period of illness was, the more emotional function would improved. Despite of a good accordance between parents' and child's reports, parents usually had reports about having lower quality of life.
Conclusions Children's HRQL is influenced by clinical
characteristics and social-demographic variables differently.
Assessment of the children's HRQL is better done with parents
and or child as the source of information.
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psychological adjustment of children and parents. J Pediatr
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parent and adolescent reports describing the health-related
quality of life of adolescent treated for cancer. Int J Cancer
Suppl. 1999; 12:39-45.
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diagnosed with cancer and their mothers. Health Qual Life
Outcomes. 2005;3:29-33.
Behrman R, Jenson H, editor. Nelson text book of pediatrics.
18th ed. Philadelphia: Saunders, 2007; p. 2097-100.
2. Jannoun L, Chessels JM. Long-term psychological effects
of childhood leukemia and its treatment. Pediatr HematolOncol.
1987;4:292-308.
3. Apajasalo M, Sintonen H. Slimes M. Healthy-related quality
of life of adults surviving malignancies. Eur J Cancer. 1996;32: 1354-8.
4. Von Essen L. Enskar K. Kreufger A. Self-esteem, depression
and anxiety among Swedish children and adolescents on and
off cancer treatment. Acta Paediatr. 2000;89:229-36.
5. Boman K. Assessing psychological and health-related quality
of life (HRQL) late effects after childhood cancer. Acta
Paediatr. 2007;96:1265-8.
6. Hudson M,Mertens A,Yasui Y. Health status of adult
long-term survivors of childhood cancer: a report from the
childhood cancer survivor study. JAMA. 2003; 12:1583-92.
7. Parsons S. Evaluation of quality of life of childhood cancer
survivors: a methodological conundrum. Medical and Pediatr
Oncol Suppl. 1998; 1:46-53.
8. Varni J. Burwinkle T. Katz E. The PedsQLâ„¢ in pediatric
cancer reliability and validity of the pediatric quality of life
inventory generic core scales, multidimensional fatigue scale,
and cancer module. Cancer. 2002;94:2090-106.
9. Kreider S, Kreider M. Quality oflife in children with cancer:
definition, assessment and results. In: Kreider S, Weyl Ben
Arush M, editors. Psychosocial aspects of pediatric oncology.
England: John Wiley & Son, 2004; p.139-53.
10. Banks BA, Barrowman NJ, Klaassen R. Health-related quality
of life: changes in children undergoing chemotherapy. J
Pediatr Hematol Oncol. 2008;30:292-7.
11. Upton P, Eiser C, Cheung I, Hutchings HA, Jenney M,
Maddocks A, et a!. Measurement properties of the UK
English version of the pediatric quality oflife inventoryâ„¢4.0
(PedsQLâ„¢) generic core scales. Health Qual Life Outcomes.
2005;3:22-8.
12. Scarpelli AC, Paiva SM, Pordeus lA, Varni JW, Allison
PJ. Measurement properties of the Brazilian version of the
pediatric quality oflife inventory (PedsQL â„¢) cancer module
scale. Health Qual Life Outcomes. 2008;6: 7-17.
13. Wu E, Robinson LL, Jenney ME, Rockwood TH, Feusner
J, Friedman D, et al. Assesssment of healt-related quality
of life of adolescent cancer patients using the MinneapolisManchester Quality of Life Adolescent. Pediatr Blood Cancer. 2007 ;48:678-86.
14. Landolt M. Vollrath M. Niggli F. Health-related quality oflife
in children with newly diagnosed cancer: a one year follow-up
study. Health Qual Life Outcomes. 2006;4:63-70.
15. Kazak A, Christakis D, Alederfer M, Coiro M. Young
adolescent cancer survivors and their parents: adjustment,
learning problems, and gender. J Fam Psycho!. 1998;3:23-3.
16. Mulhern R, Wasserman A, Friedman A. Social competence
and behavioral adjustment of children who are long-term
survivors of cancer. Pediatrics. 1989;883: 18-25.
17. Zebrack B, Zeltzer L, Whitton J. Psychological outcomes in
long-term survivors of childhood leukemia, hodgkin's disease,
and non-hodgkin's lymphoma: a report from the childhood
cancer survivor study. Pediatrics. 2002; 110:42-52.
18. Magal-vardi 0, Laor N, Toren A. Psychiatric morbidity and
quality oflife in children with malignancies and their parents.
J Nerv Mental Dis. 2004; 192:872-5.
19. Meeske K, Katz ER, Palmer SN, Burwinkle T, Varni JW.
Parent proxy-reported health-related quality of life and
fatigue in pediatric patients diagnosed with brain tumors and
acute lymphoblastic leukemia. Cancer. 2004; 101:16-25.
20. Marcel A V. Adolescence. In: Kliegman R, Behrman R, Jenson
H, editor. Nelson textbook of pediatrics. lS'h ed. Philadelphia:
Saunders, 2007; p. 60-5.
21. Swayer M, Antoniou G, Toogood I, Rice M, Baghurst
M. Childhood cancer: a 4-year prospective study of the
psychological adjustment of children and parents. J Pediatr
Hematol Oncol. 2003;3:214-20.
22. Sawyer M, Antoniou G, Toogood I, Rice M. A comparison of
parent and adolescent reports describing the health-related
quality of life of adolescent treated for cancer. Int J Cancer
Suppl. 1999; 12:39-45.
23. Eiser C, Eiser RJ, Stride CB. Quality oflife in children newly
diagnosed with cancer and their mothers. Health Qual Life
Outcomes. 2005;3:29-33.
Published
2009-12-31
How to Cite
1.
Susanto lvony, Soedjatmiko S, Putra S. Assessment of health-related quality of life in children with cancer using PedsQLâ„¢ (a preliminary study). PI [Internet]. 31Dec.2009 [cited 13Nov.2024];49(6):330-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/597
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Received 2016-09-12
Accepted 2016-09-12
Published 2009-12-31
Accepted 2016-09-12
Published 2009-12-31
