Role of sublingual immunotherapy and probiotics in clinical improvements of childhood asthma

Main Article Content

Mira lrmawati
Anang Endaryanto
Arijanto Harsono


Background Sublingual immunotherapy (SLIT) is an effective
secondary prevention to improve natural course of asthma. Its
efficacy is limited to allergic asthma caused by inhalant allergen.
Recent studies showed that probiotic as immunomodulator
decreases inflammatory process induced by food allergy. No suf-
ficient clinical evidence reported about the efficacy of combination
sublingual immunotherapy and probiotics or probiotics only in
clinical improvement of childhood asthma.
Objective To investigate the role of SLIT and probiotic on clinical
parameters of childhood asthma (FEVl reversibility, medication
score, and symptom score).
Methods A randomized single blind clinical trial was conducted
on 6-17 year-old asthmatic children sensitive to food and aero-
allergens. Subjects were allocated to Group A receiving SLIT,
Group B receiving probiotics and SLIT, Group C receiving probiot-
ics only. All parameters were evaluated in week 0 untill4.
Results FEVl reversibility improved in all groups. Medication
score and symptom score was also decreased in all groups. The
most marked decrease of FEVl reversibility and symptom score
were found in probiotics group. Statistical analysis revealed
that the difference of each parameter between groups were not
Conclusion Combination of SLIT and probiotics and probiot-
ics are only similarly effective to improve clinical symptoms as
childhood asthma. Hence, information about probiotics as im-
munomodulator was proved to be an excellent alternative therapy
for childhood asthma has been obtained.

Article Details

How to Cite
lrmawati M, Endaryanto A, Harsono A. Role of sublingual immunotherapy and probiotics in clinical improvements of childhood asthma. PI [Internet]. 15Sep.2016 [cited 27Sep.2020];48(5):261-. Available from:
Author Biographies

Mira lrmawati

Department of Child Health, Medical School, Airlangga
University, Surabaya, Indonesia

Anang Endaryanto

Department of Child Health, Medical School, Airlangga
University, Surabaya, Indonesia

Arijanto Harsono

Department of Child Health, Medical School, Airlangga
University, Surabaya, Indonesia
Received 2016-09-11
Accepted 2016-09-11
Published 2016-09-15


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