Association between obesity and lipid profile in children 10--12 years of age
Keywords:
obesity, hypercholesterolemia, dyslipidemia, hypertriglyceridemia
Abstract
Background Worldwide prevalence of obesity in children hasbeen increasing. Together with dyslipidemia and hypertension,
obesity is associated with higher risk of cardiovascular morbidity
later in life.
Objective The aim of this study was to assess association
between obesity and occurrence of dyslipidemia in 10-12 years
old children.
Methods We performed a cross sectional study on 53 obese and
53 non-obese children matched for age and gender in Yogyakarta.
Obesity was defined as body mass index (BMI) at or above the
95th percentile of the CDC 2000 reference. The levels of total
cholesterol, LDL-cholesterol, HDL-cholesterol and triglyceride
were measured. Dyslipidemia was defined as increased level of
total cholesterol, LDL-cholesterol, triglyceride and decreased
level of HDL-cholesterol.
Results Obese children had higher risk of increased level of
triglyseride, i.e. RR 2.6 (95% CI 1.6 to 4.4), P<O.OOl and
decreased level ofHDL-cholesterol, i.e. RR 17.8 (95%CI 14.0 to
20.1), P=0.003. Overall, relative risk for dyslipidemia in obese
children was 5.2 (95%CI 4.2 to 5.9), P=0.002, higher than in
non-obese children.
Conclusion Compared to non-obese children, obese children have
higher risk of dyslipidemia, particularly hypertriglyceridemia and
hypo-HDL.
References
1. Slyper AH. Children obesity, adipose tissue, distributor and
the pediatric practitioner. Pediatric 1998;102:1-9.
2. Thresacovec AM, Jawad AF, Stouffer NO, Elkasabany A,
Srinivasan SR, Berenson GS. Persistent hypercholesterolemia
is associated with development of obesity among girls: The
Bogulosa Heart Study. Am J Clin Nutr 2002;76:730-5.
3. Freedman DS, Dietsz W, Srinivasan SR, Berenson GS.
The relation of Overweight to cardiovascular risk factor
among children and adolescent: The Bogalusa Heart Study.
Pediatrics 1999;103:1175-82
4. Crindle BM. Screening and management of children with
hyperlipidemia. Pediatric Annual 2000;29.
5. Muratova VN, Demerath EW, Spangler E, Ogershok P,
Elliot E, Minor VE. The relation of obesity to cardiovascular
risk factor among children:the CARDIAC project. NEJM
2002;98 Suppl 6:263-7.
6. Lambert M, Assauline L, Feoli-FonsecesaJC, Burn N, Delvin
EE, Levy E. Determinant of lipid level variability in French-
Canadian children with familial hypercholesterolemia.
Arteriocler Thromb Vase Biol2001;21:979-84.
7. Tee ES. Obesity in Asia: prevalence and issue in assessment
methodologies. Asia Pasific J Clin Nutr 2002;11 Suppl
3:S694-0l.
8. Winter W Pediatric lipid disorder in clinical practice 2004.
Available from URL: http://www.emedicine.com
9. Slyper, AH. Childhood obesity, adipose tissue, distributor and
the pediatric practitioner. Pediatric 1998;96: 102-12.
10. Goran MI, Gower BA. Relation between visceral fat and
disease risk in children and adolescent. AmJ Clin Nutr 1999;
70:149-56.
11. Grundy SM. Cholesterol and coronary hearth disease. JAMA
1998;28:2849-58.
12. Mahan LK, Arlin MT. Nutrition in hypertension. In: Mahan
LK, Arlin MT, editors. Krause's food, nutrition &diet therapy.
8th ed. Philadelphia: Saunders, 1992:387-94,569-78.
13. Tran ZV, Weltman. Different effect of exercise on serum lipid
and lipoprotein leel seen with changes is body weight. JAMA
1985;254:919-24.
14. Kim HM, Park J, Kim HS, Kim DH, Park SH. Obesity and
cardiovascular risk factor in Korea children and adolescent
aged 10-18 years from the Korean National Health and
nutritional examination survey, 1998 and 2001. Am J Epid
2006;64 Suppl 8:787-93.
15. Boyd GS, Koenigsberg J, Gidding S, Hassink S. Effect of
obesity and high blood pressure on plasma lipid level in
children and adolescents. Pediatrics 2005;166: 442-6.
16. Albisetti M, Chan A, McCrindel BW, Wong D, Monagle P,
Andrew M. Impairement fibrinolytic activity is present in
children with dyslipidemia. Pediatr Res 2004;55:576-80.
the pediatric practitioner. Pediatric 1998;102:1-9.
2. Thresacovec AM, Jawad AF, Stouffer NO, Elkasabany A,
Srinivasan SR, Berenson GS. Persistent hypercholesterolemia
is associated with development of obesity among girls: The
Bogulosa Heart Study. Am J Clin Nutr 2002;76:730-5.
3. Freedman DS, Dietsz W, Srinivasan SR, Berenson GS.
The relation of Overweight to cardiovascular risk factor
among children and adolescent: The Bogalusa Heart Study.
Pediatrics 1999;103:1175-82
4. Crindle BM. Screening and management of children with
hyperlipidemia. Pediatric Annual 2000;29.
5. Muratova VN, Demerath EW, Spangler E, Ogershok P,
Elliot E, Minor VE. The relation of obesity to cardiovascular
risk factor among children:the CARDIAC project. NEJM
2002;98 Suppl 6:263-7.
6. Lambert M, Assauline L, Feoli-FonsecesaJC, Burn N, Delvin
EE, Levy E. Determinant of lipid level variability in French-
Canadian children with familial hypercholesterolemia.
Arteriocler Thromb Vase Biol2001;21:979-84.
7. Tee ES. Obesity in Asia: prevalence and issue in assessment
methodologies. Asia Pasific J Clin Nutr 2002;11 Suppl
3:S694-0l.
8. Winter W Pediatric lipid disorder in clinical practice 2004.
Available from URL: http://www.emedicine.com
9. Slyper, AH. Childhood obesity, adipose tissue, distributor and
the pediatric practitioner. Pediatric 1998;96: 102-12.
10. Goran MI, Gower BA. Relation between visceral fat and
disease risk in children and adolescent. AmJ Clin Nutr 1999;
70:149-56.
11. Grundy SM. Cholesterol and coronary hearth disease. JAMA
1998;28:2849-58.
12. Mahan LK, Arlin MT. Nutrition in hypertension. In: Mahan
LK, Arlin MT, editors. Krause's food, nutrition &diet therapy.
8th ed. Philadelphia: Saunders, 1992:387-94,569-78.
13. Tran ZV, Weltman. Different effect of exercise on serum lipid
and lipoprotein leel seen with changes is body weight. JAMA
1985;254:919-24.
14. Kim HM, Park J, Kim HS, Kim DH, Park SH. Obesity and
cardiovascular risk factor in Korea children and adolescent
aged 10-18 years from the Korean National Health and
nutritional examination survey, 1998 and 2001. Am J Epid
2006;64 Suppl 8:787-93.
15. Boyd GS, Koenigsberg J, Gidding S, Hassink S. Effect of
obesity and high blood pressure on plasma lipid level in
children and adolescents. Pediatrics 2005;166: 442-6.
16. Albisetti M, Chan A, McCrindel BW, Wong D, Monagle P,
Andrew M. Impairement fibrinolytic activity is present in
children with dyslipidemia. Pediatr Res 2004;55:576-80.
Published
2016-09-15
How to Cite
1.
Himah R, Prawirohartono E, Julia M. Association between obesity and lipid profile in children 10--12 years of age. PI [Internet]. 15Sep.2016 [cited 25Apr.2024];48(5):257-0. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/592
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Received 2016-09-11
Accepted 2016-09-11
Published 2016-09-15
Accepted 2016-09-11
Published 2016-09-15
