Comparison of blood plasma and gelatin solution in resuscitation of children with dengue shock syndrome

Main Article Content

Suryadi Nicolaas Napoleon Tatura
Novie Homenta Rampengan
Jose Meky Mandei
Ari Lukas Runtunuwu
Max FJ Mantik
Tony Homenta Rampengan

Abstract

Background Dengue shock syndrome (DSS) is characterized by
severe vascular leakage and hemostasis disorder. It is the cause of death in 1 to 5 percent of cases. WH 0 management guidelines for resuscitation remain empirical rather than evidence-based.
Objective To find out the alternative fluids to replace plasma
leakage in DSS.
Methods We performed a prospective study and randomized
comparison of plasma and gelatin solution for resuscitation of
Indonesian children with DSS. We randomly assigned 25 subjects
with DSS to receive plasma and 25 children to receive gelatin
fluid. Statistical analyse were performed using chi-square test,
Fisher's exact test, t test, Mann-Whitney test.
Results The increment of pulse pressure width and the decrement of hematocrit in subjects treated with gelatin were higher than that of plasma atfour-hour therapy (P=0.002 and P=0.017). Only one patient died caused by unusually manifestation of DSS. The increment of body temperature in subjects treated with plasma was higher than that of gelatin at four-hour therapy (P=O.Oll). The decrement of platelet count in subjects treated with gelatin were less than that of plasma (P=0.018). The increment of diuresis rate in subjects treated with gelatin was higher than that of plasma at twenty-hour therapy (P<O.OOOl). The decrement of respiratory rate in subjects treated with gelatin was higher than that of plasma
at twenty-eight hour therapy (P=0.018). There was no difference
in studied variables : total volume rate, blood pressure, pulse rate, re-shock rate, clinical fluid overload, allergy reactions, bleeding manifestations, and length of stay (P>0.05).
Conclusions Gelatin solution can be used as volume replacement
in resuscitation of DSS if blood plasma is not available especially
at four-hour therapy.

Article Details

How to Cite
1.
Tatura S, Rampengan N, Mandei J, Runtunuwu A, Mantik M, Rampengan T. Comparison of blood plasma and gelatin solution in resuscitation of children with dengue shock syndrome. PI [Internet]. 31Dec.2009 [cited 18Nov.2019];49(6):322-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/591
Section
Articles
Author Biographies

Suryadi Nicolaas Napoleon Tatura

Child Health, Medical School, Sam Ratulangi
University, Manado, Indonesia.

Novie Homenta Rampengan

Child Health, Medical School, Sam Ratulangi
University, Manado, Indonesia.

Jose Meky Mandei

Child Health, Medical School, Sam Ratulangi
University, Manado, Indonesia.

Ari Lukas Runtunuwu

Child Health, Medical School, Sam Ratulangi
University, Manado, Indonesia.

Max FJ Mantik

Child Health, Medical School, Sam Ratulangi
University, Manado, Indonesia.

Tony Homenta Rampengan

Child Health, Medical School, Sam Ratulangi
University, Manado, Indonesia.
Received 2016-09-11
Accepted 2016-09-11
Published 2009-12-31

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