Effectiveness of cyproheptadine in the prevention of childhood migraine

Main Article Content

Zulkarnain Zulkarnain
Johannes Saing
Yazid Dimyati
Bistok Saing

Abstract

Background Migraine is one of the causes of recurrent headache
in childhood. Cyproheptadine is well known as an antihistamine,
but there are few studies revealing the drug's effect in pediatric
migraine.
Objective To determine the effectiveness of cyproheptadine in the prophylactic treatment of childhood migraine.
Methods A randomized placebo-controlled clinical trial study
was performed at Medan. One hundred children with migraine
according to the International Headache Society criteria were
included in the study. Subjects were divided into two groups, and
each group was given either 4 mg cyproheptadine or placebo for 12 weeks. Headache frequency was measured in headache days per month, duration was measured in hours and functional disability was measured by Pediatric Migraine Disability Assessment (PedMID AS). The efficacy was measured before intervention; also 1, 2, and 3 months after intervention.
Results A total of 100 patients, with age ranging from 11 to 18 years old (with mean, 15.5 years), were treated with cyproheptadine or placebo for headache. Compared to baseline, there was a significant difference on PedMIDAS grading of migraines in both groups (P<0.05). Headache frequency and duration per month were significantly different after treatment with cyproheptadine (P=0.009, 95% CI 0.001 to 0.030 and P= 0.029, 95% CI 0.690 to 27.510, RR=4.36), compared to placebo group (P> 0.05), but there were side effects of cyproheptadine up to 73%.
Conclusion Cyproheptadine appears to be effective as an
alternative prophylactic treatment of childhood migraine.
However, pediatricians should consider the significant side effects
of this drug.

Article Details

How to Cite
1.
Zulkarnain Z, Saing J, Dimyati Y, Saing B. Effectiveness of cyproheptadine in the prevention of childhood migraine. PI [Internet]. 31Oct.2009 [cited 19Jul.2019];49(5):286-1. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/585
Section
Articles
Author Biographies

Zulkarnain Zulkarnain

Department of Child Health, Medical School, University of
North Sumatera, Medan, Indonesia.

Johannes Saing

Department of Child Health, Medical School, University of
North Sumatera, Medan, Indonesia.

Yazid Dimyati

Department of Child Health, Medical School, University of
North Sumatera, Medan, Indonesia.

Bistok Saing

Department of Child Health, Medical School, University of
North Sumatera, Medan, Indonesia.
Received 2016-09-11
Accepted 2016-09-11
Published 2009-10-31

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