Comparison of the effect of oral multiple dose with single intramuscular vitamin K1 administration on prothrombin time in term baby

Main Article Content

Nancy Ervani
Bugis M. Lubis
Emil Azlin
Guslihan D. Tjipta
Lily Emsyah

Abstract

Background Vitamin K deficiency can cause bleeding disorders in
healthy breastfed infants. The efficacy of newborn intramuscular
vitamin K prophylaxis for the prevention of this bleeding problem
has been well established, but this is an invasive procedure. Oral
vitamin K prophylaxis is more effective, less expensive, and less
traumatic than intramuscular administration.
Objective To compare prothrombin time (PT) after the
administration of oral multiple dose vitamin K1 with that after
an intramuscular preparation.
Methods Infants were randomised at birth into the intramuscular
(IM) group (1 mg vitamin K1) and the oral group (2 mg given at
birth and repeated at day 3). PT was monitored before and after
the administration of vitamin K1.
Results Thirty six of 70 infants received oral vitamin K1. Mean
PT (SO) before vitamin K1 administration was 36.34 (SO 20.03)
seconds in oral group and 31.96 (SO 25.51) seconds in IM group, PT changes after vitamin K1 administration were 16.29 (SO 15.46) seconds in oral group and 11.58 (SO 10.62) seconds in IM group, it did not differ significantly (P=0.203).
Conclusion Prothrombin time changes are not significantly
different between oral vitamin K1 and IM group.

Article Details

How to Cite
1.
Ervani N, Lubis B, Azlin E, Tjipta G, Emsyah L. Comparison of the effect of oral multiple dose with single intramuscular vitamin K1 administration on prothrombin time in term baby. PI [Internet]. 31Oct.2009 [cited 27Nov.2020];49(5):281-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/584
Section
Articles
Author Biographies

Nancy Ervani

Department of Child Health, Medical School, University of
North Sumatera, H. Adam Malik Hospital, Medan, Indonesia

Bugis M. Lubis

Department of Child Health, Medical School, University of
North Sumatera, H. Adam Malik Hospital, Medan, Indonesia

Emil Azlin

Department of Child Health, Medical School, University of
North Sumatera, H. Adam Malik Hospital, Medan, Indonesia

Guslihan D. Tjipta

Department of Child Health, Medical School, University of
North Sumatera, H. Adam Malik Hospital, Medan, Indonesia

Lily Emsyah

Pirngadi Hospital, Medan , Indonesia
Received 2016-09-11
Accepted 2016-09-11
Published 2009-10-31

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