Growth velocity in elementary school children with iron deficiency anemia after iron therapy
Keywords:
body height, growth velocity, iron deficiency anemia
Abstract
Background Iron supplementation in children with iron deficiencyanemia could decrease the incidence of stunting.
Objective To study the effect of iron therapy on growth velocity
in children with iron deficiency anemia.
Methods A randomized clinical trial study was conducted at
Labuhan Batu on November 2006 to May 2007. Iron deficiency
anemia was diagnosed if there were anemia, with mean corpuscular hemoglobin concentration <31 %, red cell distribution width index > 220, and Mentzer index> 13. Elementary school children (6-12 year old) with iron deficiency anemia were randomly assigned either to iron therapy group (children were given 6 mg iron/kg/day) or to placebo group for 3 months.
Results Among 300 children recruited, there were 125 children,
who suffered from iron deficiency anemia. After one month of
iron therapy, means of hemoglobin concentration were 12.4 g/dl in iron group and 11.7 g/dl in placebo group. There was a significant increase of height in iron group (129.9 (SD 7.58) em vs. 132.2 (SD 7.23) em) and in placebo (130.8 (SD 8.78) em vs. 128.7 (SD 8. 79) em), However, no significant difference was found in the mean of growth velocity between placebo and iron groups (2.1 (SD 0.01) em vs. 2.0 (SD 0.9) em.
Conclusion There is a significant increase in height, but no
significant difference between both groups in growth velocity.
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control. In : Brook CGD, Hindmarsh PC, editors. Clinical
pediatric endocrinology. 4'h ed. London: Blackwell science,
2002; p. 95-103.
5. Batubara JRL. Perawakan pendek. In: Pardede N, Bakri A,
Aditiawati, Prambudi, Herman E, editors. Proceedings of
the first annual meeting of the Indonesian Pediatric Society.
Palembang: Indonesian Pediatric Society, 2001; p. 83-93.
6. Styne DM. Pediatric endocrinology. Philadelphia: Lippincott
Williams & Wilkins, 2004; p. 44-81.
7. Dallman PR. Nutritional anemia. In: Rudolph AM, Hoffman
JIE, Rudolph CD,. editors. Rudolphs pediatrics. 20'h ed.
Connecticut: Appleton & Lange, 1996; p. 1176-80.
8. Raspati H, Reniati L, Susanah S. Anemia defisiensi besi.
In: Permono B, Sutaryo, Ugrasena IDG, Windiastuti E,
Abdulsalam M, editors. Buku ajar hematologi onkologi anak.
Jakarta: Badan Penerbit IDAI, 2005; p. 30-43.
9. Lukens JN. Iron metabolism and iron deficiency. In: Miller
DR, Baehner RI, Miller LP, editors. Blood disease of infancy
and childhood. 7'h ed. St. Louis: Mosby, 1995; p. 193-219.
10. Pusponegoro HD. Tumbuh kembang otak, pengaruh
malnutrisi dan defisiensi besi. Jakarta: Medical School
University of Indonesia; 2004.
11. Angeles IT, Schultink WJ, Matulessi P, Gross R, Sastroamidjojo
S. Decreased rate of stunting among anemic Indonesian
preschool children through iron supplementation. Am J Clin
Nutr. 1993;58:339-42.
12. Chwang L. Soemantri AG, Pollitt E. Iron supplementation
and physical growth of rural Indonesian children. Am J Clin
Nutr. 1988;47:496-501.
13. Sungthong R, Mo-suwan L, Chongsuvivatwong V, Geater
AE Once weekly is superior to daily iron supplementation on
height gain, but not on hematological improvement among
school children in Thailand. J Nutr. 2002;132:418-22.
14. Dijkhuizen MA, Wieringa FT, West CE, Martuti S, Muhilal.
Effects of iron and zinc supplementation in Indonesian infants
on micronutrient status and growth. J Nutr. 2001;131: 2860-65
15. Oski FA. Iron deficiency in infancy and childhood. N Engl
J Med. 1993; 329: 190-3.
16. Harmatz P, Butensky E, Lubin B. Nutritional Anemias. In:
Walker WA, Watkins JB, Duggan C, editors. Nutrition in
Pediatrics. Basic science and clinical applications. Jrd ed.
London: BC Decker Inc, 2003; p.830-44
17. Abdulsalam M. Diagnosis, pengobatan dan pencegahan
anemia defisiensi besi pada bayi dan anak. In: Triasih R,
editors. Anemia defisiensi besi. MEDIKA: Medical school
Gadjah Mada University, 2005; p.55-64
18. Tridjaja B. Perawakan dan pertumbuhan. In: Pulungan AB,
editor. Makalah lengkap nutrition growth-development
continuing professional development IDAI Jaya 2006.
Jakarta: IDAI Jakarta, 2006; p.l0-8.
Published
2009-10-31
How to Cite
1.
Lyfia D, Deliana M, Hakimi H, Rosdiana N, Lubis B. Growth velocity in elementary school children with iron deficiency anemia after iron therapy. PI [Internet]. 31Oct.2009 [cited 24Nov.2024];49(5):249-2. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/578
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Received 2016-09-11
Accepted 2016-09-11
Published 2009-10-31
Accepted 2016-09-11
Published 2009-10-31
