Effect of probiotic on the fecal slgA level in preterm infants (A randomized double-blind placebo control study)

  • Lucia P Retnaningtyas
  • Subijanto M Sudarmo
  • Ariyanto Harsono
  • Sylviati M Damanik
Keywords: preterm infant, probiotic, fecal sIgA

Abstract

Background Secretory immunoglobulin A (slgA) plays an
important role in the defense of gastrointestinal tract. Preterm
infants that developed abnormal pattern of bowel colonization
may benefit from strategy to support maturation of humoral im-
munity and endogenous production of slgA by early colonization
with probiotic.
Objective To evaluate the effect of pro biotic on the fecal slgA
level in newborn preterm infants.
Methods A randomized control study of newborn pre term infants
was conducted in NICU Dr Soetomo Hospital, Surabaya in
November-December 2007. Pro biotic group was given multi-
strain pro biotic containing 107 cfu of Lactobacillus acidophil us,
Bifidobacterium longum, and Streptococcus faecium once daily
for 14 days from second day of life. Fecal slgA was determined by
ELISA before and after intervention. Subjects who got respiratory
distress syndrome (RDS) or sepsis during the study was dropped
out. Statistical analysis used in this study were chi-square, inde-
pendent sample t-test, Mann-Whitney, Wilcoxon Signed-Ranks
test, and multivariate analysis of variance (a=O.OS).
Results Forty seven neonates were enrolled, seven of them were
dropped out. Forty analyzed neonates were divided in probiotic
(n = 20) and placebo group (n = 20). The basic characteristics of
two groups were similar. At first examination, median of fecal slgA
level did not differ significantly between groups (P=0.512), 0.164
and 0.174mg/g feces in probiotic and placebo group respectively.
There was higher increment of fecal slgA level in pro biotic than
placebo group post treatment(1.735 versus 1.449 mg/g feces,
P=0.003).
Conclusion Preterm infants may benefit from probiotic because
of the clear tendency to increase fecal slgA secretion

Author Biographies

Lucia P Retnaningtyas
Department of Child Health, Division of Gastroenterology,
Medical School, Airlangga University, Soetomo Hospital, Surabaya.
Subijanto M Sudarmo
Department of Child Health, Division of Gastroenterology,
Medical School, Airlangga University, Soetomo Hospital, Surabaya.
Ariyanto Harsono
Department of Child Health, Division of Gastroenterology,
Medical School, Airlangga University, Soetomo Hospital, Surabaya.
Sylviati M Damanik
Department of Child Health, Division of Gastroenterology,
Medical School, Airlangga University, Soetomo Hospital, Surabaya.

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Published
2008-08-31
How to Cite
1.
Retnaningtyas L, Sudarmo S, Harsono A, Damanik S. Effect of probiotic on the fecal slgA level in preterm infants (A randomized double-blind placebo control study). PI [Internet]. 31Aug.2008 [cited 28Mar.2024];48(4):246-2. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/576
Section
Articles
Received 2016-09-10
Accepted 2016-09-10
Published 2008-08-31