Parascreen as an alternative diagnostic tool for falciparum malaria
Keywords:
malaria, Plasmodium falciparum, Parascreen, sensitivity, specificity
Abstract
Background Malaria is a parasitic disease with high morbidityand mortality. Rapid immunochromatographic are emerging to
detect specific antigens of human plasmodia.
Objective To determine the sensitivity and specificity ofParascreen
for the detection of Plasmodium falciparum in children.
Methods A diagnostic test study was performed in Mandailing
Natal District, Penyabungan, North Sumatera. Subjects were
public health center and hospital patients with symptoms of fever,
pallor, headache, and diarrhea. Blood specimens were obtained for
Parascreen testing. Microscopy of Giemsa-stained blood samples
served as the gold standard.
Results One hundred and four subjects were studied. The sensitiv-
ity and specificity ofParascreen were 76% and 100%, respectively.
Positive and negative predictive values of the test were 100% and
49%, respectively. Likelihood ratio was infinite for a positive test
and 0.23% for a negative test.
Conclusion Parascreen is a useful and highly specific di-
agnostic tool for P. falciparum malaria
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of asymptomatic malaria in a Plasmodium falciparum/vivax
endemic area in Thailand. Am J Trop Med Hyg 2002;66
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tors. Krugman's infectious diseases of children. 11th edition.
Philadelphia: Mosby; 2004. p. 33 7-48.
2. Harianto PN. Manifestasi klinik, komplikasi dan diagnosis
malaria. Medika 1993;9:31-8.
3. Gorbach SL, Falagas M. Malaria. In: Gorbach SL, Falagas M,
editors. The 5-minute infectious diseases consult. Philadel-
phia: Lippincott Williams & Wilkins; 2001. p. 258-9.
4. Aslan G, Ulukanligil M, Seyrek A, Erel O. Diagnostic perfor-
mance characteristics of rapid dipstick test for plasmodium
vivax malaria. Mem Inst Oswaldo Cruz 2001;96 Suppl
5:683-6.
5. Krause PJ. Malaria (plasmodium). In: Behrman RE, Kliegman
RM, Jenson HB, editors. Nelson textbook of pediatrics. 17th
edition. Philadelphia: Saunders; 2004. p. 1139-43.
6. Diallo AB, Serres GD, Beavogui AH, Lapointe C, Viens P.
Home care of malaria-infected children of less than 5 years
of age in a rural area of the Republic of Guinea. Bull WHO
2001;79:28-32.
7. Krogstad DJ. Plasmodium species (malaria). In: Mandell
GL, Bennet JE, Dolin R, editors. Principles and practice
of infectious diseases. 5th edition. Philadelphia: Churchill
Livingstone; 2000. p. 2817-31.
8. Taylor TE, Strickland GT. Malaria. In: Strickland GT, editor.
Hunter's tropical medicine and emerging infectious diseases.
8th edition. Philadelphia: WB Saunders; 2000. p. 614-43.
9. Siregar M. Epidemiologi malaria. In: Proceedings of the
Symposium on Recent Advances in Malaria; 1994 Dec 6;
Medan, Indonesia. p. 1-11.
10. Mya MM, Saxena RK. Evaluation of developed Plasmodium
falciparum malaria diagnostic technique. IE(I) Journal-ID
2004;85:58-62.
11. Richardson DC, Ciach M, Zhong KJY, Crandall I, Kain
KC. Evaluation of the Macromed dipstick assay versus PCR
for diagnosis of plasmodium falciparum malaria in returned
travelers. J Clin Microbiol2002;40:4528-30.
12. Moody A. Rapid diagnostic tests for malaria parasites. Clin
Micro bioi Rev 2002; 15:66-78.
13. Shujatullah F, Malik A, Khan HM, Malik A. Comparison of
different diagnostic techniques in Plasmodium falciparum
cerebral malaria. J Vect Borne 2006;43: 186-90.
14. Khan SA, Anwar M, Hussain S, Qureshi AH, Ahmad M,
Afzal AS. Comparison of optimal malarial test with light
microscopy for the diagnosis of malaria. J Pak Med Assoc
2004;54:404.
15. Arai M, Ishii A, Matsuoka H. Laboratory evaluation of the
ICT malaria Pf/Pv immunochromatographic test for detecting
the panmalarial antigen using rodent malaria model. Am J
Trop Med Hyg 2004;70 Suppl2:139-43.
16. Tjitra E, Suprianto S, Dyer M, Currie BJ, Anstey NM. Field
evaluation of the ICT malaria Pf/Pv immunochromato-
graphic test for detection of Plasmodium falciparum and
Plasmodium vivax in patients with a presumptive clinical
diagnosis of malaria in Eastern Indonesia. J Clin Microbiol
1999;37:2412-7.
17. Palmer CJ, Lindo JF, Klaskala WI, Quesada JA, Kaminsky
R, Baum MK, et al. Evaluation of the optimal test for rapid
diagnosis of Plasmodium vivax and Plasmodium falciparum
malaria. J Clin Microbiol1998;36:203-6.
18. Richter J, Harms G, Muller-Stover I, Gobels K, Haussinger
D. Performance of an immunochromatographic test for the
rapid diagnosis of malaria. Parasitol Res 2004;92:518-9.
19. Pusponegoro HD, Wirya ION, Pudjiadi AH, Bisanto J, Zulkar-
nain SZ. Uji diagnostik. Dalam: Sastroasmoro S, Ismael S,
editors. Dasar-dasar metodologi penelitian klinis. 2nd Edi-
tion. Jakarta: CV Sagung Seto; 2002. p. 166-85.
20. Marietta R, Harijani AM, Sustriayu N, Sekartuti, Tjitra E.
Penelitian malaria di Kecamatan Teluk Dalam, Nias, Sumat-
era Utara. Cermin Dunia Kedokteran 1996;106:5-9.
21. Arum I, Purwanto AP, Arfi S, Tetrawindu H, Octora M,
Mulyanto, et al. Uji diagnostik Plasmodium malariae menggu-
nakan metode imunokromatografi diperbandingkan dengan
pemeriksaan mikroskopis. J Clin Pathol 2006;3: 118-22.
22. Kakkilaya BS. Rapid diagnosis of malaria. Lab Medicine
2003;8:602-8.
23. Singh N, Saxena A, Valecha N. Field evaluation of the ICT
malaria Pf/Pv immunochromatographic test for diagnosis of
Plasmodium falciparum and Plasmodium vivax infection in
forest villages of Chhindawara, Central India. Trop Med Int
Health 2008;5:765-70.
24. Desrinawati. Perbandingan hasil pemeriksaan metoda im-
munochromatographic test (ICT) dengan pewarnaan Giemsa
pada infeksi malaria falsiparum. Sari Pediatri 2002;4 Suppl
3:1-13.
25. Jelinek T, Grobusch MP, Schwenke S, Steidl S, Sonneburg
FV, Nothdurft HD, eta!. Sensitivity and specificity of dipstick
test for rapid diagnosis of malaria in nonimmune travelers. J
Clin Microbiol1999;37:721-3.
26. Coleman RE, Maneechai N, Rachapaew N, Kumpitak C,
Soyseng V, Miller RS, eta!. Field evaluation of the ICT ma-
laria Pf/Pv immunochromatographic test for the detection
of asymptomatic malaria in a Plasmodium falciparum/vivax
endemic area in Thailand. Am J Trop Med Hyg 2002;66
Suppl4:379-83.
Published
2008-08-31
How to Cite
1.
Ginting J, Mayasari S, Lubis M, Pasaribu S, Lubis C. Parascreen as an alternative diagnostic tool for falciparum malaria. PI [Internet]. 31Aug.2008 [cited 23Nov.2024];48(4):220-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/571
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Received 2016-09-10
Accepted 2016-09-10
Published 2008-08-31
Accepted 2016-09-10
Published 2008-08-31
