Serological profile and hemolytic disease in term neonates with ABO incompatibility

Main Article Content

Desiana Dharmayani
Djajadiman Gatot
Rinawati Rohsiswatmo
Bambang Tridjaja

Abstract

Background Hemolytic disease of the newborn (HDN) due to
ABO blood type incompatibility is one of the most common
cause of neonatal hyperbilirubunemia that potentially leads to
bilirubin encephalopathy. Data on ABO-hemolytic disease of the
newborn (ABO-HDN), especially regarding umbilical cord blood
serological profile, are limited.
Objective To identify the serological profile and hemolytic disease in term neonates with ABO incompatibility.
Methods This was a cross-sectional descriptive study, conducted
at RSIA Budi Kemuliaan Jakarta.
Results We found 68 healthy term neonates with ABO
incompatibility, nine of them had positive direct antiglobulin
test (OAT) result, and 38 subjects had a positive result on
OAT with elution method. The highest titer of IgG was 1:8.
Hyperbilirubinemia was found in 30 ( 44%) subjects, and
ABO-HDN was diagnosed in 28 (41 %) subjects. Within the
positive OAT group, eight out of nine subjects had suffered
from hyperbilirubinemia and ABO-HDN. Meanwhile, within
the positive OAT with elution method group; 24 subjects had
suffered from hyperbilirubinemia with 23 of them having ABOHDN. Based on the chi-square analysis; those with positive OAT with elution method had 3.2 times higher risk of suffering from ABO-HDN. Furthermore, there was a 3.6 times higher risk of
sufferring from hyperbilirubinemia.
Conclusion In healthy term neonates with ABO incompatibility,
the incidence of ABO-HDN is 41%. OAT serological examination
with elution method is better than OAT in assessing risk
for hyperbilirubinemia and ABO-HDN.

Article Details

How to Cite
1.
Dharmayani D, Gatot D, Rohsiswatmo R, Tridjaja B. Serological profile and hemolytic disease in term neonates with ABO incompatibility. PI [Internet]. 31Aug.2009 [cited 16Sep.2019];49(4):219-3. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/560
Section
Articles
Author Biographies

Desiana Dharmayani

Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Djajadiman Gatot

Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Rinawati Rohsiswatmo

Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Bambang Tridjaja

Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Received 2016-09-10
Accepted 2016-09-10
Published 2009-08-31

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