Magnesium intake and insulin resistance in obese adolescent girls
Keywords:
magnesium intake, insulin resistance, obesity, female, adolescent
Abstract
Background The worldwide increase in the prevalence ofcardiovascular diseases in adulthood is related to obesity in
children and adolescents. Insulin resistance and hyperinsulinemia observed in obese individuals are the precursors of cardiovascular diseases and type 2 diabetes mellitus. Magnesium, through its action on insulin receptors, is proposed to be an important factor in preventing insulin resistance.
Objective The aim of this study was to assess the association
between magnesium intake and insulin resistance in obese
adolescent girls.
Methods This was a cross-sectional study on obese adolescent
girls in Yogyakarta, Indonesia. Insulin resistance was defined as a HOMA-IR index of3.16 or more. HOMA-IR was calculated using
fasting insulin and plasma glucose levels. Magnesium intake and
energy adjusted magnesium intake were measured using a 24-hour food recall method on 6 non-consecutive days.
Results Of 7 8 obese adolescent girls included in our study, 56% of them were found to be insulin resistant. Magnesium intake was only 61 o/o of the recommended daily requirement for adolescent girls. There were no significant associations between magnesium intake and either HOMA-IR or hyperinsulinemia.
Conclusion Our study does not find an association between
insulin resistance and magnesium intake in obese adolescent girls.
References
1. Steinberger J, Moran A, Hong CP, Jacobs DR,Jr., Sinaiko AR.
Adiposity in childhood predicts obesity and insulin resistance
in young adulthood. J Pediatr. 2001; 138:469-73.
2. Sinaiko AR, Donahue RP, Jacobs DR Jr., Prineas RJ. Relation
of weight and rate of increase in weight during childhood and
adolescence to body size, blood pressure, fasting insulin, and
lipids in young adults: The Minneapolis Children's Blood
Pressure Study. Circulation. 1999;99:1471-6.
3. Lee JM, Okumura MJ, Davis MM, Herman WH, Gurney JG.
Prevalence and determinants of insulin resistance among U.S.
adolescents. Diabetes Care. 2006;29:2427-32.
4. Julia M, van Weissenbruch MM, Prawirohartono EP, Surjono
A, Delemarre-van de Waal HA. Tracking for underweight,
overweight and obesity from childhood to adolescence:
a 5-year follow-up study in urban Indonesian children.
Hormone Research. 2008;69:301-6.
5. Fung TT, Manson JE, Solomon CG, Liu S, Willett WC, Hu
BFB. The association between magnesium intake and fasting
insulin concentration in healthy middle-aged women. Journal
of American College of Nutrition. 2003;22:533-8.
6. Song W, Manson JE, Buring JE, Liu S. Dietary magnesium
intake in relation to plasma insulin levels and risk of type 2
diabetes in women. Diabetes Care. 2004;27:59-64.
7. Moran MR, Romero FG. Oral magnesium supplementations
improve insulin sensitivity and metabolic control in type 2
diabetic subject - a randomized double-blind control trial.
Diabetes Care. 2003;26:1147-52.
8. Suarez A, Pulido N, Casla A, Casanova B, Arrieta FJ, Rovira
A. Impaired tyrosine-kinase activity of muscle insulin
receptors from hypomagnesaemic rats. Diabetologia. 1995;
38:1262-70.
9. Balon TW, J as man A, ScottS, Meehan WP, Rude RK, Nadler
JL. Dietary magnesium prevents fructose-induced insulin
sensitivity in rats. Hypertension. 1994;23: 1036-9.
10. Nadler JL, Buchanan T, Natarajan R, Antonipillai I, Bergman
R, Rude R. Magnesium deficiency produces insulin resistance
and increased thromboxane synthesis. Hypertension.
1993;21: 1024-9.
11. Paolisso G, Scheen A, D'Onofrio F, Lefebvre P. Magnesium
and glucose homeostasis. Diabetologia. 1990;33:511-4.
12. Dzurik R, Stefikova K, Spustova V, Fetkovska N. The role of
magnesium deficiency in insulin resistance. An in vitro study.
J Hypertension. 1991;9: S312-3.
13. Huerta MG, Roemmich JN, Kington ML, Bovbjerg VE,
Weltman AL, Holmes VF, Patrie JT, Rogol AD, Nadler JL.
Magnesium deficiency is associated with insulin resistance
in obese children. Diabetes Care. 2005;28: 1175-81.
14. Klein-Platat C, Drai J, Oujaa M, Schlienger JL, Simon C.
Plasma fatty acid composition is associated with the metabolic
syndrome and low-grade inflammation in overweight
adolescents. Am J Clin Nutr. 2005;82: 1178-84.
15. Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM,
Flegal KM, Mei Z, Wei R, Curtin LR, Roche AF, Johnson
CL. CDC growth charts for the United States: methods and
development. National Center for Health Statistics. Vital
Health Stat. 2000; 11:246.
16. Keskin M, Kurtoglu S, Kendirsi, Atabek E, Yazici C.
Homoeostasis Model Assessment is more reliable than
the fasting glucose/insulin ratio and quantitative insulin
sensitivity check index for assessing insulin resistance
among obese Children and Adolescents. Pediatrics.
2005; 115:e500-3.
17. Beaton GH, Milner J, McGuire V, Feather TE, Little JA.
Source of variance in 24-hour recall data: implications for
nutrition study design and interpretation. Am J Clin Nutr.
1979;37:985- 95.
18. Hammond KA. Dietary and clinical assessment. In: Mahan
LK, Escott-StumpS, editors. Krause's food, nutrition, & diet
therapy. Philadelphia: Saunders, 2000; p.426.
19. Fine KD, Ana CAS, Fordtran JS. Diagnosis of magnesiuminduced
diarrhea. N Eng! J Med. 1991;324:1012-7.
20. Brink EJ, BeynenAC. Nutrition and Magnesium absorption:
a review. Prog Food Nutr Sci. 1992; 16:125-62.
21. Shils ME. Magnesium. In: Shils ME, Olson JA, Shike M,
Ross AC, editors. Modern nutrition in health and disease.
9th Edition. Maryland: Lippincott Williams & Wilkins, 1999;
p. 169.
22. Tongyai S, Rayssiguier Y, Motta C, Gueux E, Maurois P,
Heaton FW Mechanism of increased erythrocyte membrane
fluidity during magnesium deficiency in weanling rats. Am J
Physiol. 1989;257:C270-6.
23. Rosell MS, Hellenius MB, de Faire UH, Johansson GK.
Associations between diet and the metabolic syndrome vary
with the validity of dietary intake data. Am J Clin Nutr.
2003;78:84-90.
Adiposity in childhood predicts obesity and insulin resistance
in young adulthood. J Pediatr. 2001; 138:469-73.
2. Sinaiko AR, Donahue RP, Jacobs DR Jr., Prineas RJ. Relation
of weight and rate of increase in weight during childhood and
adolescence to body size, blood pressure, fasting insulin, and
lipids in young adults: The Minneapolis Children's Blood
Pressure Study. Circulation. 1999;99:1471-6.
3. Lee JM, Okumura MJ, Davis MM, Herman WH, Gurney JG.
Prevalence and determinants of insulin resistance among U.S.
adolescents. Diabetes Care. 2006;29:2427-32.
4. Julia M, van Weissenbruch MM, Prawirohartono EP, Surjono
A, Delemarre-van de Waal HA. Tracking for underweight,
overweight and obesity from childhood to adolescence:
a 5-year follow-up study in urban Indonesian children.
Hormone Research. 2008;69:301-6.
5. Fung TT, Manson JE, Solomon CG, Liu S, Willett WC, Hu
BFB. The association between magnesium intake and fasting
insulin concentration in healthy middle-aged women. Journal
of American College of Nutrition. 2003;22:533-8.
6. Song W, Manson JE, Buring JE, Liu S. Dietary magnesium
intake in relation to plasma insulin levels and risk of type 2
diabetes in women. Diabetes Care. 2004;27:59-64.
7. Moran MR, Romero FG. Oral magnesium supplementations
improve insulin sensitivity and metabolic control in type 2
diabetic subject - a randomized double-blind control trial.
Diabetes Care. 2003;26:1147-52.
8. Suarez A, Pulido N, Casla A, Casanova B, Arrieta FJ, Rovira
A. Impaired tyrosine-kinase activity of muscle insulin
receptors from hypomagnesaemic rats. Diabetologia. 1995;
38:1262-70.
9. Balon TW, J as man A, ScottS, Meehan WP, Rude RK, Nadler
JL. Dietary magnesium prevents fructose-induced insulin
sensitivity in rats. Hypertension. 1994;23: 1036-9.
10. Nadler JL, Buchanan T, Natarajan R, Antonipillai I, Bergman
R, Rude R. Magnesium deficiency produces insulin resistance
and increased thromboxane synthesis. Hypertension.
1993;21: 1024-9.
11. Paolisso G, Scheen A, D'Onofrio F, Lefebvre P. Magnesium
and glucose homeostasis. Diabetologia. 1990;33:511-4.
12. Dzurik R, Stefikova K, Spustova V, Fetkovska N. The role of
magnesium deficiency in insulin resistance. An in vitro study.
J Hypertension. 1991;9: S312-3.
13. Huerta MG, Roemmich JN, Kington ML, Bovbjerg VE,
Weltman AL, Holmes VF, Patrie JT, Rogol AD, Nadler JL.
Magnesium deficiency is associated with insulin resistance
in obese children. Diabetes Care. 2005;28: 1175-81.
14. Klein-Platat C, Drai J, Oujaa M, Schlienger JL, Simon C.
Plasma fatty acid composition is associated with the metabolic
syndrome and low-grade inflammation in overweight
adolescents. Am J Clin Nutr. 2005;82: 1178-84.
15. Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM,
Flegal KM, Mei Z, Wei R, Curtin LR, Roche AF, Johnson
CL. CDC growth charts for the United States: methods and
development. National Center for Health Statistics. Vital
Health Stat. 2000; 11:246.
16. Keskin M, Kurtoglu S, Kendirsi, Atabek E, Yazici C.
Homoeostasis Model Assessment is more reliable than
the fasting glucose/insulin ratio and quantitative insulin
sensitivity check index for assessing insulin resistance
among obese Children and Adolescents. Pediatrics.
2005; 115:e500-3.
17. Beaton GH, Milner J, McGuire V, Feather TE, Little JA.
Source of variance in 24-hour recall data: implications for
nutrition study design and interpretation. Am J Clin Nutr.
1979;37:985- 95.
18. Hammond KA. Dietary and clinical assessment. In: Mahan
LK, Escott-StumpS, editors. Krause's food, nutrition, & diet
therapy. Philadelphia: Saunders, 2000; p.426.
19. Fine KD, Ana CAS, Fordtran JS. Diagnosis of magnesiuminduced
diarrhea. N Eng! J Med. 1991;324:1012-7.
20. Brink EJ, BeynenAC. Nutrition and Magnesium absorption:
a review. Prog Food Nutr Sci. 1992; 16:125-62.
21. Shils ME. Magnesium. In: Shils ME, Olson JA, Shike M,
Ross AC, editors. Modern nutrition in health and disease.
9th Edition. Maryland: Lippincott Williams & Wilkins, 1999;
p. 169.
22. Tongyai S, Rayssiguier Y, Motta C, Gueux E, Maurois P,
Heaton FW Mechanism of increased erythrocyte membrane
fluidity during magnesium deficiency in weanling rats. Am J
Physiol. 1989;257:C270-6.
23. Rosell MS, Hellenius MB, de Faire UH, Johansson GK.
Associations between diet and the metabolic syndrome vary
with the validity of dietary intake data. Am J Clin Nutr.
2003;78:84-90.
Published
2009-08-31
How to Cite
1.
Muhammad H, Huriyati E, Susilowati R, Julia M. Magnesium intake and insulin resistance in obese adolescent girls. PI [Internet]. 31Aug.2009 [cited 25Apr.2024];49(4):200-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/553
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Received 2016-09-10
Accepted 2016-09-10
Published 2009-08-31
Accepted 2016-09-10
Published 2009-08-31
