Effect of iron treatment on nutritional status of children with iron deficiency anemia
Keywords:
nutritional status, iron deficiency anemia, anthropometric
Abstract
Background Iron has been shown to improve growth in childrenwith iron deficiency anemia (IDA), as indicted by increases in
height and weight. Frequently, malnutrition and iron deficiency
coexist.
Objective To determine the effect of iron treatment on nutritional
status in children with IDA.
Methods A randomized placebo-controlled clinical trial was
conducted at Bilah Hulu, a subdistrict of Labuhan Batu, North
Sumatera, Indonesia, between November 2006 and February
2007. Iron deficiency anemia was diagnosed if there anemia
was present along with MCHC <31%, RDW index >220 and
Mentzer index> 13. Elementary school children (8-12 years old)
with IDA were randomly assigned to either receive a daily therapy
of 6 mg iron/kg/day or a placebo for three months. Nutritional
status was evaluated by anthropometric assessment before and
after intervention.
Results From 300 subjects recruited, there were 111 (3 7 .2%)
with iron deficiency anemia; 108 of them completed the therapy.
After intervention, the iron and placebo groups had different
mean hemoglobin concentrations (P <0.05), but there was no
significant difference in mean weight and height gain between
the two groups.
Conclusion A significant increase in hemoglobin concentration
was seen when iron was given, but did not affect weight and height increase in the subjects.
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C, editors. Nutrition in pediatrics. Basic science and clinical
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Walker WA, Watkins JB, Duggan C, editors. Nutrition in
pediatrics. Basic science and clinical applications. Jrd ed.
London: BC Decker Inc, 2003; p. 830-44.
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RM, Arvin AM, editors. Nelson textbook of pediatrics. 17'h
ed. Philadelphia: Saunders, 2004; p. 1614-6.
4. Abdulsalam M. Diagnosis, pengobatan dan pencegahan
anemia defisiensi besi pada bayi dan anak. In: Triasih R, editor.
Anemia defisiensi besi. Yogyakarta: Medika FK-UGM, 2005;
p. 55-64.
5. Soemantri A. Epidemiology of iron deficiency anaemia.
In : Triasih R, editor. Anemia defisiensi besi. Yogyakarta:
Medika-FK UGM, 2005; p. 11.
6. Chwang LC, Soemantri AG, Pollitt E. Iron supplementation
and physical growth of rural Indonesian children. Am J Clin
Nutr. 1998;47:496-501.
7. Sungthong R, Mo-suwan L, Chongsuvivatwong V, Geater
AF. Once weekly is superior to daily iron supplementation
on height gain, but not onhematological improvement
among school children in Thailand. J Nutr. 2002; 132:418-
22.
8. Dijkhuizen MA, Wieringa FT, West CE, Martuti S, Muhilal.
Effects of iron and zinc supplementation in Indonesian
infants on micronutrient status and growth. J N utr.
2001; 131:2860-5.
9. World Health Organization. Measuring change in nutritional
status. Guidelines for assesing the nutritional impact of
supplementary feeding programmes for vulnerable groups.
Geneva: WHO, 1983; p. 99-101.
10. Raspati H, Reniarti L, Susanah S. Anemia defisiensi besi.
In: Permono B, Sutaryo, Ugrasena IDG, Windiastuti E,
Abdulsalam M, editors. Buku ajar hematologi- onkologi anak.
Jakarta: BP IDAI, 2005; p. 30-43.
11. Hadi H. Be ban ganda masalah gizi dan implikasinya terhadap
kebijakan pembangunan kesehatan nasional. Proceeding of
the Pidato Pengukuhan Jabatan Guru Besar; 2005 February
5; Medical school Gadjah Mada University, Yogyakarta.
Yogyakarta: Gadjah Mada University; 2005.
Published
2009-07-01
How to Cite
1.
Agustian L, Sembiring T, Ariani A, Lubis B. Effect of iron treatment on nutritional status of children with iron deficiency anemia. PI [Internet]. 1Jul.2009 [cited 22Nov.2024];49(3):160-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/545
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Received 2016-09-10
Accepted 2016-09-10
Published 2009-07-01
Accepted 2016-09-10
Published 2009-07-01
