Effect of iron ... zinc fortified milk on iron status and functional outcomes in underweight children
Abstract
Background Iron and zinc are essential micronutrients duringschool-age period. Milk could be an alternative medium for
mineral fortification because it is consumed frequently by
children.
Objective To evaluate the effect of iron-zinc fortified milk
supplementation on iron status and functional outcomes in
underweight children.
Methods 44 2 underweight subjects aged 7-10 years attending 10
primary schools in Jakarta and Solo were recruited in the study.
Subjects who had chronic illnesses, severe anemia, thalassemia
or cow's milk allergy were excluded. Blood samples were analyzed
to determine hemoglobin, serum ferritin and serum zinc. Serum
CRP was measured in sub sampled subjects (n= 60). Subjects
were randomizedly allocated to receive iron-zinc fortified milk
(n = 225) and standard milk (n = 217) for six months. The fortified
milk will provide additional6.3 mg iron and 1.5 mg zinc per day (2
feeds). The main outcomes measured were iron status, cognitive
function, growth, physical fitness and morbidity.
Results Study groups were comparable at baseline. The fortified
milk group had better physical fitness score and exercise duration
at baseline. Both milk supplementations reduced the prevalence
of anemia and iron deficiency. Fortified milk improved the speed
processing score (P< 0.0001), height (P<0.0001) and sitting
height (P=O.Ol) significantly.
Conclusion Supplementation of milk reduces the prevalence of
anemia and iron deficiency. Zinc-iron fortified milk gives positive
impact on cognitive performance, growth, and physical fitness.
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Accepted 2016-09-10
Published 2009-07-01