Comparison of minimal inhibitory and bactericidal capacity of oral penicillin V with benzathine penicillin G to Streptococcus beta--hemolyticus group A in children with rheumatic heart disease

  • Burhanuddin Iskandar
  • Bambang Madiyono
  • Sudigdo Sastroasmoro
  • Sukman T. Putra
  • Mulyadi M. Djer
  • Anis Karuniawati
DOI: https://doi.org/10.14238/pi48.3.2008.152-5
Keywords: bactericidal, oral penicillin V and benzathine penicillin G, Streptococcus beta- hemolyticus group A

Abstract

Background Injection ofbenzatine penicillin G (BPG) every 28
days is still the drug of choice for secondary prevention of rheu-
matic heart disease (RHD). BPG sometimes poses problems due
to pain at the injection site, possible anaphylaxis, and is not always
available. Some centers choose oral penicillin over BPG.
Objectives To compare minimal inhibitory capacity (MIC) and
minimal bactericidal capacity (MBC) of oral penicillin V serum
with those of BPG among SGA infected RHD.
Methods This was a clinical trial with crossover design study to
compare MIC of penicillin V and BPG. Outcome measures were
MIC and MBC. Statistical analysis was performed using paired
t-test and wilcoxon test.
Result There were 32 subjects consisted of 17 males and 15
females. The mean value of MIC and MBC serum of penicillin
V were 0.031 and 0.125. The mean value of MIC and MBC
serum of BPG3 were 0.094 and 0.031. Respectively the MIC
of penicillin V was similar to that of BPGy The mean value of
MIC and MBC of BPG4 were 0.125 and 0.250. Respectively the
MIC of penicillin V was significantly higher than that of BPG 4.
The MBC of penicillin V was significantly higher than that of
BPG 4. The MIC ofBPG 3 was similar to that ofBPG 4• The MBC
of BPG 3 was similar to that of BPG 4.
Conclusions The MIC of penicillin V was similar to that ofBPG 3,
the MBC of oral penicillin V was higher than that ofBPG 3• The
MIC and MBC of penicillin V was higher than those of BPG 4.

Author Biographies

Burhanuddin Iskandar
Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia
Bambang Madiyono
Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia
Sudigdo Sastroasmoro
Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia
Sukman T. Putra
Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia
Mulyadi M. Djer
Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia
Anis Karuniawati
Department of Microbiology and Community, Medical School, University of lndonesia, Jakarta, Indonesia

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Published
2016-09-26
How to Cite
1.
Iskandar B, Madiyono B, Sastroasmoro S, Putra S, Djer M, Karuniawati A. Comparison of minimal inhibitory and bactericidal capacity of oral penicillin V with benzathine penicillin G to Streptococcus beta--hemolyticus group A in children with rheumatic heart disease. PI [Internet]. 26Sep.2016 [cited 6Nov.2024];48(3):152-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/523
Issue
Vol 48 No 3 (2008): May 2008
Section
Articles

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Received 2016-09-09
Accepted 2016-09-09
Published 2016-09-26