Comparison of minimal inhibitory and bactericidal capacity of oral penicillin V with benzathine penicillin G to Streptococcus beta--hemolyticus group A in children with rheumatic heart disease

  • Burhanuddin Iskandar
  • Bambang Madiyono
  • Sudigdo Sastroasmoro
  • Sukman T. Putra
  • Mulyadi M. Djer
  • Anis Karuniawati
DOI: https://doi.org/10.14238/pi48.3.2008.152-5
Keywords: bactericidal, oral penicillin V and benzathine penicillin G, Streptococcus beta- hemolyticus group A

Abstract

Background Injection ofbenzatine penicillin G (BPG) every 28
days is still the drug of choice for secondary prevention of rheu-
matic heart disease (RHD). BPG sometimes poses problems due
to pain at the injection site, possible anaphylaxis, and is not always
available. Some centers choose oral penicillin over BPG.
Objectives To compare minimal inhibitory capacity (MIC) and
minimal bactericidal capacity (MBC) of oral penicillin V serum
with those of BPG among SGA infected RHD.
Methods This was a clinical trial with crossover design study to
compare MIC of penicillin V and BPG. Outcome measures were
MIC and MBC. Statistical analysis was performed using paired
t-test and wilcoxon test.
Result There were 32 subjects consisted of 17 males and 15
females. The mean value of MIC and MBC serum of penicillin
V were 0.031 and 0.125. The mean value of MIC and MBC
serum of BPG3 were 0.094 and 0.031. Respectively the MIC
of penicillin V was similar to that of BPGy The mean value of
MIC and MBC of BPG4 were 0.125 and 0.250. Respectively the
MIC of penicillin V was significantly higher than that of BPG 4.
The MBC of penicillin V was significantly higher than that of
BPG 4. The MIC ofBPG 3 was similar to that ofBPG 4• The MBC
of BPG 3 was similar to that of BPG 4.
Conclusions The MIC of penicillin V was similar to that ofBPG 3,
the MBC of oral penicillin V was higher than that ofBPG 3• The
MIC and MBC of penicillin V was higher than those of BPG 4.

Author Biographies

Burhanuddin Iskandar
Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia
Bambang Madiyono
Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia
Sudigdo Sastroasmoro
Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia
Sukman T. Putra
Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia
Mulyadi M. Djer
Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia
Anis Karuniawati
Department of Microbiology and Community, Medical School, University of lndonesia, Jakarta, Indonesia

References

1. McLaren MJ, Markowitz M, Gerber MA. Rheumatic
heart disease in developing countries: the consequence of
inadequate prevention. Ann Intern Med 1994; 120:243-5.
2. Madiyono B. Epidemiologi penyakit jantung reumatik di
Indonesia. J Kardiol Indones 1995;200:25-33.
3. Kumar R, RaizadaA, Aggarwal AK, Ganguly NK. A community-
based rheumatic fever/rheumatic heart disease cohort: twelve-
year experience. Indian Heart J 2002;54:54-8.
4. Padmavati S. Rheumatic fever and rheumatic heart
disease in India at the turn of the century. Indian Heart J
2001 ;53:35-7.
5. Madiyono B. Kardiologi anak masa lampau, kini, dan masa
mendatang: perannya dalam pencegahan dan penanggulangan
penyakit kardiovaskular. Pidato pada upacara pengukuhan
sebagai guru besar tetap dalam Ilmu Kardiologi Anak, FKUI,
Jakarta, 11 Juni 1997.
6. Lue HC, Wu MH, Hsieh KH. Rheumatic fever recurrences:
controlled study of 3-week versus 4-week benzathine penicillin
prevention programs. J Pediatr 1986; 108:299-304.
7. Isenberg HD. Serum inhibitory and bactericidal titers.
In: Isenberg HD,editor. Clinical microbiology procedurs
handbook. Volume 1. Washington D.C. : American Society
for Microbiology; 1992. p. 1-18.
8. Madiyono B, Moeslichan S, Sastroasmoro S, Budiman I,
Purwanto HS. In: Sastroasmoro S, Ismael S, editors. Dasar-
dasar metodologi penelitian klinis. Edisi ke-2. Jakarta: Sagung
Seto; 2002. p. 259-85.
9. Kamat JR. Rheumatic fever and rheumatic heart disease (RF I
RHD). JACC 2000;32:1433-40.
10. Park MK, Troxler RG. Acute rheumatic fever. In: Park MK,
Troxler RG, editors. Pediatric cardiology for practitioner. 4th
ed. Toronto: Mosby; 2002. p. 304-10.
11. Madiyono B, Djer MM, Sastroasmoro S, Subandrio A, Erfan E.
Inhibiting ability of benzathine penicillin G towards group A
Streptococcus f3-hemolyticus in 21 and 28 days after a single
intramuscular injection. Pediatr Indones 2003;43:136-9.
12. Kaplan EL, Berrios X, Speth J. Pharmacokinetics of
benzathine penicillin G: serum levels during the 28 days
after intramuscular injection of 1.200.000 units. J Pediatr
1989;115: 146-50.
Published
2016-09-26
How to Cite
1.
Iskandar B, Madiyono B, Sastroasmoro S, Putra S, Djer M, Karuniawati A. Comparison of minimal inhibitory and bactericidal capacity of oral penicillin V with benzathine penicillin G to Streptococcus beta--hemolyticus group A in children with rheumatic heart disease. PI [Internet]. 26Sep.2016 [cited 22Nov.2024];48(3):152-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/523
Issue
Vol 48 No 3 (2008): May 2008
Section
Articles

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Received 2016-09-09
Accepted 2016-09-09
Published 2016-09-26