Relationship between lipid profiles with carotid intima--media thickness in children with type I diabetes mellitus
Keywords:
type I DM, Carotid artery tunica intima- media thickness, duration of diabetes, lipid profile
Abstract
Background The major cause of morbidity and mortality inpatients with type I diabetes mellitus is premature and extensive
artherosclerosis. Carotid intima-media thickness (IMT) is
associated with cardivascular risk factors and has been used as a
marker of early artherosclerosis process.
Objective To determine IMT of carotid artery and its relationship
with duration of diabetes, lipid profiles, and mean HbA 1 level.
Methods A cross-sectional study was conducted on patients
with type 1 DM at the Department of Child Health Cipto
Mangunkusumo Hospital. Ultrasound B-mode imaging was
performed to measure the IMT. Age-matched non-diabtetic
subjects served as controls. Statistical significant was assumed
at P<O.S.
Results The mean IMT values of type I DM patients aged < 12
years, 12-18 years, 18+ years were 0.44 (SD 0.03) mm; 0.46
(SD 0.01) mm; 0.51 (SD 0.01) mm, respectively, which were
significantly greater than those of age-matched non-diabetic
subjects which were 0.39 (SD 0.01), 0.41 (SD 0.01) mm, 0.46
(SD 0.01) mm, respectively. Patients with type I DM had a
higher apolipoprotein-Band HDL cholesterol levels than in non-
diabetic subjects. Multiple regression analysis showed that there
was no relationship between total cholesterol, cholesterol LDL,
chronic hyperglycemia (HbA 1) and IMT. However, IMT in type
I diabetes was linearly related with duration of diabetes .
Conclusion Type I DM patients have greater IMT and higher
mean apolipoprotein B. There is a strong correlation between
IMT and duration of diabetes.
References
1. Betteridge DJ. Diabetes, lipoprotein metabolism, and
atherosclerosis. Brit Med Bull1989;45:285-311.
2. Gracia MJ, MeN amara PM, Gordon T, Kannell WB. Morbidity
and mortality in diabetes in the Farmingham's population.
Diabetes 1997;23:105-11.
3. Donaghue RP, Orchad TJ. Diabetes mellitus and micro
vascular complication. An epidemiological perspective. Diab
Care 1992;15:1141-55.
4. Bereson GS, Srinivasan SR, Bao W, Newman WP, Tracy RE,
Westtigney W A. Association between multiple cardiovascular
risk factors and atherosclerosis in children and young adult. N
Eng! J Med 1998;338: 1650-6.
5. Sperling MA. Diabetes mellitus. In: Sperling MA, editor.
Pediatric endocrinology. 2nd ed. Philadelphia: Saunders;
2002. p. 323-66.
6. Singh TP, Groehn H, Kazmers A. vascular function
and carotid intima-media thickness in children with
insulin-dependent diabetes mellitus. J Am Coll Cardiol
2003;41:661-5.
7. Fathi R, Marwick TH. Noninvasive test of vascular function
and structure: Why and how to perform them. Am Heart J
2001;141:694-703.
8. American Academy of Pediatrics, Committee on Nutrition.
Cholesterol in childhood. Pediatrics 1998;101:141-7.
9. Indriyanti RS. Pemeriksaan laboratorium untuk diagnosis
dan pemantauan diabetes mellitus. Forum diagnosticum.
2003;4.
10. J arvisalo MJ, Raitakari M, Tiokka JO, Putto-Laurila A, Rontu
T, Laine S, et al. Endothelial dysfunction and increase arterial
intima-media thickness in children with type 1 diabetes.
Circulation 2004;109:1750-5.
11. Jarvisalo MJ, Putto-Laurila A, Jaratti L, Letimaki T,
Solakivi T, Ronnemaa T, et al. Carotid intima-media
thickness in children with type 1 diabetes. Diabetes
2002;51 :493-8.
12. MC Hill HC, Arias-Stella J, Carbonell LM, Cornea P, De
Vaaryearsa EA, Donoso S, et al. Relationship of atherosclerosis
in young men to serum lipoprotein cholesterol concentration
and smoking. JAMA 1990;264:3018-24.
13. Becker DJ. Complications of insulin-dependent diabetes
mellitus in childhood and adolescence. Pediatric Endocrinology
1996;593-605.
14. Patrikiou-Peppa M, Scordili M, Antoniou A, Giannaki M,
Dracopolou M, Dacau-Vountakis C. Carotid atherosclerosis
in adolescents and young adults with IDDM. Diabetes care
1998;21: 1004-7.
15. Hayaishi-Okano R, Yamasaki Y, Katakam N, Ohtoshi K,
Gorgawa S, Kuroda A. Elevated C-reactive protein associates
with early-stage carotid atherosclerosis in young subjects with
type 1 diabetes. Diabetes care 2002;25:1432-8.
16. Lipman TH, Hayman LL, Fabian CV, Difazio DA, Male
PM, Goldsmith BM. Risk factors for cardiovascular
disease in children with type 1 diabetes. Nursing research
2000;49:27 -81.
17. Jarvisalo MJ, Jaratti L, Nanato-Salonen K, Irjala K,
Ronnemaa T, Hartiala JJ, et al. Increase aortic intima-media
thickness a marker of preclinical atherosclerosis in high risk
children. Circulation 2001;104:2943-7.
18. Kawamori R, Yamasaki Y, Matsushima H, Nizhizawa H, Nao
K, Hougaku H, et al. Prevalence of carotid atherosclerosis in
diabetic patients: ultrasound high-resolution B-mode imaging
on carotid arteries. Diabetes Care 1992; 15:1290-4.
19. Tonstad J, Joakimsen 0, Stensland-Bugge E, Leren TP, Ose
L, Russel D, et al. Risk factors related to carotid intima-
media thickness and plaque in children with familial
hypercholesterolemia and control subjects. Arterioscler
Thromb Vase Biol1996;16:984-91.
20. Virkola K, Posonen E, Akerblom HK, Siimes MA.
Cholesterol and carotid artery wall in children and
adolescents familial hypercholesterolemia: a control study
by ultrasound. Acta Pediatr 1997 ;86: 1203-7.
21. Singh TP, Groehn H, Kazmers A. Vascular function
and carotid intima-media thickness in children with
insulin-dependent diabetes mellitus. J Am Coll Cardiol
2003;41:661-5.
22. Pujia A, Gnasso A, Irace C, Colonna A, Mattioli PL.
Common carotid arterial wall thickness in NIDDM subjects.
Diab Care 1994;17:1330-6.
atherosclerosis. Brit Med Bull1989;45:285-311.
2. Gracia MJ, MeN amara PM, Gordon T, Kannell WB. Morbidity
and mortality in diabetes in the Farmingham's population.
Diabetes 1997;23:105-11.
3. Donaghue RP, Orchad TJ. Diabetes mellitus and micro
vascular complication. An epidemiological perspective. Diab
Care 1992;15:1141-55.
4. Bereson GS, Srinivasan SR, Bao W, Newman WP, Tracy RE,
Westtigney W A. Association between multiple cardiovascular
risk factors and atherosclerosis in children and young adult. N
Eng! J Med 1998;338: 1650-6.
5. Sperling MA. Diabetes mellitus. In: Sperling MA, editor.
Pediatric endocrinology. 2nd ed. Philadelphia: Saunders;
2002. p. 323-66.
6. Singh TP, Groehn H, Kazmers A. vascular function
and carotid intima-media thickness in children with
insulin-dependent diabetes mellitus. J Am Coll Cardiol
2003;41:661-5.
7. Fathi R, Marwick TH. Noninvasive test of vascular function
and structure: Why and how to perform them. Am Heart J
2001;141:694-703.
8. American Academy of Pediatrics, Committee on Nutrition.
Cholesterol in childhood. Pediatrics 1998;101:141-7.
9. Indriyanti RS. Pemeriksaan laboratorium untuk diagnosis
dan pemantauan diabetes mellitus. Forum diagnosticum.
2003;4.
10. J arvisalo MJ, Raitakari M, Tiokka JO, Putto-Laurila A, Rontu
T, Laine S, et al. Endothelial dysfunction and increase arterial
intima-media thickness in children with type 1 diabetes.
Circulation 2004;109:1750-5.
11. Jarvisalo MJ, Putto-Laurila A, Jaratti L, Letimaki T,
Solakivi T, Ronnemaa T, et al. Carotid intima-media
thickness in children with type 1 diabetes. Diabetes
2002;51 :493-8.
12. MC Hill HC, Arias-Stella J, Carbonell LM, Cornea P, De
Vaaryearsa EA, Donoso S, et al. Relationship of atherosclerosis
in young men to serum lipoprotein cholesterol concentration
and smoking. JAMA 1990;264:3018-24.
13. Becker DJ. Complications of insulin-dependent diabetes
mellitus in childhood and adolescence. Pediatric Endocrinology
1996;593-605.
14. Patrikiou-Peppa M, Scordili M, Antoniou A, Giannaki M,
Dracopolou M, Dacau-Vountakis C. Carotid atherosclerosis
in adolescents and young adults with IDDM. Diabetes care
1998;21: 1004-7.
15. Hayaishi-Okano R, Yamasaki Y, Katakam N, Ohtoshi K,
Gorgawa S, Kuroda A. Elevated C-reactive protein associates
with early-stage carotid atherosclerosis in young subjects with
type 1 diabetes. Diabetes care 2002;25:1432-8.
16. Lipman TH, Hayman LL, Fabian CV, Difazio DA, Male
PM, Goldsmith BM. Risk factors for cardiovascular
disease in children with type 1 diabetes. Nursing research
2000;49:27 -81.
17. Jarvisalo MJ, Jaratti L, Nanato-Salonen K, Irjala K,
Ronnemaa T, Hartiala JJ, et al. Increase aortic intima-media
thickness a marker of preclinical atherosclerosis in high risk
children. Circulation 2001;104:2943-7.
18. Kawamori R, Yamasaki Y, Matsushima H, Nizhizawa H, Nao
K, Hougaku H, et al. Prevalence of carotid atherosclerosis in
diabetic patients: ultrasound high-resolution B-mode imaging
on carotid arteries. Diabetes Care 1992; 15:1290-4.
19. Tonstad J, Joakimsen 0, Stensland-Bugge E, Leren TP, Ose
L, Russel D, et al. Risk factors related to carotid intima-
media thickness and plaque in children with familial
hypercholesterolemia and control subjects. Arterioscler
Thromb Vase Biol1996;16:984-91.
20. Virkola K, Posonen E, Akerblom HK, Siimes MA.
Cholesterol and carotid artery wall in children and
adolescents familial hypercholesterolemia: a control study
by ultrasound. Acta Pediatr 1997 ;86: 1203-7.
21. Singh TP, Groehn H, Kazmers A. Vascular function
and carotid intima-media thickness in children with
insulin-dependent diabetes mellitus. J Am Coll Cardiol
2003;41:661-5.
22. Pujia A, Gnasso A, Irace C, Colonna A, Mattioli PL.
Common carotid arterial wall thickness in NIDDM subjects.
Diab Care 1994;17:1330-6.
Published
2016-09-26
How to Cite
1.
Sukardi R, Madiyono B, Sastroasmoro S, Batubara J. Relationship between lipid profiles with carotid intima--media thickness in children with type I diabetes mellitus. PI [Internet]. 26Sep.2016 [cited 22Nov.2024];48(3):147-1. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/522
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Received 2016-09-09
Accepted 2016-09-09
Published 2016-09-26
Accepted 2016-09-09
Published 2016-09-26
