Correlation between interleukin-6 and septic shock in children
Abstract
Background Sepsis is a lifeô€†threatening condition and the most
common cause of death in intensive care units in developing
countries, such as Indonesia. The first clinical signs of sepsis are
usually nonô€†spedfic. More specific signs and laboratory parameters
often occur late and are associated 'With organ dysfunction and
high mortality rates. Interleukinô€†6 (IL--6) is a biomarker reported to
be superior to clinical signs and conventional tests for sepsis. IL--6
levels may indicate microorganism invasion, as well as progression
of infection into sepsis, severe sepsis, and septic shock.
Objective To evaluate a correlation between interleukin (IL)ô€†6
and septic shock in children
Methods This crossô€†sectional study was conducted in the pediatric
intensive care unit of Prof. Dr. R.D. Kandou Hospital, Manado,
between June to September 2011. Subjects were children with
sepsis or septic shock aged 1 month to 13 years, v.ith diagnoses
based on the International Pediatric Sepsis Consensus Conference
Criteria 2005. A oneô€†time measurement of IL--6 plasma levels
was done at the time of diagnosis. Data was analyzed by logistic
regression test using SPSS version 17 software. A P value of <0.05
indicated statistical significance.
Results The mean IL--6 plasma level in the septic group was 1.68
(95%CI 1.45 to 1.91) pg/mL and that of the septic shock group
was 2.33 (95%CI 1.79 to 2.86) pg/mL. Our results showed a
strong positive correlation between ILô€†6 plasma levels v.ith the
probability of septic shock in children v.ith sepsis (regression
coefficientô€‡1.3lO, Pô€‡O.024).
Conclusion Higher plasma IL--6 levels were associated v.ith a
higher risk of septic shock in children with sepsis. [Paediatr
rndones.2012;52:352-5].
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Accepted 2016-09-08
Published 2012-12-31
