Neurodevelopmental disorder risk in babies with history of hyperbilirubinemia

Main Article Content

Baginda Hutahaean
Alifiani Hikmah Putranti
Kamilah Budhi Rahardjani

Abstract

Background Neurodevelopmental disorder (ND) is defined as
failure to attain normal neurological function. Indirect bilirubin
has essential role because its neurotoxic properties. Neonates with
hyperbilirubinemia carry the risk to develop ND.
Objective To determine the association between neonatal indirect
hyperbilirubinemia and the risk of ND.
Methods Neonates with indirect serum bilirubin (SIB) level >10
mg/dL, admitted in the period of October 2004-August 2005, were
included in this study. They were followed-up and screened using
Bayley Infant Neurodevelopmental Screener (BINS) at three, six
and nine months. Mann-Whitney test was used to test the
hypothesis.
Results Forty-eight neonates were included in the study. Mean
SIB level of subjects with ND risk was 20.5 mg/dL (SD=6.06;
p<0.001). Mean SIB level of subjects who developed ND at three,
six and nine months was 31.6 mg/dL (SD=4.02), 18.4 mg/dL
(SD=2.92) and 18.4 mg/dL (SD=5.41), respectively. There was
statistically significant correlation between SIB level and ND
risk (R=+0.64; P<0.001). There was also statistically significant
correlation between SIB level and the onset of ND (R=-0.63;
P< 0.001).
Conclusion There is a correlation between neonatal SIB level
and the risk of ND in babies.

Article Details

How to Cite
1.
Hutahaean B, Putranti A, Rahardjani K. Neurodevelopmental disorder risk in babies with history of hyperbilirubinemia. PI [Internet]. 1May2008 [cited 25Jul.2021];48(2):93-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/485
Section
Articles
Author Biographies

Baginda Hutahaean

Department of Child Health, Medical School, Diponegoro
University, Semarang, Indonesia.

Alifiani Hikmah Putranti

Department of Child Health, Medical School, Diponegoro
University, Semarang, Indonesia.

Kamilah Budhi Rahardjani

Department of Child Health, Medical School, Diponegoro
University, Semarang, Indonesia.
Received 2016-09-07
Accepted 2016-09-07
Published 2008-05-01

References

1. Saharso D. Gangguan perkembangan neurologis. In:
Firmansyah A, Sastroasmoro S, Trihono PP, editors. Naskah
lengkap KONIKA XI. Jakarta: IDAI Pusat; 1999. p. 571-88.
2. Njiokiktjien C, Panggabean R, Hartono B. Masalah-masalah
dalam perkembangan psikomotor. Semarang: Wonodri Offset
Ltd; 2003. p. 1-55.
3. Kliegman RM. Jaundice and hyperbilirubinemia in the
newborn. In: Nelson WE, Behrman RE, Kliegman R, Arvin
AM, editors. Nelson textbook of pediatrics. 16th ed.
Philadelphia: WB Saunders Co; 2000. p. 610-6.