Effects of live versus heat-killed probiotics on acute diarrhea in young children
Abstract
Background Diarrhea remains one of the major causes of
morbidity and mortality in children in developing countries.
Probiotics have been shown to be beneficial for decreasing the
frequency and duration of diarrhea. However, the reported effects
on reducing the duration of diarrhea have been varied.
Objective To compare the effectiveness of live and heatô€‚killed
probiotics in 6ô€‚60 monthô€‚old children with acute diarrhea for
decreasing duration and frequency of diarrhea and improving
weight gain.
Methods We conducted a randomized, singleô€‚blind, controlled
trial in children aged 6ô€‚60 months with acute diarrhea. Children
were randomized into two groups, receiving either live or heatô€‚
killed probiotics. All children received standard treatment for
diarrhea and probiotics as adjuvant treatment. The primary
outcomes were duration and frequency of diarrhea, as well as
weight gain. Tô€‚test was used for data analysis.
Results There were 165 children with acute diarrhea enrolled
in this study. They were divided into 2 groups, with 83 children
receiving live probiotics and 82 children receiving heatô€‚killed
probiotics. There were no significant differences in diarrheal
duration in the two groups. The mean durations of diarrhea in
the live and heatô€‚killed probiotic groups were 3.64 (SD 0.85) days
and 3.74 (SD 0.73) days (P>0.05), respectively. Mean diarrheal
frequencies were also not significantly different, with 3.25 (SD
1.44) times per day in the live probiotic group and 3.26 (SD 1.20)
times per day in the heatô€‚killed probiotic group (P>0.05). In
addition, mean weight gain was not significantly different, 'With
241.57 (SD 75.84) g in the live prohiotic group and 221.95 (SD
85.38) g in the heat-killed prohiotic group (P>0.05).
Conclusion There were no significant differences between live and
heatô€‚killed probiotics for reducing duration and frequency of diarrhea,
as well as in weight gain in children aged 6ô€‚60 months 'With acute
diarrhea. [paediatr lndones. 2012;52:249-54].
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Accepted 2016-09-07
Published 2012-10-31
