Toxoplasma gondii immunoglobulin G in paired infant-and-mother sera
Keywords:
seropositive, T. gondii, lgG, paired infant and mother, incidence
Abstract
Background Toxoplasmosis is a worldwide zoonotic diseasecaused by Toxoplasma gondii. Congenital toxoplasmosis (CT)
is the result of vertical transmission during pregnancy that
may cause pathologic effects on the newborn such as classical
triad of congenital toxoplasmosis. Newborn humans are not
immunologically competent and the infant must be protected by passive lgG antibodies that are selectively transported across the placenta during development. We studied the transfer of passive lgG from the mother to developing infant using blood specimen taken from the infant within one month of birth.
Objective To determine the seropositivity of lgG to T. gondii in paired sera of infants and mothers.
Methods A cross sectional study was carried out on 50 paired
sera of infants of less than one month of age and their mothers. The study was carried out between November 2007 and January 2008 at Prof. R. D. Kandou Hospital in Manado. T. gondii lgG was detected using the Latex Agglutination method. The seropositivity ofT. gondii lgG was analyzed descriptively.
Results A total of 28 mothers from 50 infant-mother pairs were
seropositive for T. gondii IgG. Of the 28 seropositive mothers, 22 of their paired infants were seropositive. The remaining six seropositive mothers had infants that were not seropositive for T. gondii.
Conclusions The identification of seropositive lgG for T. gondii in infants less than one months age indicates that the lgGs in infants are mostly derived from their mothers. CT must be considered and further examinations are needed.
References
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Indonesia. 1999;12:S33-40.
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sebagai indikator toxoplasmosis kongenital serta korelasinya
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Protect. 1999;62:818-29.
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15. Sanjaya A. Studi uji komparasi hasil pemeriksaan metode
ELISA dan aglutinasi latex dalam pemeriksaan antibodi lgG
Toxoplasma gondii pada wanita hamil di Puskesmas Pegirian
Surabaya [thesis]. Surabaya: Airlangga University; 2006.
16. Wallon M, Kodjikian L, Binquet C, GarwegJ, Fleury J, Quantin C, et al. Long term ocular prognosis in 327 children with congenital toxoplasmosis. Pediatrics. 2004; 113:1567-72.
17. Filisseti D, Gorcii M, Marino EP, Villard 0, Candolfi E.
Diagnosis of congenital toxoplasmosis, comparison of targets
for detection of Toxoplasma gondii by PCR. J Clin Microbial.
2003; 41:S4826-29.
18. Guerina NG, Hsu HW, Meissner C, Maguire JH. Neonatal
serologic screening and early treatment for congenital
Toxoplasma gondii infection. N Engl J Med. 1994; 330:1858-63.
19. Remington JS. Infectious diseases of the fetus and newborn infant. 4th ed. Philadelphia: WB Saunders, 1983; p. 140-260.
20. Male D, Brostoff J, Roth DB, Raitt I. Antibodies. In: Raitt IM, Male DK, editors. Immunology. 7'" ed. Philadelphia:
Mosby Elsevier. 2006; p. 59-86.
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Toxoplasma gondii infection during pregnancy. Indian J Med
Micro bioi. 2003;21 :S69-76.
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Fundamental immunology. 5th ed. Lippincott William and
Wilkins. 2003;p. 1-22.
23. Kami Kim. Time to screen for congenital toxoplasmosis.
Chicago J Clin Infect Dis. 2006;42: 1395-97.
Muradiano V, Soares RM. Seroprevalence of toxoplasmosis
in a low income community in the Sao Paulo Municipality
SP Brazil. Rev Inst Med Trop Sao Paulo. 2006;48 :S167-
170.
2. Tenter AM, Heckeroth AR, Weiss LM. Epidemiological aspects
of toxoplasmosis in school children residing in localities with
urban or rural characteristics within the city of Rio de Janeiro,
Brazil. Mem lnst Oswaldo Cruz. 1987;82:475-82.
3. Jones JF, Lopez B, Mury MAY, Wilson M, Klein R, Luby S, Maguire JH. Toxoplasma gondii infection in rural Guatemalan
children. Am J Trop Med Hyg. 2005;72:295-300.
4. Montoya JG, Lieasenfield 0. Toxoplasmosis. Lancet.
2004;363: 1965-76.
5. Dubey JP. Toxoplasmosis, sarcocystosis, isosporosis and
cyclosporosis. In: Palmer SR, Soulby EJL, Simpson DJH,
editors. Zoonoses. Oxford: Oxford University Press, 1998;
p. 579-97.
6. Tenter AM, Heckeroth AR, Weiss LM. Toxoplasma gondii:
From animals to humans. Int J Parasit. 2000;30: 1217-58.
7. Rampengan TH, Laurentz IR. Penyakit infeksi tropik pada
anak. 1" ed. Jakarta: Penerbit Buku Kedokteran EGC,1997;
p.245-55.
8. Thulliez P. Commentary: Efficacy of prenatal treatment for
toxoplasmosis: A possibility that can not be ruled out. Int J
Epidemiol. 2001 ;30:S1315-6.
9. Gandahusada. Parasitologi Kedokteran. Jrd ed. Jakarta: Balai Penerbit Fakultas Kedokteran Universitas Indonesia, 1998;
p.153-61.
10. Rochiman Sasmita. Toxoplasmosis penyebab keguguran dan
kelainan bayi. Surabaya: Airlangga University Press, 2006;
p. 23-40.
11. Dachlan E.G. Congenital toxoplasmosis: Fetal antibodies
production in amniotic fluid. Majalah Kedokteran Tropis
Indonesia. 1999;12:S33-40.
12. Dachlan E.G. IgM anti toxoplasma dalam cairan ketuban
sebagai indikator toxoplasmosis kongenital serta korelasinya
dengan IgM anti toxoplasma seromaternal [dissertation].
Surabaya: Airlangga University; 1999.
13. Smith JL. Foodborne infections during pregnancy. J Food
Protect. 1999;62:818-29.
14. Holliman RE. Toxoplasmosis. In: Cook GC. Manson Tropical
Diseases. 21" ed. London: WB Saunders; 1996:1365-72.
15. Sanjaya A. Studi uji komparasi hasil pemeriksaan metode
ELISA dan aglutinasi latex dalam pemeriksaan antibodi lgG
Toxoplasma gondii pada wanita hamil di Puskesmas Pegirian
Surabaya [thesis]. Surabaya: Airlangga University; 2006.
16. Wallon M, Kodjikian L, Binquet C, GarwegJ, Fleury J, Quantin C, et al. Long term ocular prognosis in 327 children with congenital toxoplasmosis. Pediatrics. 2004; 113:1567-72.
17. Filisseti D, Gorcii M, Marino EP, Villard 0, Candolfi E.
Diagnosis of congenital toxoplasmosis, comparison of targets
for detection of Toxoplasma gondii by PCR. J Clin Microbial.
2003; 41:S4826-29.
18. Guerina NG, Hsu HW, Meissner C, Maguire JH. Neonatal
serologic screening and early treatment for congenital
Toxoplasma gondii infection. N Engl J Med. 1994; 330:1858-63.
19. Remington JS. Infectious diseases of the fetus and newborn infant. 4th ed. Philadelphia: WB Saunders, 1983; p. 140-260.
20. Male D, Brostoff J, Roth DB, Raitt I. Antibodies. In: Raitt IM, Male DK, editors. Immunology. 7'" ed. Philadelphia:
Mosby Elsevier. 2006; p. 59-86.
21. Singh S. Mother to child transmission and diagnosis of
Toxoplasma gondii infection during pregnancy. Indian J Med
Micro bioi. 2003;21 :S69-76.
22. Paul WE. The immune system. In: Paul WE, editor.
Fundamental immunology. 5th ed. Lippincott William and
Wilkins. 2003;p. 1-22.
23. Kami Kim. Time to screen for congenital toxoplasmosis.
Chicago J Clin Infect Dis. 2006;42: 1395-97.
Published
2009-04-30
How to Cite
1.
Sanjaya A, Masloman N, Wilar R, Tuda J. Toxoplasma gondii immunoglobulin G in paired infant-and-mother sera. PI [Internet]. 30Apr.2009 [cited 13Nov.2024];49(2):65-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/458
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Received 2016-09-05
Accepted 2016-09-05
Published 2009-04-30
Accepted 2016-09-05
Published 2009-04-30
