Blood nickel level and its toxic effect after transcatheter closure of persistent duct arteriosus using Amplatzer duct occluder

  • Mulyadi M. Djer
  • Bambang Madiyono
Keywords: patent ductus arteriosus, amplatzer duct occluder, nickel, nitinol, inductively coupled plasma spectrometry

Abstract

Background  Transcatheter closure using amplatzer  duct  occluder
(ADO)  is  currently the  treatment  of  choice for  patent  ductus
arteriosus (PDA).  The  ADO  device  is  constructed from a Nitinol
wire mesh containing 55% nickel. Up  to  now, there  is  still a
controversy about the effects  of  nickel contained in ADO.
Objectives  To  determine blood nickel level  at  six months after
transcatheter closure  of  PDA  using  ADO,  toxic effects  of  nickel
at six months after  PDA  closure using  ADO,  and the effects  of
nickel  on  complete blood  count  (CBC), blood glucose and renal
function.
Methods  Subjects  were  patients  with  PDA  at  Integrated
Cardiovascular Services,  Dr.  Cipto Mangunkusumo Hospital,
Jakarta. Routine blood test and blood nickel levels were measured
at  the time  of  the procedure,  and  at  the  end  of  the first, third,  and
sixth months after intervention.
Results  There  were  29  patients who underwent heart catheteri-
zation  and  PDA closure using  ADO.  A time series analysis was
conducted  on  23  patients who completed six-month follow-up
after the intervention. Median blood nickel level before procedure
was 58 ng/mL while  at  one, three  and  six months afterwards were
60, 63 and 64 ng/mL respectively.  The  blood nickel levels did
not  differ significantly between pre- and  post-ADO. After  PDA
closure,  no  toxic effects  of  nickel were found,  both  clinically and
laboratorically.
Conclusions  PDA  closure using  ADO  has no effects  on  the nickel
levels, CBC, blood glucose and renal function;

Author Biographies

Mulyadi M. Djer
Child Health Department, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Bambang Madiyono
Child Health Department, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

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Published
2009-03-01
How to Cite
1.
Djer M, Madiyono B. Blood nickel level and its toxic effect after transcatheter closure of persistent duct arteriosus using Amplatzer duct occluder. PI [Internet]. 1Mar.2009 [cited 13Nov.2024];49(1):33-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/453
Section
Articles
Received 2016-09-05
Accepted 2016-09-05
Published 2009-03-01