Preterm and low birth weight as risk factors for infant delayed development
Abstract
Background In developed countries, birth weight of less than1,500 g contributes in infant delayed development. It might be
different in developing countries.
Objective This study aimed to determine whether preterm infants
with birth weight of 1,500 to 2,499 g are risk factors for delayed
development at 7-10 months of age.
Methods We analyzed singleton infants at 7-10 months of
corrected age, born with birth weight of 1,500 to 2,499 grams,
preterm-appropriate for gestational age (or LBW group), and at
7-10 months of chronological age, born with birth weight >2,500
g-term-appropriate for gestational (non-LBW group) in a hospital-
based retrospective cohort study. Data were taken from medical
records in Hasan Sadikin Hospital, Bandung, from September
2003 to May 2004. We excluded infants with major congenital
anomalies, hyaline membrane disease, assisted ventilation, or
exchange transfusion. Multiple regression logistic analysis was
performed for data analysis.
Results The percentage of delayed development in LBW group
was higher than in non-LBW group (17.1% vs. 1.6%). Logistic
regression analysis revealed that low birth weight was a risk factor
for delayed development (RR=5.13, 95%Cl 1.55;16.96, P=0.007).
Other biological risk factors for delayed development are
hyperbilirubinemia (RR=3.32, 95%Cl 1.29;8.54, P=0.013) and
sepsis (RR=2.74, 95%Cl 1.15;6.52, P=0.023).
Conclusions Preterm-appropriate for gestational age with birth
weight of 1,500 to 2,499 g are risk factors for infant delayed
development after being adjusted to other biological risk factors.
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Accepted 2016-09-04
Published 2008-02-29