Main Article Content
over the past few decades and its morbidity interferes with the
quality of life and health. Prediction of the disease is important
for early prevention.
Objective To evaluate the relationship between atopic
manifestations, family history (FH) of atopic disease and cord
blood IgE (CB-IgE) levels.
Methods We conducted an analytic observational study with
cohort retrospective design on children with an average age of 3
years whose CB-IgE had been measured at delivery in
Kiaracondong Primary Health Care during October–December
2004. Manifestations of atopic disease were recorded using ISAAC
questionaire for allergy. Chi-square, Mann-Whitney test, and
logistic regression analysis were used for analysis.
Results Cord blood IgE was measured on 124 children after birth.
Only 94 children (76%) fulfilled the inclusion criteria. Atopic
disease was found in 17 children (18%), consisting of 8 children
with atopic dermatitis, 4 with allergic rhinitis, and 5 suffered from
both. There were significant differences in the mean value of CB-
IgE (Z M-W =4.60; P<0.001) and FH (x 2 =19.059; P<0.001)
between atopic and non atopic children. Cut off point of the CB-
IgE concentration was 1.4 IU/mL (77.7%). The highest probability
for atopic manifestations was found in children who had high
CB-IgE and positive FH (P=45%). Relative risk of children with
high CB-IgE level in positive FH group was 3.636 (95% CI
Conclusion CB-IgE level and family history of atopic disease are
risk factors for the development of atopic manifestation.
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
in infants with atopic dermatitis. Pediatr Allergy Immunol
2. Yadav M. Maternal factors in atopy. Medical Progress
3. Kristal L., Klein PA. Atopic dermatitis in infants and children.
An update. Ped Clin North Am 2000;47:877-95.
4. The International Study of Asthma and Allergies in
Childhood (ISAAC) Steering Committee. Lancet 1998;
5. Kay J, Gawkrodger DJ, Mortimer MJ, Jaron AG. The
prevalence of childhood atopic eczema in general population.
J Am Acad Dermatol 1994; 30:35-9.
6. Arshad SH, Babu KS, Holgate. Anti-IgE therapy in asthma
and allergy. London: Martin Dunitz; 2001.
7. Wahn U, Matius E. Current reviews of allergy and clinical
immunology. Childhood risk factors for atopy and the
importance of early intervention. J Allergy Clin Immunol
8. Hopkin JM. Genetics of atopy. Pediatr Allergy Immunol
9. Morgan J, Williams P, Noris F, Williams CM, Larkin M,
Hampton S. Eczema and early solid feeding in peterm infants.
Arch Dis Child 2004;89:309-14.
10. Johansson SGO, Hourihane JO’B, Bousquet J, Bruijnzeel-
Koomen C, Dreborg S, Haahtela T, et al. A revised nomenclature
for allergy. An EAACI position statement from the EAACI
nomenclature task force. Allergy 2001;56:813-24.
11. Johansson SGO, Bieber T, Dahl R, Freidmann PS, Lanier
BQ, Locley RF, et al. Revised nomenclature for allergy for
global use: report of the nomenclature review committee of
the World Allergy Organization, October 2003. J Allergy Clin
12. Terr AI. The atopic diseases. In: Parslow TG, Stites DP, Terr
AI, Imboden JB, editors. Medical immunology. 10 th ed. New
York: McGraw-Hill Co; 2001. p. 349-69.
13. Kjellman NAM, Johansson SGO. IgE and atopic allergy in
newborn and infants with a family history of atopic disease.
Acta Pediatr Scand 1976;65:601-7.
14. Savelkoul HFJ, Neijens HJ. Immune responses during allergic
sensitization and the development of atopy. Allergy
15. Gerrard JW, Horne S, Vickers P, MacKenzie JWA, Goluboff
N, Garson JZ, et al. Serum IgE levels in parents and children.
J Pediatr 1974;85:660-3.
16. Jones CA, Holloway JA, Warner JO. Does atopic disease start
in foetal life? Allergy 2000;55:2-10.
17. Kay AB. Allergy and allergic diseases. Advances in
immunology. N Engl J Med 2001;1:30-7.
18. Croner S, Kjellman NIM, Eriksson B, Roth A. IgE screening
in 1701 newborn infants and the development of atopic
disease during infancy. Arch Dis Child 1982;57:364-8.
19. Edenharter G, Bergmann RL, Bergmann KE, Wahn U, Fostr
J, Zepp F, et al. Cord blood IgE as risk factor and predictor for
atopic diseases. Clin Exp Allergy 1998;28:671-8.
20. Eiriksson TH, Sigurgeisson B, Sigfusson A, Valdimarsson H.
Cord blood IgE levels are influenced by gestational age but
do not predict allergic manifestations in infants. Pediatr
Allergy Immunol 1994;5:5-10.
21. Hutapea AT, Setiabudiawan B, Soepriadi M, Rustama DS.
Association between cord blood IgE levels in newborns and
family history of atopic diseases. Paediatr Indones
22. Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez
F, et al. International study of asthma and allergies in
childhood (ISAAC): rationale and methods. Eur Respir J
23. Zeiger RS. Food allergen avoidance in the prevention of
food allergy in infants and children. Pediatrics 2003;