Quality of life in children with cancer and their normal siblings

Hilda Hilda; Bidasari Lubis; Hakimi Hakimi; Olga Rasiyanti Siregar

doi:10.14238/pi55.5.2015.243-7

Hilda Hilda Department of Child Health, University of Sumatera Utara Medical School/H. Adam Malik Hospital, Medan, North Sumatera,Indonesia
Bidasari Lubis Department of Child Health, University of Sumatera Utara Medical School/H. Adam Malik Hospital, Medan, North Sumatera,Indonesia
Hakimi Hakimi Department of Child Health, University of Sumatera Utara Medical School/H. Adam Malik Hospital, Medan, North Sumatera,Indonesia
Olga Rasiyanti Siregar Department of Child Health, University of Sumatera Utara Medical School/H. Adam Malik Hospital, Medan, North Sumatera,Indonesia

DOI: https://doi.org/10.14238/pi55.5.2015.243-7

Keywords: child cancer, quality of life, Peds-QL

Abstract

Background Cancer treatment in children influences the quality of life of patients and their families. The Pediatric Quality of Life (PedsQL) inventory is a questionnaire to assess quality of life of the healthy and ill children. Objective To compare quality of life in children with cancer and their normal siblings, and to compare quality of life in those with hematologic malignancies to those with solid tumors. Methods A cross-sectional study was conducted among 5-to-18- year-olds at the Hematology-Oncology Division at Haji Adam Malik Hospital, Medan, North Sumatera, from May to July 2012. The case group (subjects with cancer) filled the PedsQL 3.0 and 4.0 questionnaires, while the control group (normal siblings) filled only the PedsQL 4.0 questionnaire. Independent T-test was used to compare the quality of life between children with cancer and their normal siblings. Results There were 46 children in each group. The PedsQL 4.0 results in children with cancer and their normal siblings, and PedsQL 3.0 between hematology malignant and solid cancer were as follows: physical function 36.9 vs. 80.7, respectively (95%CI of differences -52.639 to -34.990; P= 0.0001), emotional function 40.4 vs. 69.3, respectively (95%CI of differences -35.912 to -21.914; P=0.0001), social function 71.5 vs. 93.9, respectively (95%CI of differences - 29.238 to -15.587; P=0.0001), school function 20.7 vs. 74.2, respectively (95%CI of differences - 62.124 to -44.832; P=0.0001), and total score 42.1 vs. 79.3, respectively (95%CI of differences - 43.066 to -31.344; P=0.0001). School function was the most affected parameter in children with cancer compared to their normal siblings. Conclusion There is a significant difference in quality of life between children with cancer and their normal siblings, for all four parameters examined by the PedsQL inventory. However, there are no significant differences in quality of life between children with hematologic malignancy and those with solid cancer.

References

Smith MA, Ries LA. Childhood cancer: incidence, survival, and mortality. In: Pizzo P, Poplack D, editors. Principles and practice of pediatric oncology. 3rd ed. Philadelphia: Lippincott Raven; 2005. p.1481-93.

Bagian Penelitian dan Pengembangan, Rumah Sakit Kanker Dharmais, Pusat Kanker Nasional. Laporan Kerja Subbagian Registrasi Kanker: Registrasi kanker berbasis rumah sakit di RSKD tahun 2012. Jakarta: Balitbang RSKD;2012. p.62-5.

Lanzkowsky P. Evaluation, investigation, and management of late effects of childhood cancer. In: Lanzkowsky P, editor. Manual of pediatric hematology and oncology. 4th ed. San Diego: Elsevier Press; 2005. p. 749-73.

Blaauwbroek R, Groenier KH, Kamps WA, Meyboom-de Jong B, Postma A. Late effects in adult survivors of childhood cancer: the need for life-long follow-up. Ann Oncol. 2007;18:1898-1902.

Halyard MY, Ferrans CE. Quality-of-life assessment for routine oncology clinical practice. J Support Oncol. 2008;6:221-9.

Prchal A, Graf A, Bergstraesser E, Landolt MA. A two-session psychological intervention for siblings of pediatric cancer patients: a randomized controlled trial. Child Adolesc Psychiatry Ment Health. 2012;6:1-9.

Wolfe J, Grier HE, Klar N, Levin SB, Ellenbogen JM, Salem-Schatz S, et al. Symptoms and suffering at the end of life in children with cancer. N Engl J Med. 2000;342:326-33.

Stiller CA. Epidemiology and genetics of childhood cancer. Oncogene. 2004;23:6429-44.

Varni JW, Burwinkle TM, Katz ER, Meeske K, Dickinson P. The PedsQLTM in pediatric cancer: reliability and validity of the Pediatric Quality of Life Inventory Generic Core Scales, Multidimensional Fatigue Scale, and Cancer Module. Cancer. 2002;94:2090-106.

Chaudry Z, Siddiqui S. Health related quality of life assessment in Pakistani paediatric cancer patients using PedsQLTM 4.0 generic core scale and PedsQLTM cancer module. Health Qual Life Outcomes. 2012;10:52-66

Ness KK, Hudson MM, Ginsberg JP, Nagarajan R, Kaste SC, Marina N, et al. Physical performance limitations in the Childhood Cancer Survivor Study cohort. J Clin Oncol. 2009;27:2382-9.

Spieth LE, Harris CV. Assessment of health-related quality of life in children and adolescents: an integrative review. J Pediatr Psychol. 1996;21:175-93.

Adamoli L, Deasy-Spinetta P, Corbetta A, Jankovic M, Lia R, Locati A, et al. School functioning for the child with leukemia in continuous first remission: screening high-risk children. Pediatr Hematol Oncol. 1997;14:121-31.

World Health Organization. Towards a common language for functioning disability and health: ICF The International Classification of Functioning, Disability and Health; 2002. [cited 2012 November]. Available from: http://www.who.int/classifications/icf/training/icfbeginnersguide.pdf.

Hudson MM, Mertens AC, Yasui Y, Hobbie W, Chen H, Gurney JG, et al. Health status of adult long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. JAMA. 2003;290:1583-92.

Punyko JA, Gurney JG, Scott Baker K, Hayashi RJ, Hudson MM, Liu Y, et al. Physical impairment and social adaptation in adult survivors of childhood and adolescent rhabdomyosarcoma: a report from the Childhood Cancer Survivors Study. Psychooncology. 2007;16:26-37.

Schor N, Lottick K, Worth L, Bleyer A, Tubergen D, Bradley B, et al. Cancer and benign tumors. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, editors. Nelson pediatrics. 18th ed. Philadelphia: Sanders Company; 2008. p. 2091-162.

Landolt MA, Vollrath M, Niggli FK, Gnehm HE, Sennhauser FH. Health-related quality of life in children with newly diagnosed cancer:a one year follow-up study. Health Qual Life Outcomes. 2006;4:63-70.

Calaminus G, Kiebert G. Studies on health-related quality of life in childhood cancer in the European setting: an overview. Int J Cancer Suppl. 1999;12:83-6.