Oral erythromycin for treatment of gastrointestinal dysmotility in premature infants
Keywords:
erythromycin, gastrointestinal dysmotility, preterm infants
Abstract
Background Functional immaturity of gastrointestinal (GI)motility predisposes preterm infants to feeding intolerance.
Erythromycin as a prokinetic agent has been given to preterm
infants for the management of non-obstructive GI dysmotility.
Objective To evaluate the efficacy of oral erythromycin for the
treatment of GI dysmotility in preterm infants.
Methods A randomized controlled clinical trial was done at Adam
Malik Hospital and Pirngadi Hospital, Medan, between October
2004 – March 2005. Fifty preterm infants with feeding intolerance
were randomly assigned to either receive oral erythromycin (12.5
mg/kg, every 6 hours) or placebo for 7 days. Improved tolerance
for enteral feedings was evaluated by the amount of gastric residue
before feeding.
Results On the sixth day, there was a significant difference in the
amount of residue from gastric residue between the oral
erythromycin group and placebo group (mean 21.7 and 29.4;
P<0.05) and so were results on the seventh day (mean 14.1 and
26.9; P<0.05).
Conclusion Oral erythromycin reduces the amount of gastric
residue before feed in premature infants.
References
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different pathways in the motor effects of erythromycin on
the gastric antrum in humans. Gut 1998;43:395-400.
11. Jadcheria SR, Berseth CL. Effect of erythromycin on
gastroduodenal contractile activity in developing neonates.
J Pediatr Gastrol Nutr 2002;34:16-22.
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P. Motilin receptors in the human antrum. Am J Physol 2000;
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internasional. Medan: BIKA FK USU; 2003. p. 500-16.
15. Patole SK, Rao S, Doherty D. Erythromycin as a prokinetic
agent in preterm neonates-a systematic review. Arch Dis
Child Fetal Neonatal 2005;90:F301-6.
16. Slater-Myer LP, Saslow JG, Stahl GE. Development of the
gastrointestinal tract. In: Spitzer AR, editor. Intensive care
of the fetus and neonate. St Louis: Mosby; 1996. p. 843-56.
In: Lebenthal E, editor. Textbook of gastroenterology and
nutrition in infancy. 2 th ed. New York: Raven Press; 1989. p.
1293-1309.
2. Kliegman RM. Studies of feeding intolerance in very low birth
weight infants: Definition and significance. Pediatrics 2002;
109:516-7.
3. Stenson BJ, Middlemist L, Lyon AJ. Influence of erythromycin
on establishment of feeding in preterm infants: observations
from a randomised controlled trial. Arch Dis Child Fetal
Neonatal 1998;79:F212-4.
4. Madani A, Pishva N, Pourarian SH, Zarkesh M. The efficacy
of oral erythromycin in enhancement of milk tolerance in
premature infants: a randomised clinical trial. IJMS 2004;
29:1-4.
5. Massachusets Poison Control System. Erythromycin. Clinical
toxicology review 1995. Available from URL: http://
www.maripoisoncenter.com/ctr/9560erythromycin.html.
6. Poets CF. Gastroesophageal reflux: A critical review of its
role in preterm infants. Pediatrics 2004;113:e128-32.
7. Ng PC, So KW, Fung KSC, Lee CH, Fok TH, Wong E et al.
Randomised controlled study of oral erythromycin for
treatment of gastrointestinal dysmotility in preterm infants.
Arch Dis Child Fetal Neonatal 2001;84:F177-82.
8. Zatman TF, Hall JE, Harmer M. Gastric residual volume in
children: a study comparing efficiency of erythromycin and
metoclopramide as prokinetic agents. British Journal of
Anasthesia 2001;86:869-71.
9. Wyllie. Motility disorders and hirschsprung disease. In:
Behrman RE, Kliegman RM, Jenson HB, editors. Nelson
textbook of pediatrics. 16 th ed. Philadelphia: Saunders, 2000;
p. 1138-9.
10. Coulie B, Tack J, Peeters T, Janssens J. Involvement of two
different pathways in the motor effects of erythromycin on
the gastric antrum in humans. Gut 1998;43:395-400.
11. Jadcheria SR, Berseth CL. Effect of erythromycin on
gastroduodenal contractile activity in developing neonates.
J Pediatr Gastrol Nutr 2002;34:16-22.
12. Miller P, Roy A, St-Pierre S, Dagenals M, Lapointe R, Poitras
P. Motilin receptors in the human antrum. Am J Physol 2000;
278:618-23.
13. Peeters T, Matthijs G, Depoortene I, Cachet T, Hoogmartens
J, Vantrappen G. Erythromycin is a motilin receptor agonist.
Am J Physiol 1989;257:G470-4.
14. Amir I, Rohsiswatmo R, Kaban RK. Penatalaksanaan bayi berat
badan lahir rendah. In: Rusdidjas, Dasa Tjipta G, editors.
Makalah lengkap kongres nasional VIII perinasia & simposium
internasional. Medan: BIKA FK USU; 2003. p. 500-16.
15. Patole SK, Rao S, Doherty D. Erythromycin as a prokinetic
agent in preterm neonates-a systematic review. Arch Dis
Child Fetal Neonatal 2005;90:F301-6.
16. Slater-Myer LP, Saslow JG, Stahl GE. Development of the
gastrointestinal tract. In: Spitzer AR, editor. Intensive care
of the fetus and neonate. St Louis: Mosby; 1996. p. 843-56.
Published
2007-10-31
How to Cite
1.
Moesri A, Lubis B, Asrul A, Sinuhaji A, Tjipta G. Oral erythromycin for treatment of gastrointestinal dysmotility in premature infants. PI [Internet]. 31Oct.2007 [cited 24Apr.2024];47(5):234-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/421
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Received 2016-09-01
Accepted 2016-09-01
Published 2007-10-31
Accepted 2016-09-01
Published 2007-10-31
