Clinical and laboratory profiles of hepatitis C in hemophiliac children
Background Hepatitis C virus (HCV) infection is common inÂ hemophiliac receiving multiple coagulation factor transfusionsÂ before the introduction of donor screening and viral inactivationÂ techniques. Information on the clinical profiles of HCV infectionÂ in children is still limited.
Objective To describe clinical and laboratory profiles of HCVÂ infection in hemophiliac children.Â
Methods Patients registered at the Hemophilia Society ofÂ Department of Child Health, Cipto Mangunkusumo Hospital,Â who had positive anti-HCV were enrolled. None of them receivedÂ antiviral treatment. All subjects infected by HCV before the ageÂ of 18 years and at least had positive anti-HCV test result for 6Â months underwent clinical examination, alanine aminotransferaseÂ (ALT), platelets, and HCV RNA tests.
Results Thirty nine subjects were available for review, with theÂ median age of 15 years, and the mean age of the first time gettingÂ transfusion was 15 months. Twenty two (56%) of 39 subjectsÂ showed clinical manifestations. Liver and spleen enlargement wereÂ not found in any of the subjects. Ten (26%) subjects showedÂ elevated ALT. Platelet count was within normal limit in allÂ subjects. Twenty four (61%) patients had chronic hepatitis,Â whereas the remaining 15 (39%) subjects spontaneously clearedÂ from HCV.
Conclusions Pediatric HCV infection showed mild clinicalÂ manifestations. Sixty one percent subjects developed chronicÂ hepatitis. The abnormality of laboratory finding may be associatedÂ with the future chronic liver disease.
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